321 t u e tuesday, april 23 Anatomy
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M. DeBaun and A. Doctor. Washington Univ. in St. Louis and Vanderbilt Univ. C182
mouse model. K. Mukherjee, L.L. Ballantyne, A. Sin, T. St. Amand and C.D. Funk. Queen’s Univ., Canada. C183
1009.3 Hyperargininemia in an inducible arginase-1- deficient mouse model. A. Sin, L.L. Ballantyne, K. Mukherjee, T. St. Amand, C. McCracken, V. Levandovskiy, A. Schulze and C.D. Funk. Queen’s Univ., Canada and The Hosp. for Sick Children, Toronto. C184
expression. J.M. Boylan, D.W. Lamming, N. Neretti, J. Ferreira, D.M. Sabatini and P.A. Gruppuso. Brown Univ. and Whitehead Inst. for Biomed. Res., Cambridge, MA. C185
of intracellular ferritin in mosquito cells. Z.R. Conley, D. Geiser and J. Winzerling. Univ. of Arizona. C186
1009.6 Structure of the carnitine palmitoyltransferase- 1A gene in rats, mice and humans. G.A. Cook and E.A. Park. Univ. of Hlth. Sci. Ctr. 1010. METABOLISM AND DIABETES Poster t ue . 7:30 am —B oston C onvention & e xhiBition C enter
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a-B Presentation time: 1:05 pm -2:35 pm C187
1010.1 Role of the sphingolipid biostat in pancreatic bcell apoptosis induced by gluco-lipotoxicity. N. Coant, J. Veret, P. Giussani, B. Portha, E.V. Berdyshev and H. Le Stunff. Univ. Paris Diderot, France, LITA-Segrate, Milan and Univ. of Illinois at Chicago. C188
1010.2 Small-molecule modulators of Nkx6.1 expression in pancreatic progenitor cells during directed differentiation of human embryonic stem cell to insulin producing beta cells. Q. Peterson and D. Melton. Harvard Univ.
TUESDAY BIOCHEMISTRY 336 C189
1010.3 Elevated hepatic fatty acid elongase-5 attenuates fatty liver in high fat diet induced obese mice. S. Tripathy, R.D. Stevens, J.R. Bain, C.B. Newgard and D.B. Jump. Oregon State Univ. and Duke Univ. Med. Ctr. C190
1010.4 Ultraviolet B radiation enhances glycation of human serum albumin and the formation of CML in vitro. W. Liu, M.A. Cohenford, L. Frost and J.A. Dain. Univ. of Rhode Island and Marshall Univ. C191
phosphorylation of sterol regulatory element binding protein and increases its activity in the development of atherosclerosis in pig and human diabetes. M. Zang, Y. Li, S. Xu, B. Jiang and R.A. Cohen. Boston Univ. Sch. of Med. C192
1010.6 The miR-696 contributes to insulin resistance by reducing mitochondrial function and antioxidant capacity in skeletal muscle cells.
Ribeirão Preto-Univ. of São Paulo. C193
we learned? A.E. Bunner and N.D. Barnard. Physicians Cmte. for Responsible Med., Washington, DC. C194
prevents vision loss in diabetic retinopathy. J.M. Cahoon, P.R. Olson, X.H. Zhang, M.M. Flood, B. Archer and B.K. Ambati. Univ. of Utah. C195
on dermal fibroblasts in type 1 diabetics. A.R. Jones IV, J.T. Deeney and B. Corkey. Boston Univ. Med. Ctr. C196
1010.10 Inhibition of mono-acyl-glycerol lipase by JZL- 184 results in glucolipotoxicity in pancreatic b-cells. C. Berdan,
C197
1010.11 Chronic exposure of clonal pancreatic b-cells
(INS-1 832/13) to pyruvate inhibits glucose-induced insulin secretion. N.E. Burritt, B. Corkey and J.T. Deeney. Boston Med. Ctr. C198
mobility disability elderly subjects. M.S. Lustgarten and R.A. Fielding. Tufts Univ., Boston. C199
