C. Cramer and L. Chase. Hope Col., MI.
C256
1017.9 Identification of putative trafficking motifs in
System x
c
-
.
S. Lang, A. Georges and L. Chase. Hope Col., MI.
C257
1017.10 Cell surface expression of xCT is regulated by
the Akt signaling pathway.
L. Chase, D. Smith and N. Schiller.
Hope Col., MI.
C258
1017.11 Vitamin E and nonalcoholic fatty liver disease.
V. Thakur, L. Ulatowski, R. Parker, R. Zhang, X. Liu and
D. Manor. Case Western Reserve Univ., Cornell Univ. and
Cleveland Clin. Fndn.
C259
1017.12 Global deletion of stearoyl-CoA desaturase-2
enhances glucose tolerance.
L. O’Neill and J. Ntambi. Univ. of
Wisconsin-Madison.
C260
1017.13 Characterization of the role of long chain acyl-
CoA synthetase 6 in skeletal muscle energy metabolism.
S.Y.
Bu. Kyungil Univ., South Korea.
C261
1017.14 When fed a high-fat diet,GPAT4
-/-
mice have
an increased metabolic rate and impaired growth and weight
gain.
D. Cooper and R.A. Coleman. Univ. of North Carolina at
Chapel Hill.
BIOCHEMISTRY TUESDAY
339
T
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1018. LIPID SECOND MESSENGERS
Poster
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C262
1018.1 cAMP-stimulated expression of DGK
q requires
steroidogenic factor-1 and sterol regulatory element binding
protein.
K. Cai and M. Sewer. Skaggs Sch. of Pharm. and
Pharmaceut. Sci., UCSD.
C263
1018.2 The basis of the substrate specificity of
the epsilon isoform of human diacylglycerol kinase is not a
consequence of competing hydrolysis of ATP.
R.M. Epand,
A. Prodeus, B. Berno and M.K. Topham. McMaster Univ.,
Canada and Univ. of Utah.
C264
1018.3 Phospholipase C
b1 is linked to RNA
interference of specific genes through translin-associated
factor X.
S. Scarlata, F. Philip and Y. Guo. Stony Brook Univ.
1019. LIPID SIGNALING
Poster
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. 7:30
am
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C265
1019.1 Characterization of tocopherol kinase activity
in primary human coronary artery smooth muscle cells.
J-M.
Zingg, M. Meydani and A. Azzi. Tufts Univ.
C266
1019.2 Expression and characterization of
recombinant neutral sphingomyelinase 2 in Escherichia coli:
evidence of sensitivity to redox state.
P.P. Dotson II and M.
Nikolova-Karakashian. Univ. of Kentucky.
C267
1019.3 Searching the extracellular domain of CD36 for
fatty acid binding by surface plasmon resonance.
A. Jay, A.
Chen and J.A. Hamilton. Boston Univ.
C268
1019.4 The role of endosomal phosphoinositides in
phagocytosis, phagosome maturation and the endosomal
system in macrophages.
G.H.E. Kim, M. Dayam and R.
Botelho. Ryerson Univ., Canada.
C269
1019.5 Vac14 multimerization is required for Fab1
complex assembly and function.
S.C.Y. Ho, T. Alghamdi and
R.J. Botelho. Ryerson Univ., Canada.
C270
1019.6 Membrane ultrastructure modulates immune
cell signaling.
A. Pralle, H. Huang and M. Simsek. Univ. at
Buffalo.
1020. LIPID STORAGE
Poster
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. 7:30
am
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Presentation time: 12:25
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pm
C271
1020.1 Cholesteryl ester transfer protein deficiency in
adipocytes disrupts triglyceride metabolism in multiple ways.
D.J. Greene and R.E. Morton. Lerner Res. Inst., Cleveland
Clin.
C272
1020.2 Both full-length and exon 9-deleted human
cholesteryl ester transfer protein isoforms are involved in
cellular lipid homeostasis.
L. Izem and R.E. Morton. Lerner
Res. Inst., Cleveland Clin.
C273
1020.3 Characterization of the proteome of cytoplamic
lipid droplets in enterocytes in response to dietary fat.
T.
D’Aquila, D. Sirohi, R.J. Kuhn and K.K. Buhman. Purdue
Univ.
C274
1020.4 Characterization of a perilipin 5 splice variant.
T.C. Hubbell, D.M. DuBreuil and J.T. Tansey. Otterbein Univ.,
OH.
