Saat/Hours
11 Nisan Pazartesi / April 11th, Monday
09:00-09:45
(Salon A / Hall A)
Oturum Başkanları / Moderators: Pekcan Ungan, Emre Öge
Konferans 5 / Conference 5
Brain oscillations, neuromodulation and memory in and out of sleep
Susan J. Sara
09:45-10:30
Konferans 6 / Conference 6
Robotlar İnsanlardan Neler Öğrenebilir?
What Can Robots Learn from Humans?
Levent Akın
10:30-11:00
Kahve Arası / Coffee Break
11:00-12:30
(Salon A / Hall A)
Panel 7
Beyin Osilasyonları ve Klinik Uygulamaları
Brain Oscillations and Their Clinical Applications
Oturum Başkanı/Moderator: Erol Başar
Event related oscillations and event related coherence in healthy subjects
Bahar Güntekin
Event related oscillations and event related coherence in euthymic patients with
bipolar disorder
Ayşegül Özerdem
Event related oscillations and event related coherence in patients with alzheimer’s
disease
Görsev G.Yener
Selective gamma activation in alzheimer’s disease, bipolar disorder and
schizophrenia
Erol Başar, Canan Başar-Eroğlu, Bahar Güntekin, Ayşegül Özerdem, Görsev G.
Yener
11:00-12:30
(Salon B / Hall B)
Panel 8
Epilepside Aktarımsal Sinirbilim
Translational Neuroscience in Epilepsy
Oturum Başkanı/Moderator: Filiz Onat
Altered information processing in dendrites in epilepsy
Christophe Bernard
Talamus’un epileptik network'de rolü / The role of thalamus in epileptic network
Safiye Çavdar
EPICURE as an FP7 project
Giuliano Avanzini
12:30-14:00
Öğlen Yemeği / Lunch
14:00-15:30
(Salon A / Hall A)
Sözel Sunumlar 5 / Oral Presentations 5
Elektrofizyoloji ve Bilgisayımsal Sinirbilim
Electrophysiology and Computational Neuroscience
Oturum Başkanları/Moderators: Ümmühan İşoğlu-Alkaç, Adnan Kurt
BlueSpike: Beyin-makine arayüzü deneyleri için açık kodlu veri toplama ve
çevrimiçi sinirsel iğnecikleri sınıflandırma sistemi yazılımı / BlueSpike: An online
data acquisition and neural spike processing platform for brain machine interface
Bilimsel Program / Scientific Program
12
engineering experiments
Mehmet Kocatürk, Halil Özcan Gülçür, Reşit Canbeyli
Beyin kaynaklı nörotrofik faktör (BDNF) heterozigot fare korteksinde
GABAerjik salınım özellikleri ve EEG analizi / GABAergic release properties and the
EEG analysis in the cortex of Brain Derived Neurotrophic Factor (BDNF)
heterozygous mice
İsmail Abidin, Mehmet Yıldırım, Selcen Aydın-Abidin, Ersan Kalay, Ali Cansu,
Metehan Akça, Ulf T. Eysel, Thomas Mittmann
Akut inme, kortikomusküler koheransa katkıda bulunan kortikal nöronal
osilasyonların merkez frekansını düşürmektedir. / Acute stroke slows the center
frequency of cortical neuronal oscillations contributing to cortico-muscular
synchronization.