1010.13 Iron stimulates insulin secretion in clonal pancreatic b-cells and dissociated rat islets. K.A. Erion, T.
C200
1010.14 Cystathionine- g-lyase (CSE) activation and H 2
transporter 4 translocation and glucose utilization in high glucose treated 3T3L1 adipocytes. P. Manna and S.K. Jain. LSU Hlth. Sci. Ctr., Shreveport. C201
hepatic steatosis and inflammation in diet-induced obesity. T. Geng, A. Sutter, D. Lewin, J. Ross, K.D. Chavin and L.A. Cowart. Med. Univ. of South Carolina. C202
1010.16 Hypoglycemia increases glycolytic metabolism in the rat ventromedial hypothalamus. J. Mun, A. Cooper, J. Cavaretta and J.L. Beverly. Univ. of Illinois, Urbana. C203
1010.17 Mesenchymal stem cell therapy to promote peripheral tissue insulin sensitivity in the high-fat fed, myocardial infarcted mouse.
Univ. of Calgary, Canada and Vanderbilt Univ. 1011. MITOCHONDRIA IN HEALTH AND DISEASE Poster t ue . 7:30 am —B oston C onvention & e xhiBition C enter
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a-B Presentation time: 1:05 pm -2:35 pm C204
1011.1 High fat feeding enhances the ability of mesenchymal stem cell therapy to modulate mitochondria in the infarcted heart.
Calgary, Canada and Vanderbilt Univ. C205
improves mitochondrial function in human placenta. R. Ramírez-Vélez. Univ. Manuela Beltrán, Colombia. C206
1011.3 Mitochondrial sensitivity to ADP in permeabilized fibers changed as a function of cardiac muscle compartments: left/right atria and ventricles of sheep heart.
Bordeaux Segalen Univ. C207
function and metabolism in the adult liver? C.J. Lagranha, R. Silva-Filho, C. Freitas, A. Silva, L. Nascimento, A.C. Leite, M.B. Maia and M.P. Fernandes. Fed. Univ. of Pernambuco, Vitoria de Santo Antão and Recife, Brazil. C208
hypertrophy through mitochondria: reciprocal interaction between AMPKk and angiotensin II type 1 receptor.
Rico.
C209 1011.6 Mammalian Ste20-like protein kinase 3 mediates the bioenergetics of mitochondria. C-J. Yuan and C-Y. Chen. Natl. Chiao Tung Univ., Taiwan. C210
1011.7 Palm fruit juice phenolics reduce the number of mutations caused by 3’-azido-3’-deoxythymidine treatment in a cultured human cell line.
C211
1011.8 Dietary avocado oil prevents the impairment in the complex III and ROS production in kidney mitochondria from diabetic rats by improving the electron flow through cytochrome c1. C. Cortes-Rojo, A. Saavedra-Molina, C.A. Samano-Garcia, O. Ortiz-Avila, E. Calderon-Cortes, D. Ortiz-Madrigal, G. Hernandez-Mata and A.R. Rodriguez- Orozco. Univ. Michoacana of San Nicolas de Hidalgo, Mexico. C212
1011.9 Using in-line probing to characterize pathogenic mutations in human mitochondrial tRNAs. B. Still, K. Her and J. Chihade. Carleton Col., MN. C213
1011.10 Using long-extension PCR assay to detect large-scale deletions in the mitochondrial DNA. W.K. Pogozelski, S. Chiappone, C. Evans and R. O’Donnell. SUNY Geneseo. C214
the mitochondrial genome is important for hypoxia-induced mitochondrial biogenesis in rat pulmonary artery endothelial cells.