1021. PROTEIN-LIPID INTERACTIONS
Poster
t
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. 7:30
am
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oston
C
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Presentation time: 12:25
pm
-1:55
pm
C275
1021.1 Acrolein, a component of tobacco smoke and
age-related oxidative stress disrupts structure and function
of apolipoprotein E.
T.N. Tran, Y.Y. Lee, K. Uchida and V.
Narayanaswami. California State Univ., Long Beach, and
Grad. Sch. of Agr. Sci., Nagoya Univ., Japan.
C276
1021.2 Fatty acids and their thioester derivatives
as potential endogenous ligands of LXR
a. G.V. Hines, A.
Kaliappan, S.D. Rider, Jr. and H.A. Hostetler. Boonshoft Sch.
of Med., Wright State Univ.
C277
1021.3 A characterization of the modular nature
of histone-derived antimicrobial peptides.
M.E. Bustillo,
M.A. LaBouyer, A.L. Fischer, D.C. Webb and D.E. Elmore.
Wellesley Col.
C278
1021.4 A modular approach to the histone H2A family
of antimicrobial peptides.
A.L. Fischer, M. Bustillo and D.E.
Elmore. Wellesley Col.
C279
1021.5 Engineering a specific phosphatidylcholine
binding site motif into a phosphatidylinositol-specific
phospholipase C.
R. Goldstein, J. Cheng, B. Stec, A.
Gershenson and M.F. Roberts. Boston Col., Sanford-
Burnham Med. Res. Inst., La Jolla and Univ. of Massachusetts
Amherst.
C280
1021.6 Role of arginine and lysine in the antimicrobial
mechanism of histone-derived peptides.
K. Cutrona and D.
Elmore. Wellesley Col.
C281
1021.7 Biochemical analysis unveils the mechanism
of the interaction between Hsp70s and lipids.
C. McCallister
and N. Nikolaidis. California State Univ., Fullerton.
C282
1021.8 Spatial and temporal regulation of the Nedd4
family ubiquitin ligases through phospholipid binding.
J. Scott
and R.V. Stahelin. Univ. of Notre Dame and Indiana Univ. Sch.
of Med. South Bend.
C283
1021.9 Lipid binding properties of Ebola virus matrix
protein VP40.
S. Yong, J.L. Scott and R.V. Stahelin. Univ. of
Notre Dame and Indiana Univ. Sch. of Med. South Bend.
C284
1021.10 The interaction of Hsp70s and lipids is
conserved from bacteria to humans.
M.C. Siracusa and N.
Nikolaidis. California State Univ., Fullerton.
C285
1021.11 Expression and purification of a MORN fusion
protein from Pseudomonas aeruginosa.
C.C. Anderson, L.C.
MacDonald, J.B. Nice, B.W. Berger and C.N. Streu. St.
Mary’s Col. of Maryland and Lehigh Univ.
TUESDAY BIOCHEMISTRY
340
1022. STRESS AND LIPID METABOLISM
Poster
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. 7:30
am
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oston
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Presentation time: 12:25
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pm
C286
1022.1 Modulating lipid fate controls lipotoxicity in
palmitate-treated hepatic cells.
A. Leamy, M. Shiota and J.
Young. Vanderbilt Univ.
C287
1022.2 Protective effects of coenzyme Q10 on
dystrophic muscle cells.
E. Minatel, D.S. Mizobuti, A.B.
Macedo and L.H.R. Moraes. Univ. of Campinas, Brazil.
1023. STRUCTURAL BIOLOGY AND MECHANISMS OF
MEMBRANE LIPID ASSEMBLY
Poster
t
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. 7:30
am
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Presentation time: 12:25
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pm
C288
1023.1 Probing the structure and function of ApoA-I
C-terminal domain during HDL formation.
X. Mei and D.
Atkinson. Boston Univ. Sch. of Med.
C289
1023.2 Mechanisms of non-random sphingolipid
organization in the plasma membranes of fibroblast cells.
M.L.
Kraft, H.A. Klitzing, J.F. Frisz, K. Kou, P.K. Weber and J.
Zimmerberg. Sch. of Chem. Sci., Univ. of Illinois at Urbana-
Champaign, Lawrence Livermore Natl. Lab. and NICHD, NIH.
1024. LIPID DOMAINS AND LIPID RAFTS
Poster
t
ue
. 7:30
am
—B
oston
C
onvention
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a-B
Presentation time: 12:25
pm
-1:55
pm
C290
1024.1 The iron transport inhibitor ferristatin II induces
degradation of transferrin receptor-1.