Zübeyir Bayraktaroğlu, Katherina von Carlowitz-Ghori, Florian Losch, Gabriel
Curio, Vadim V. Nikulin
Kısa süreli bellek ile ilişkili elektriksel salınımların hemodinamik karşılıklarının
analizi / Analysis of hemodynamic correlates of electrical oscillations related with
short-term memory
Itır Kaşıkçı, Ali Bayram, Başar Bilgiç, Tamer Demiralp
Görsel oddball paradigmasında el tercihi etkisinin değerlendirilmesi / Evaluation of
the effects of hand preference on visual oddball paradigm
Gökçer Eskikurt, Ümmühan İşoğlu-Alkaç
Kortiko-striato-talamik devrelerin bir robot uygulaması / Implementation of
cortico-striato-thalamic circuits on robot
Berat Denizdurduran, Neslihan Serap Şengör
14:00-15:30
(Salon B / Hall B)
Sözel Sunumlar 6 / Oral Presentations 6
Epilepsi - Sinirbilim öğretimi
Epilepsy - Neuroscience Education
Oturum Başkanları/Moderators: Güldal Güleç, Müge Devrim
Genetik absans epilepsi sıçan modelinde amigdala kindling sürecinin tek bir nöron
ateşlemesi üzerine etkisinin incelendiği in-vivo çalışma / In-vivo study of the
impact of amygdala kindling on the firing pattern of single neuron in a genetic
absence epilepsy rat model
Nihan Çarçak, Filiz Onat, Didier Pinault, Terence J. O’Brien
Genetik absans modellerinin sekonder jeneralizasyona direnç göstermelerinin
altında yatabilecek olası mekanizmalar / Possible underlying mechanisms of
resistance to secondary generalization in genetic absence rat models
M.Tansel Kendirli, Filiz Onat, Edward H. Bertram
Tekrarlanan travmatik beyin hasarında epileptogenez ve kan-beyin bariyeri /
Epileptogenesis and blood-brain barrier integrity in repeated traumatic brain
injury
Nurcan Orhan, Nadir Arıcan, Oğuzhan Ekizoğlu, İmdat Elmas, Bülent Ahıshali,
Mutlu Küçük, Candan Gürses, Mehmet Kaya
Sıçanlarda epileptiform aktivite üzerine pinealektomi ve ekzojen melatoninin etkisi
/ Influence of pinealectomy and exogenous melatonin on epileptiform activity in
rats
Mehmet Yıldırım, İsmail Abidin, Sinan Canpolat, Selcen Aydın-Abidin, Metehan
Akça, Ali Cansu
Büyük bir nöron havuzunda epileptik nöbet olmamasını garanti eden koşullar –
Kuramsal bir çalışma / Conditions that guarantee nonexistence of epileptic
Bilimsel Program / Scientific Program
13
seizures in a large pool of neurons - A theoretical study
H.Özcan Gülçür
İnsan işitme sisteminin yapisal ve işlevsel özelliklerinin 3 boyutlu simülasyonu /
3D simulation of the structural and functional properties of the human auditory
system
Merve Evren, Vedat Evren, Ersin O. Koylu
15:30-16:00
Kahve Arası / Coffee Break
16:00-17:00
(Poster Salonu / Poster Hall)
Poster Sunumları 3 / Poster Presentations 3
Nöroanatomi; Nöroşirurji; Sinaptik İletim; Epilepsi; Dejenerasyon-Rejenerasyon;
Serebrovasküler Sistem; Sinirbilim Öğretimi
Neuroanatomy; Neurosurgery; Synaptic Transmission; Epilepsy; Degeneration-
Regeneration; Cerebrovascular System; Neuroscience Education
Oturum Başkanları/Moderators: Ersin Koylu, Ümmühan İşoğlu-Alkaç, Mehmet
Kaya, Ferhan Esen
Poster 95 - Poster 138
17:00-18:30
(Salon A / Hall A)
Panel 9
Alzheimer Hastalığında Nörobiyolojik, Genetik ve Tanısal Güncelleme
Neurobiological, Genetic and Diagnostic Update in Alzheimer's Disease
Oturum Başkanı/Moderator: Murat Emre
Alzheimer hastalığının nörobiyolojisi üzerine bir güncelleme / An update on the
neurobiology of Alzheimer's disease
Hakan Gürvit
Alzheimer Hastalığının Genetik Temelleri / The genetic basis of Alzheimer’s
disease
Selma Yılmazer
Alzheimer hastalığının erken tanısına ilişkin yenilikler / New developments in the
early diagnosis of Alzheimer’s disease
Başar Bilgiç
17:00-18:30
(Salon B / Hall B)
Panel 10
Madde Bağımlılığı ile Şizofreni Arasındaki İlişkinin Nörobiyolojik Temelleri