M.V. Ruchko, O.M. Gorodnya, M.N. Gillespie and V.M. Pastukh. Univ. of South Alabama. C215
1011.12 Selective targeting of cytochrome C–cardiolipin complex to protect mitochondrial cristae and inhibit apoptosis. A.V. Birk, S. Liu, Y. Soong, J.D. Warren and H.H. Szeto. Weill Cornell Med. Col. C216
of sepsis. J.A. Crum and V. Del Gaizo Moore. Elon Univ., NC. Visit the Exhibits BIOCHEMISTRY TUESDAY 337 T U E C217
1011.14 Thiol-based antioxidants trigger transient mitochondrial oxidation. J.N. Beaudoin, V.L. Kolossov, W. Hanafin, S. DiLiberto, Jr., P.G. Kenis and H.R. Gaskins. Univ. of Illinois at Urbana-Champaign. C218
ROS generation in liver and aortic mitochondria from diabetic rats.
de San Nicolas de Hidalgo, Mexico. 1012. NUCLEAR RECEPTORS IN METABOLIC SYNDROMES Poster t ue . 7:30 am —B oston C onvention & e xhiBition C enter
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a-B Presentation time: 1:05 pm -2:35 pm C219
1012.1 Association of genetic polymorphism of peroxisome proliferator-activated receptor-gamma gene and polycystic ovary syndrome.
Arab Emirates. C220
IIa by thyroid hormone. P. Sharma, S. Thakran, X. Deng, M.B. Elam and E.A. Park. Univ. of Tennessee Hlth. Sci. Ctr., Memphis.
C221 1012.3 Retinoid X receptor alpha interaction with sugars.
F.L. Soman, C. de Jesus Piva and H.A. Hostetler. Boonshoft Sch. of Med., Wright State Univ. 1013. ASSEMBLY AND CONTROL OF DYNAMIC PROTEIN COMPLEXES Poster t ue . 7:30 am —B oston C onvention & e xhiBition C enter
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a-B Presentation time: 1:05 pm -2:35 pm C222
1013.1 Crystal structure and in vitro analysis of human IQGAP1 calponin homology domain: implication for its interactions with Ca 2+ bound calmodulin and F-actin. J. Liu, V. Kurella, L.F. LeCour and D.K. Worthylake. LSU Sch. of Med.,New Orleans. C223
BLIP-II and Staphylococcus aureus PBP2a. C.J. Adamski, D-C. Chow, N. Brown and T. Palzkill. Baylor Col. of Med. C224
1013.3 GMPCPP and paclitaxel effect on microtubule stiffness. S. Cheng and Z. Donhauser. Vassar Col. C225
1013.4 Monitoring the structural dynamics of LRRK2 using split-luciferase protein-fragment-assisted complementation.
t ue . 7:30 am —B oston C onvention & e xhiBition C enter
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a-B Presentation time: 1:05 pm -2:35 pm C226
1014.1 Tissue culture of the Egyptian cotton cultivars: production and morphological heterogeneity of primary callus tissues.
Alexandria Univ., Egypt. C227
tyrosinase activity and melanin synthesis. Y.H. Lee, B.H. Yoon and M.J. Ku. Kosin Med. Col. and Tongmyong Univ., South Korea.
C228 1014.3 Synthesis of novel Pb, Mn, Zn, Ag, Co and Cu complexes with coumarine derivative moiety and their antibacterial activities.
of Prishtina, Kosovo. C229
subchronic toxicity (in rats) of aqueous extract of Tapinanthus bangwensis leaves grown on orange trees. S.C. Nwoke, A.O. Magbagdeola,, A.O. Ebuehi, N.A. Imaga, M. Omojufehinsi, S. Gbotolorun,, G.O. Ajayi, and A. Ani. Univ. of Lagos, Nigeria. C230
1014.5 The biogeochemical chlorine cycle in forest ecosystems. A. Pirovano and A. Leri. Marymount Manhattan Col.
C231 1014.6 Sensitization of NCI-H460 cells to anticancer drugs with aminoglycosides. M. Cuccarese. Northeastern Univ.
C232 1014.7 Structure activity relationship study of the cleistriosides and cleistetrosides for antibacterial/anticancer activity.
