N.G. Zanluqui, V.L. Tatakihara, A.P.L. de Oliveira, J.P.S.
Peron, N.O.S. Camara, K.L. Fritsche and P. Pinge-Filho.
State Univ. of Londrina, Brazil, Univ. of São Paulo and Univ. of
Missouri-Columbia.
D450
II 866.8 Select amino acids induced expression
of human beta-defensin in Caco-2 cells.
K. Osei-Boadi, E.
Gordon and T. Melgarejo. Kanasas State Univ.
D451
I 866.9 Homocysteine levels are associated
with HIV disease progression in HIV
+
adults in Miami.
S.S.
Martinez, A. Campa, Y. Li, J.H. Boyer, S. Williams, S. Barr,
G. Nagi, P. Greer, D. Gracia and M.K. Baum. R. Stempel Col.
of Publ. Hlth. and Soc. Work, Florida Intl. Univ. and Borinquen
Hlth. Care Ctr., Miami.
D452
II 866.10 A pilot study of TLR4 polymorphism
in relation to intestinal dysbiosis and risk of necrotizing
enterocolitis in preterm infants.
D.H. Taft, L. Kottyan, A.J.
Lagomarcino, K.R. Schibler, Z. Yu, D. Gevers, D.V. Ward,
C. Huttenhower, D.S. Newburg and A.L. Morrow. Univ. of
Cincinnati, Cincinnati Children’s Hosp. and Med. Ctr., Boston
Col., Broad Inst., Cambridge, MA and Havard Sch. of Publ.
Hlth.
867. ANIMAL RESEARCH MODELS IN INTESTINAL
PHYSIOLOGY AND DIGESTIVE FUNCTION
Poster
(Sponsored by: Experimental Animal Nutrition RIS)
m
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. 7:30
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enter
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Presentation time: 12:45
pm
-1:45
pm
(I); 1:45
pm
-2:45
pm
(II)
D453
I 867.1 Dietary nucleotides and yeast extract
affect the composition and metabolic activities of the swine gut
microbiota in a new in vitro fermentation model.
E-H. Doo, C.
Chassard and C. Lacroix. ETH Zurich.
D454
II 867.2 Impact of systemic immune system
stimulation on intestinal integrity and function in pigs.
A.
Rakhshandeh, T.E. Weber, J.C.M. Dekkers, C.K. Tuggle, B.J.
Kerr and N.K. Gabler. Iowa State Univ. and USDA, Ames.
D455
I 867.3 Absorption of marine versus non-marine
sources of EPA and DHA.
J.S. Ketz, M.C. Rodavich and K.M.
Barnes. West Virginia Univ.
D456
II 867.4 Glucagon-like peptide-2 therapy
improves outcomes of intestinal adaptation and decreases
relative apoptosis in a distal intestinal resection neonatal
piglet model of short bowel syndrome.
M. Suri, J.M. Turner,
P.N. Nation, P. Wizzard, P.L. Brubaker, D.L. Sigalet and P.W.
Wales. Univ. of Toronto, Stollery Children’s Hosp., Edmonton,
Univ. of Alberta, Alberta Children’s Hosp. and SickKids Hosp.,
Toronto.
D457
I 867.5 High renal calcium (Ca) excretion does
not reduce femur bone density in mice fed adequate or low
dietary Ca.
P.C. Reyes Fernandez and J.C. Fleet. Purdue
Univ.
D458
II 867.6 Prebiotic short chain
fructooligosaccharides increase butyrate but not short chain
fatty acid receptor or transporter mRNA in an intestinal
failure piglet model.
J.L. Barnes, G.C. Fahey, Jr. and K.A.
Tappenden. Univ. of Illinois at Urbana-Champaign.
D459
I 867.7 Supplementation of commercial pig
feed with palm oil during pregnancy downregulates genes
related to development and permeability in the offspring small
intestine.
S.M. Astbury, R.C. Bell, A. Mostyn, D. Sharkey and
M.E. Symonds. Univ. of Nottingham and Univ. of Alberta.
D460
II 867.8 The effects of Actigen™ and dietary
threonine on nursery pig gut morphology.