S.L. Byrne, P.D. Buckett,
J. Sanford, J. Chen, C. Enns and M. Wessling-Resnick.
Harvard Sch. of Publ. Hlth. and Oregon Hlth. & Sci. Univ.
C291
1024.2 Differential oligomeric nature of mEos2 and
mEos3.2 fluorescent proteins is consequential to diffusion and
confinement of membrane probes.
E. Edwald and S.L. Veatch.
Univ. of Michigan.
1025. MEMBRANE PROTEIN SYNTHESIS, INSERTION
AND ASSEMBLY
Poster
t
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. 7:30
am
—B
oston
C
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Presentation time: 12:25
pm
-1:55
pm
C292
1025.1 Targeting of a mating machinery ATPase to
the cell membrane.
M.P. Broulidakis, S.J. Laurer and M.B.
Berkmen. Suffolk Univ., MA.
C293
1025.2 Structural insights into the role of BamA in the
biogenesis of beta-barrel membrane proteins in Gram-negative
bacteria.
N. Noinaj, A. Kuszak, J.C. Gumbart, P. Lukacik, H.
Chang, N. Easley, T. Lithgow and S.K. Buchanan. NIDDK,
NIH, Georgia Tech, Diamond Light Source Ltd, Oxford, FDA,
Rockville and Monarch Univ., Australia.
1026. PROTEIN-LIPID INTERACTIONS AS
DETERMINANTS OF FUNCTION
Poster
t
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. 7:30
am
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oston
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Presentation time: 12:25
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pm
C294
1026.1 Regulation of the ATP hydrolysis and transport
cycles of the P-glycoprotein multidrug transporter by sterols
and phospholipids.
F.J. Sharom, A.T. Clay and P. Lu. Univ. of
Guelph, Canada.
C295
1026.2 Surprising phospholipid specificity of two blood
clotting proteins: factor VII and protein C.
N. Tavoosi and J.H.
Morrissey. Univ. of Illinois at Urbana-Champaign.
C296
1026.3 The role of cardiolipin in defining the mammalian
ANT interactome.
Y-W. Lu, M.G. Baile, T-C. Huang, A. Pandey
and S.M. Claypool. Johns Hopkins Univ. Sch. of Med.
1027. CELL CYCLE
Poster
t
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. 7:30
am
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oston
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Presentation time: 12:25
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pm
C297
1027.1 Cell cycle regulation mechanism in pathogenic
yeast, Cryptococcus neoformans: structure-function
relationship of G1 and G1/S cyclins homologue CnCln1.
S.
Kawamoto, E.V. Virtudazo, A. Suganami and Y. Tamura.
Chiba Univ. Med. Mycol. Res. Ctr. and Grad. Sch. of Med.,
Japan.
C298
1027.2 Video time lapse imaging of mitotic catastrophe
events in response to thiopurines.
S. Patel and D. Pittman.
Univ. of South Carolina and South Carolina Col. of Pharm.
C299
1027.3 Identification and characterization of mitotic
defect-related proteins (MDr1 and MDr2) necessary for bipolar
spindle assembly.
K. Cheung and J. Torres. UCLA.
C300
1027.4 The disruption of the mitotic cell cycle exit by
inositolless death in S. cerevisiae.
B.A. Hanson, P.O. O’Connor,
J. Frandina, J. Pittari, J. Munezero and V. Croglio. Canisius
Col., NY.
C301
1027.5 Paradoxical effects of metformin on the cell
cycle in L6 myoblasts.
R. Parakhia and R.S. Ochs. St. John’s
Univ., NY.
C302
1027.6 Adiponectin receptor (ADIPOR1) signaling
ameliorates obesity-dependent cell cycle entry in MCF7 cells.
M. Connor and C. Theriau. York Univ., Canada.
C303
1027.7 The ubiquitin conjugating enzyme UbcH10
competes with UbcH3 for binding to the SCF complex, a
ubiquitin ligase involved in cell cycle progression.
A.Y. Le
Feuvre, D. Afful, F. Shang and A. Taylor. USDA at Tufts Univ.
BIOCHEMISTRY TUESDAY
341
T
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C304
1027.8 The SUMO ligase PIAS1 promotes the
progression and survival of solid tumors of different
histopathological origins.
J.D. Constanzo, A. Rabellino, G.
Konstantinidou, K. Schuster and P. Scaglioni. Univ. of Texas
Southwestern Med. Ctr.