C233
1014.8 C3’/C4’-stereochemical effects of digitoxigenin a-L-/a-D-glycoside in cancer cytotoxicity. S. McKenna and J. Hinds. Northeastern Univ. C234
1014.9 Synergistic effects of digitoxin analogues in combination with chemotherapeutic drugs. J.W. Hinds and S. McKenna. Northeastern Univ. C235
1014.10 Effects of aloe vera components on the renin- angiotensin system in human mesangial cells. L.S. Arita, L. Santos, R. Yokota, M.M. Tanae, D.S. Aragão, M.D. Nogueira, R.S. Banchi, L.E. Matsumoto, D.Y. Arita, T.S. Cunha, M.T.R. Lima-Landman and D.E. Casarini. Fed. Univ. of São Paulo and Tulane Univ. 1015. PROTEIN-SMALL MOLECULE INTERACTIONS Poster t ue . 7:30 am —B oston C onvention & e xhiBition C enter
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a-B Presentation time: 1:05 pm -2:35 pm C236
1015.1 Understanding protein-protein interaction network: a case study with glutaminase interacting protein. M. Ovee, D. Zoetewey, M. Banerjee, R. Bhaskaran, S. Mohanty, S. Zencir and Z. Topcu. Auburn Univ. and Ege Univ., Turkey. TUESDAY BIOCHEMISTRY 338 C237
1015.2 Specific interaction of the TCERG1 FF4-6 tandem repeat domains with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5 and Ser7 of the CTD.
J. Liu, S. Fan, C-J. Lee, A.L. Greenleaf and P. Zhou. Duke Univ. Med. Ctr. and MRC Lab. of Molec. Biol., Cambridge, U.K. C238
1015.3 Homogeneous, sulfated oligosaccharides from glycosaminoglycans activate promatrilysin (proMMP-7) largely by co-localization.
Polytech Inst. C239
C240
1015.5 The relationship between function and structure of the heme-scavenging protein IsdX1. A. Kenrick, K. Polzin and M. McEvoy. Univ. of Arizona. C241
1015.6 Guanosine-5’-triphosphate regulates the interaction between MciZ and FtsZ. S. Ray, A. Kumar and D. Panda. Indian Inst. of Technol. Bombay. C242
1015.7 Structure-based drug design of inhibitors of the CD23 and immunoglobulin E interaction. M.O.Y. Pang, J. McDonnell and A. Beavil. King’s Col. London. C243
1015.8 Design and characterization of an EHD1 inhibitor. J. Baleja, T. Corlin, A. Kamens, A. Alt-Holland and J. Kritzer. Tufts Univ. Schs. of Med. and Dent Med. and Tufts Univ.
C244 1015.9 The effect of conformational changes on non-coordinated water occupancy associated with R and T allosteric states of carp hemoglobin.
Francisco State Univ. and Univ. of California, Santa Cruz. 1016. CELL AND ORGANELLE DYNAMICS Poster t ue . 7:30 am —B oston C onvention & e xhiBition C enter
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a-B Presentation time: 12:25 pm -1:55 pm C245
1016.1 The role of the C-terminus and transmembrane segments in facilitating atlastin-mediated endoplasmic reticulum fusion.
HHMI, Col. of Life Sci., Nankai Univ. and Tianjin Key Lab. of Protein Sci., Tianjin, China and NIDDK, NIH. C246
1016.2 Saccharomyces cerevisiae Env7 is a novel serine/threonine kinase 16-related protein kinase and negatively regulates organelle fusion at the lysosomal vacuole.
California State Univ., Long Beach. C247
zone mediated by sub-regional co-existing CCL19 and CCL21 fields in lymph nodes.
Univ. of Manitoba. 1017. MEMBRANE TRANSPORT Poster t ue . 7:30 am —B oston C onvention & e xhiBition C enter
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a-B Presentation time: 12:25 pm -1:55 pm C248
1017.1 Mechanisms of Cu + transfer from soluble Cu + chaperones to transmembrane transport ATPases. T.N. Padilla-Benavides, C.J. McCann and J.M. Arguello. Worcester Polytech Inst. C249
+3 /phytosiderophore transporter isolated from oats (Avena sativa). G.T. Davis and M. Stocksdale. Bloomsburg Univ., PA and Earlham Col., IN. C250
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