L. Good, R.S. Samuel,
D.E. Graugnard, A.J. Pescatore, J.S. Jolliff, D.C. Mahan and
K.M. Brennan. Univ. of Kentucky, Alltech, Nicholasville, KY and
The Ohio State Univ.
D461
I 867.9 Increasing amylose content of starch
stimulates fermentation and is bifidogenic in weaned pigs.
J.M.
Fouhse, M. Gänzle, P. Regmi, T. van Kempen and R. Zijlstra.
Univ. of Alberta and North Carolina State Univ.
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NUTRITION MONDAY
277
M
O
N
Pathology
A400
869.4
Endothelial apoptosis and glycocalyx
morphology in plaque and non-plaque areas of the mouse
atherosclerotic brachiocephalic artery.
L.M. Cancel, E.E.
Ebong and J.M. Tarbell. City Col. of New York and Albert
Einstein Col. of Med.
A401
869.5
Interleukin-17A plays an important role in
endothelial cell activation and atherogenesis in ApoE-/- mice.
J. Mai, H. Wang and X-F. Yang. Temple Univ. Sch. of Med.
A402
869.6
IL-19 attenuates progression of
atherosclerosis, modifies macrophage phenotype and lipid
uptake in macrophage and VSMC.
K. Gabunia, S. Ellison, S.
Kelemen, J. Richards and M. Autieri. Temple Univ. Sch. of
Med.
A403
869.7
Attenuation of experimental atherosclerosis
by interleukin-19.
S. Ellison, K. Gabunia, J. Richards, S.E.
Kelemen, R.N. England, R. Scalia, A.W. Orr, L.M. Berglund,
M.F. Gomez and M.V. Autieri. Temple Univ. Sch. of Med, LSU
Hlth. Sci. Ctr., Shreveport and Lund Univ., Sweden.
870. VASCULAR BIOLOGY AND ENDOTHELIAL
DYSFUNCTION IN DISEASE
Poster
m
on
. 7:30
am
—B
oston
C
onvention
& e
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C
enter
,
e
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h
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a-B
Presentation time: 11:45
am
-1:45
pm
A404
870.1
Role of miR-19a in the development of
abdominal aortic aneurysm.
Y. Zhang, H-J. Park and J.B.
Galper. Tufts Med. Ctr.
A405
870.2
Inhibition of VSMC activation and vascular
restenosis by interleukin-19.
S. Ellison, J. Richards, A.
Miecyjak, K. Gabunia, S. Kelemen and M. Autieri. Temple
Univ. Sch. of Med.
A406
870.3
The hyaluronan receptor RHAMM promotes
constrictive artery wall remodeling.
X. Ma, J.D. Pearce, J. Li,
D.B. Wilson, W.P. English, M.S. Edwards and R.L. Geary.
Wake Forest Univ.
A407
870.4
Smooth muscle nitric oxide responsiveness
predicts clinical maturation of hemodialysis fistulae.
X. Hou,
L.M. Dember, C. Wason, R.A. Cohen, X. Tong and H. Study
Group. Boston Univ. and Univ. of Pennsylvania Perelman Sch.
of Med.
A408
870.5
Serum amyloid A and Toll-like receptor 2
activation promote de-differentiation of vascular smooth
muscle cells.
L.G. Pessolano, Jr., S.E. Seidl, C.B. Rich and
B.M. Schreiber. Boston Univ. Sch. of Med.
A409
870.6
Association between metabolic syndrome
and serum vitamin D concentration in patients undergoing
coronary artery bypass graft.
M.M. Corsi Romanelli, E. Dozio,
G. Dogliotti, A. Barassi, E. Vianello, A.E. Malavazos and G.
Melzi d’Eril. State Univ. of Milano and IRCCS Polyclin. San
Donato, Italy.
A410
870.7
High glucose induced monocyte-to-
macrophage differentiation: role of AMPk.
S.B. Vasamsetti, P.
Rao and S. Kotamraju. CSIR-Indian Inst. of Chem. Technol.,
Hyderabad.
A411
870.8
Cerebrovascular endothelial cell activation in
paediatric diabetic ketoacidosis.
