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80,000 > 80,000 ~2,000 added/year
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tarix | 01.04.2017 | ölçüsü | 445 b. | | #13152 |
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> 80,000 > 80,000 ~2,000 added/year ~8,000 are carcinogens No toxicity data for ~40% of the 3,300 “high production volume” chemicals Full toxicity data for only 25% of chemicals in consumer products
Exploring environment-gene-disease connections Exploring environment-gene-disease connections
EPA Superfund EPA Superfund EPA ToxCast NTP Users/Collaborators
~190,000 transitive inferences between chemicals and diseases Transitive Inference - If ‘A’ interacts with ‘B’ and ‘C’ interacts with ‘B’, then infer that ‘A’ interacts with ‘C’
How to assess which inferences are “good” or not?
Characterizing these chemicals - Structure
- Regulatory features (e.g., High production, Carcinogen)
- Function (e.g., Associated pathways)
- Other associated diseases (e.g., Neurological)
Tag Clouds Text mining Gene Ontology enrichment analysis
Analysis tools and visualization capabilities Integration of additional data sets (SNPs, Chemical codes) Exposure data curation
Develop exposure ontology Define scope of data to be curated Test curation protocol
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