Neurobiological Basis of the Relationship between Schizophrenia and Substance
Dependence
Oturum Başkanı/Moderator: İ. Tayfun Uzbay
Şizofreni ile madde bağımlılığı arasındaki ilişkinin nörobiyolojik temelleri – Giriş /
Neurobiological basis of the relationship between schizophrenia and substance
dependence – Introduction
İ. Tayfun Uzbay
Şizofreni hastalığında sigara kullanımı ve nikotinik reseptörler / Smoking and
nicotinic receptors in schizophrenia
Gökhan Göktalay
Madde bağımlılığı ile şizofreni arasındaki ilişkinin nörobiyolojik temelleri: deneysel
bulgularımız / Neurobiological basis of the relationship between substance
dependence and schizophrenia: Our experimental findings
Hakan Kayır
Atipik antipsikotiklerin sıçanlarda alkol yoksunluk sendromu üzerine etkileri /
Bilimsel Program / Scientific Program
14
Effects of atypical antipsychotic drugs on ethanol withdrawal syndrome in rats
İpek Komşuoğlu-Çelikyurt
19:30-23:00
Gala Yemeği / Gala Dinner
Saat/Hours
12 Nisan Salı / April 12th, Tuesday
09:00-09:45
Oturum Başkanları/Moderators: Çiğdem Özkara, Sacit Karamürsel
Konferans 7 / Conference 7
Neuroscience and Music
Giuliano Avanzini
09:45-10:30
Konferans 8 / Conference 8
Applications of EEG-based Brain Computer Interfaces for the Control of Electronic
Devices: the Rome Experience
Fabio Babiloni
10:30-11:00
Kahve Arası / Coffee Break
11:00-12:30
Kapanış Töreni / Closing Ceremony
Oturum Başkanları/Moderators: Sacit Karamürsel - Hakan Gürvit
12:30-14:00
Öğlen Yemeği / Lunch
14:00-
Sosyal Program / Social Program
KONFERANSLAR / CONFERENCES
Konferanslar -/ Conferences
16
KONFERANS 1 / CONFERENCE 1
The logics of networks in motion - from ion channels to behaviour
Sten Grillner
Karolinska Institutet, Nobel Institute for Neurophysiology, Department of Neuroscience, Stockholm, Sweden
In all vertebrates from primates to fish and lamprey, the basic neuronal organization controlling patterns of
motor behaviour such as locomotion, breathing, and posture are organized in a similar or identical way. These
networks form a motor infrastructure used that define all movements that each species can perform. These
networks in turn can be selected through subpopulations of cells in the basal ganglia, which play an important
role for the selection of motor programs. The design of the basal ganglia circuits are conserved in considerable
detail throughout vertebrate evolution from lamprey to primates through more than 500 million years. The
networks generating the locomotor movements are located in the spinal cord.
They are responsible for the sequential activation of the different limb muscle in each locomotor cycle. The
activity level is controlled by locomotor command centres in the brainstem, also conserved throughout the
vertebrate phylum. To elucidate the intrinsic function of these pattern generating networks and command
systems we have developed the lamprey nervous system as an experimental model, in which we now
understand the cellular bases of the brainstem spinal cord networks generating goal-directed locomotion and
control of body orientation. The detailed synaptic interaction has been identified, as well as the network
contribution of subtypes of ion channels.
KONFERANS 2 / CONFERENCE 2
Thalamus and cortex in relation to action and perception
Ray Guillery
University of Oxford, Medical Research Council (MRC), Anatomical Neuropharmacology Unit, Oxford, UK
The thalamus is generally treated as a gateway to the cortex that relays to specialized cortical areas
information from sensory receptors and from other brain regions such as the cerebellum or mamillary bodies.