T. Omatsu, G. Cepinskas
and D.D. Fraser. Lawson Hlth. Res. Inst. and Children’s Hlth.
Res. Inst., London, Canada.
868. SEPSIS AND INFLAMMATION
Poster
m
on
. 7:30
am
—B
oston
C
onvention
& e
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C
enter
,
e
xhiBit
h
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a-B
Presentation time: 11:45
am
-1:45
pm
A390
868.1
Myeloid expression of co-inhibitory receptor
ligand, B7-H1, as a novel biomarker/mediator of septic
progression/morbidity.
X. Huang, Y. Chen, C-S. Chung, S.F.
Monaghan and A. Ayala. Brown Univ. Sch. of Med., Rhode
Island Hosp.
A391
868.2
Pathophysiologic and metabolomic analyses in
a model for closed abdomen septic swine treated with negative
pressure therapy.
K.C. Norbury. Kinetic Concepts Inc., San
Antonio.
A392
868.3
Inflammatory and antioxidant response in
obese septic shock patients.
V.J. Victorino, H.V. Barbeiro, D.F.
Barbeiro, F.P. Silva and H.P. Souza. São Paulo Univ. Sch. of
Med.
A393
868.4
Value of fever versus hypothermia in severe
sepsis.
E. Liu, J.J. Corrigan, K. Lewis, H. Al-Saffar, C.M.
Krall, A. Singh, V.A. Kulchitsky, C.T. Simons, S.R. Petersen,
F.M. Musteata, C.S. Bakshi, A.A. Romanovsky, T.J. Sellati
and A.A. Steiner. Albany Col. of Pharm. and Hlth. Sci., Univ.
of Pennsylvania, Albany Med. Col., Legacy Holladay Park Med.
Ctr., Portland, St. Joseph’s Hosp., Phoenix, New York Med Col.
and Univ. of São Paulo.
A394
868.5
Continuous exhaled breath carbon isotope
analysis for early detection of sepsis.
D.E. Butz, S.L. Morello,
J. Sand, J.P. Boriosi, G.N. Holland and M.E. Cook. Sch. of
Vet. Med. and Sch. of Med. and Publ. Hlth., Univ. of Wisconsin-
Madison and Isomark LLC, Madison.
A395
868.6
Selectins and integrins in ischemia-reperfusion
and sepsis induced murine acute kidney injury.
J.M. Herter, H.
Block, J. Rossiant, A. Stadtmann and A. Zarbock. Univ. of
Muenster and Max Planck Inst. for Molec. Biomed., Muenster.
A396
868.7
Severe sepsis cytomix elicits inflammation
in cerebrovascular endothelial cells and polymorphonuclear
leukocytes in vitro.
C. Blom, B. Deller, D.D. Fraser, C. Martin,
B. Young and G. Cepinskas. Lawson Hlth. Res. Inst., London,
Canada.
869. VASCULAR BIOLOGY OF ATHEROSCLEROSIS
Poster
m
on
. 7:30
am
—B
oston
C
onvention
& e
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C
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,
e
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a-B
Presentation time: 11:45
am
-1:45
pm
A397
869.1
A combinational therapy on atherosclerosis.
J.
Han, Y. Chen and Y. Duan. Nankai Univ., China.
A398
869.2
Role of Nox4 in modulating atherosclerosis in
diabetes.
A.R. Khandelwal, L. Chen, Z. Qin, X. Hou, J. Xiao, J.
Sadoshima and X. Tong. Boston Univ. Med. Ctr. and UMDNJ-
New Jersey Med. Sch.
A399
869.3
EP4 antagonist suppresses MMP-9 expression
in aortas derived from apoE-null mice.
K.M.F. Khan and D.J.
Falcone. Joan and Sanford I. Weill Med. Col. of Cornell Univ.
MONDAY PATHOLOGY
278
871. COAGULATION, ANGIOGENESIS AND
INFLAMMATION
Poster
m
on
. 7:30
am
—B
oston
C
onvention
& e
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C
enter
,
e
xhiBit
h
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a-B
Presentation time: 11:45
am
-1:45
pm
A412
871.1
Compositional differences in commercial
available prothrombin complex concentrates and their activation
by tissue factor.
