80,000 > 80,000 ~2,000 added/year



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tarix01.04.2017
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#13152



> 80,000

  • > 80,000

  • ~2,000 added/year

  • ~8,000 are carcinogens

  • No toxicity data for ~40% of the 3,300 “high production volume” chemicals

  • Full toxicity data for only 25% of chemicals in consumer products







Exploring environment-gene-disease connections

  • Exploring environment-gene-disease connections





EPA Superfund

  • EPA Superfund

  • EPA ToxCast

  • NTP

  • Users/Collaborators



























~190,000 transitive inferences between chemicals and diseases

  • ~190,000 transitive inferences between chemicals and diseases

  • Transitive Inference

    • If ‘A’ interacts with ‘B’ and ‘C’ interacts with ‘B’, then infer that ‘A’ interacts with ‘C’
  • How to assess which inferences are “good” or not?

























Characterizing these chemicals

  • Characterizing these chemicals

    • Structure
    • Regulatory features (e.g., High production, Carcinogen)
    • Function (e.g., Associated pathways)
    • Other associated diseases (e.g., Neurological)


Tag Clouds



Analysis tools and visualization capabilities



Develop exposure ontology





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