1028. CELL CYCLE AND GROWTH CONTROL
Poster
t
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. 7:30
am
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oston
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Presentation time: 12:25
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-1:55
pm
C305
1028.1 MED28 regulates cell growth through HMG
box-containing protein 1 in human breast cancer cells.
N-T.
Hsieh, C-Y. Huang, Y-H. Chou, W.C. Ung and M-F. Lee. China
Med. Univ. and Chang Jung Christian Univ., Taiwan.
C306
1028.2 Cranberry proanthocyanidins affect human
prostate cancer cell growth via cell cycle arrest by modulating
expression of cell cycle regulators.
R. Hurta, J. Kim, B.
McKeown, K. Patel and C. Neto. Univ. of Prince Edward Isl.,
Canada and Univ. of Massachusetts Dartmouth.
C307
1028.3 Artemisia princeps var. orientalis induces
cell cycle arrest accompanied by upregulation of p21,
CIP1
and
caspase-dependent apoptosis in human breast carcinoma
cells.
E-J. Choi and G-H. Kim. Duksung Women’s Univ., South
Korea.
C308
1028.4 Functional analysis of the interaction between
Kaposi sarcoma-associated herpes virus anti-apoptotic Bcl-
2 homolog and the human host pro-apoptotic protein, Bik.
B.
Caruso, S. Walker and J. Roecklein-Canfield. Simmons Col.
C309
1028.5 Muscle enriched A-type lamin interacting
protein a novel regulator cardiac growth and function.
M-E.
Cattin, E. Mak-Washburn and P.G. Burgon. Univ. of Ottawa
Heart Inst.
C310
1028.6 Effects of sulforaphane on three tumor cell
lines and one normal cell line.
F. Jin, T. Terwilliger, J. Bosch
and R.W. O’Donnell. SUNY Geneseo.
C311
1028.7 Using carboxyfluorescein succinimidyl ester
to measure the effects of sulforaphane on cell division in a
human leukemia cell line.
K. Lehner, O. Feliciano and R.W.
O’Donnell. SUNY Geneseo.
1029. CHECKPOINT MECHANISMS
Poster
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. 7:30
am
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C312
1029.1 Nuclear localized BMP2 promotes cell cycle
progression.
B.A. Nichols, W.A. Goar, B.T. McCune and L.C.
Bridgewater. Brigham Young Univ.
1030. CYCLINS AND CYCLIN-DEPENDENT KINASES
Poster
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. 7:30
am
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Presentation time: 12:25
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pm
C313
1030.1 The role of cyclin-dependent kinase 5 in insulin
exocytosis.
A. Trye and A. Aguanno. Marymount Manhattan
Col.
C314
1030.2 Pentoxifylline initiates GSK-3
b-induced
proteasomal degradation of cyclin D1 and arrests renal cancer
cells in the G1 phase.
W. Cai, N.J. Mastrandrea, K.Y. Tham,
T.J. Monks and S.S. Lau. Univ. of Arizona Col. of Pharm.
C315
1030.3 Cyclin dependent kinase 5’s role in the
development of both insulin-positive and neuronal phenotypes.
D.E. Khost and A. Aguanno. Marymount Manhattan Col.
1031. MECHANISMS OF SIGNAL TRANSDUCTION II
Poster
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. 7:30
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-1:55
pm
Session I scheduled on Monday.
C316
1031.1 YAP mediates crosstalk between the Hippo
and PI(3)K–TOR pathways by suppressing PTEN via miR-29.
K.A. Tumaneng. UCSD.
C317
1031.2 A-kinase anchoring protein-Lbc coordinates
protein kinase A phosphorylation and inhibition of Src homology
2 domain-containing phosphatase 2.
B.T. Burmeister, D.M.
Taglieri, L. Wang and G.K. Carnegie. Univ. of Illinois at
Chicago.
C318
1031.3 Specific mutations on the receptor-binding
interface of non-visual arrestins differently affect recruitment
by the NPY receptor family.
L.E. Gimenez, S. Babilon, A.G.
Beck-Sickinger and V.V. Gurevich. Vanderbilt Univ. Med. Ctr.
and Leipzig Univ.
C319
1031.4 Analysis of MILLIPLEX
®
MAP NF
kB signaling
using Luminex
®
xMAP
®
technology.
J. Hwang, T. Warmke and
R. Wiese. EMD Millipore, St. Charles, MO.
C320
1031.5 Inhibition of ERK5 protects pulmonary fibrosis
via downregulation of TGF-
b1-Smad signaling. S. Kim, S. Park,
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