D. Kahn, D. Hoppensteadt, J. Harenberg, J.
Fareed and A. Only. Loyola Univ. Med. Ctr., Maywood and
Ruprecht Karls Univ. Heidelberg.
A413
871.2
Relative neutralization of unfractionated
heparin and various enoxaparins by platelet factor 4 in platelet
rich plasma: therapeutic implications.
D. Syed, O. Iqbal, D.
Hoppensteadt, W. Jeske and J. Fareed. Loyola Univ. Med.
Ctr.
A414
871.3
Gene sequencing aids in differentiation of
von Willebrand disease type 2B from platelet-type vWD.
D.S.
Desai, E. Lyon, G. Rodgers, M. Jama, S. Wallentine and K.
Smock. ARUP Labs., Univ. of Utah Hlth. Sci. Ctr. and Central
Utah Clin., Provo.
A415
871.4
Redox regulation of cysteine-674 of SERCA 2
is critical for growth factor- and ischemia-induced angiogenesis.
M.D. Thompson, Y. Mei, X. Hou, M. Silver, V.M. Bolotina, R.A.
Cohen and X. Tong. Boston Univ. Sch. of Med.
A416
871.5
Oxidation of SERCA2 at cysteine 674
increases ER stress during hind limb ischemia in mice.
Y. Mei,
M.D. Thompson, M. Silver and R.A. Cohen. Boston Univ.
872. LIVER PATHOBIOLOGY
Poster
m
on
. 7:30
am
—B
oston
C
onvention
& e
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C
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,
e
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a-B
Presentation time: 11:45
am
-1:45
pm
A417
872.1
Acceleration of liver regeneration by betaine
supplementation via enhancement of sulfur-containing amino
acid metabolism.
C.W. Ahn, D.S. Jun and Y.C. Kim. Seoul
Natl. Univ. Col. of Pharm.
A418
872.2
Wnt5a inhibits
b-catenin signaling and
proliferation in hepatocyte cultures: implications in liver
regeneration.
J.K. Monga, S. Ravindramurthy, A. Cusimano,
K.N. Nejak-Bowen and S.P. Monga. Univ. of Pittsburgh.
A419
872.3
Regulation of liver growth by Glypican 3, CD81,
Hedgehog, and Hhex.
V. Bhave, W. Mars, S. Donthamsetty,
J. Luo, W. Bowen and G. Michalopoulos. Univ. of Pittsburgh
Sch. of Med.
A420
872.4
Adaptation to chronic alcohol intake
alters STAT3 genome-wide binding dynamics during liver
regeneration.
B. Patra, L. Kuttippurathu, R. Vadigepalli and
J.B. Hoek. Thomas Jefferson Univ.
A421
872.5
Mitochondrial unfolded protein response
participates in hepatic dysfunction in sepsis.
L-J. Huang, J-J.
Ho and R-C. Yang. Kaohsiung Med. Univ. and Hosp., Taiwan.
A422
872.6
w-3 Fatty acid effects on obese leptin knockout
mice.
A. Ali, J. Nachnani, D. Bulchandani, L. Alba, A.
Mansour, H. Hamdan, T. Quinn, A. Molteni and B. Herndon.
Univ. of Missouri-Kansas City Sch. of Med. and Sumner Med.
Gp., Gallatin, TN.
A423
872.7
Targeting mTOR signaling for the prevention of
progenitor-derived hepatocellular carcinoma.
J.A. Sanders, K.
Brilliant, H. Francois and D. Mills. Rhode Island Hosp. and
Alpert Med. Sch., Brown Univ.
A424
872.8
b-Catenin and HCC phenotype in mice and
men.
J.M. Lee, P. Newell, S. Friedman and S.P. Monga. Univ.
of Pittsburgh and Mount Sinai Sch. of Med.
A425
872.9
A one, two finish of
b-catenin: targeting its
activity and synthesis in hepatocellular carcinoma by novel
small molecules and antisense peptide-nucleic acids.
E.R.
Delgado, R. Bahal, D. Ly, G. Mustata and S.P.S. Monga. Univ.
of Pittsburgh, Yale Univ., Carnegie Mellon Univ. and Univ. of
Southern Indiana.
A426
872.10 Epigenetic regulation of miR-122 by PPAR
g
and hepatitis B virus X protein in hepatocellular carcinoma
cells.
K-s. Song, C. Han and T. Wu. Tulane Univ. Sch. of Med.
A427
872.11 Glypican 3 increases IRS4 phosphorylation
and stimulates hepatocellular carcinoma cell proliferation.
E.
Ganapathy, R. Khachatoorian and S.W. French. UCLA.
A428
872.12 A novel in vitro three-dimensional bioprinted
liver tissue system for drug development.
J.B. Robbins, V.
Gorgen, P. Min, B.R. Shepherd and S.C. Presnell. Organovo
Inc., San Diego.
873. NEUROPATHOLOGY
Poster
m
on
. 7:30
am
—B
oston
C
onvention
& e
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C
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,
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a-B
Presentation time: 11:45
am
-1:45
pm
A429
873.1
A rare presentation of intravascular lymphoma
in an HIV patient.
S. Solomon, R. Dalal, S. Dunlap and M.
Kurukumbi. Howard Univ. Hosp.
A430
873.2
Expression of orphan G protein-coupled
receptors in glioblastomas.
G.R. Kolar and G.L.C. Yosten.
Washington Univ. in St. Louis and Saint Louis Univ.
A431
873.3
M-type K
+
channel openers: in vivo
neuroprotective role during cerebrovascular stroke.
S.M.
Bierbower, F. Choveau and M.S. Shapiro. Univ. of Texas Hlth.
Sci. Ctr. at San Antonio.
A432
873.4
IL-6 mediates impaired motor coordination but
not cognition in a murine model of mild traumatic brain injury.
S.H. Yang, M. Gangidine, T. Pritts and A. Lentsch. Univ. of
Cincinnati.
A433
873.5
Effect of fetal cells of the nervous tissue during
postresuscitational encephalopathy in rats of different sex and
ages.
Z. Aitbayeva. Med. Univ. Astana, Kazakhstan.
A434
873.6
Evaluation of the VPT-60 to measure peripheral
nerve sensitivity.
J. Gibson, M. Blackburn, P. Breen and N.S.
Latman. West Texas A&M Univ., Natl. Univ. of Ireland Galway
and Univ. of Western Sydney.
A435
873.7
From animal models to clinical practicality:
lessons learned from current translational progress in diabetic
peripheral neuropathy research.
C. Li and N. Barnard.
Physicians Cmte. for Responsible Med., Washington, DC.
A436
873.8
Hyperactivity and cognitive flexibility in animals
with temporal lobe epilepsy.
F.O. Ramos, R.M. Cysneiros
and F.A. Scorza. Fed. Univ. of São Paulo and Mackenzie
Presbiterian Univ., Brazil.
PATHOLOGY MONDAY
279
M
O
N
A437
873.9
CAP37: a marker of neuroinflammation.
A.J.
Brock, A. Kasus-Jacobi, M. Lerner, A.M. Adesina and A.
Pereira. Univ. of Oklahoma Hlth. Sci. Ctr. and Baylor Col. of
Med.
A438
873.10 Opioid growth factor prevents relapses in mice
with relapsing-remitting EAE, a model for multiple sclerosis.
L.A. Hammer, I.S. Zagon and P.J. McLaughlin. Penn State
Col. of Med.
A439
873.11 Inflammatory cells and cytokines in the
olfactory bulb of a rat model of neuroinflammation: insights
into neurodegeneration?
M-F. Doursout, M.S. Schurdell,
L.M. Young, U. Osuagwu, D.M. Hook, B.J. Poindexter, M.C.
Schiess, D.L. Bick and R.J. Bick. Univ. of Texas Med. Sch. at
Houston.
A440
873.12 VP16-HCF interaction is required for herpes
simplex virus exit from latency in neurons in vivo.
N.M. Sawtell
and R.L. Thompson. Cincinnati Children’s Hosp. Med. Ctr. and
Univ. of Cincinnati Col. of Med.
A441
873.13 Depletion of PINK1 mediates mitochondrial
dynamics in chronic MPP+ toxicity.
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