However, these ‘first order’ relays represent only a limited part of the thalamus. A large, ‘higher order’ part of
the thalamus is concerned with relaying information from one cortical area to another. Essentially all thalamic
relays, both first and higher order, receive their inputs for relay to cortex from axons that are branched, with
one branch going to lower motor centres or pattern generators and the other going to the thalamus. These
connectional patterns show that the thalamus is sending to cortex information about ongoing instructions that
are currently being passed, from the outside world or from other parts of the brain, to the lower motor centers.
Essentially all cortical areas receive thalamic inputs and send descending, motor outputs to lower centers. The
transthalamic inputs to cortex and the corticofugal outputs thus all represent ongoing sensorimotor
interactions. The thalamic gate may serve to arouse cortex when the messages that are passing to the lower
motor centers are not following an ‘expected’ routine, allowing cortex to over-ride lower ongoing mechanisms.
Konferanslar -/ Conferences
17
KONFERANS 3 / CONFERENCE 3
The Berlin Brain-Computer interface (BBCI)
Gabriel Curio
Charité - University Medicine Berlin, Department of Neurology and Clinical Neurophysiology, Berlin, Germany
‘To make matter move just by thinking about it’ – yesterday’s fiction is turning into today’s science: A major
motivation for developing BCIs is to help tetraplegic patients, e.g., in locked-in syndrome. BCI systems use
their preserved mental capacities to make up for lost physical abilities. The principle works in three steps: 1)
brain activity is recorded during intended movements; 2) user-specific computer programs extract ‘thought-
related’ patterns; and 3) these patterns are categorized to control technical devices in real-time. Many BCI
strategies are explored, including non-invasive EEG recordings, invasive electrocorticography, and intracortical
recordings from hundreds of single neurons. These options will enable future BCI users to decide on their
personal balance between innocuous but moderately precise non-invasive systems and the higher precision of
invasive decoding systems carrying risks of intracranial bleeding and infection. One non-invasive approach is
the Berlin Brain-Computer Interface (www.bbci.de); its machine-learning algorithms use diverse EEG signs of
intended movements such as slow ‘readiness-potentials’ and movement-related attenuation of EEG ‘idling
rhythms’ in brain motor areas. Studies of long-term amputees show that such EEG signs are usually preserved
when people try to move a ‘phantom hand’. BCI feedback settings include controlling computer cursors, ‘mental
typewriters’, gaming applications, and virtual prostheses. These evolving concepts can be put not only to
medical and but also to neuroergonomic use. As BCI applications move toward ever more futuristic fantasies,
both scientists and the public at large should be aware of the ethical implications of this novel man-machine
interface.
KONFERANS 4 / CONFERENCE 4
Learning, motivation and the basal ganglia
Ann Graybiel
Massachusetts Institute of Technology, Cambridge, USA
The same brain that can construct language, music and mathematics also lets us develop habits of thought and
action. These semi-automatic routines free us to think and attend to the world. But the habit system can also
be hijacked by disease and drug exposure. This lecture will focus on the habit system of the brain and our
remarkable ability to switch from conscious activity to nearly non-conscious behavior. The lecture will highlight
research directed towards understanding how we make and break habits and how the neurobiology of the habit
system is helping to advance understanding of human problems ranging from Parkinson’s disease to obsessive-
compulsive spectrum disorders and addiction. This research supports the view that basal ganglia-based circuits
can build representations of habits, and that the laying down of such representations involves genes expressed
in basal ganglia-related networks. Disorders of such basal ganglia plasticity could contribute to behavioral fixity
and difficulty of initiation of behavior, as in Parkinson’s disease, or to the excessive release of behaviors, as in
Huntington’s disease, or to the repetitive behaviors and thoughts characteristic of many neuropsychiatric
disorders. The basal ganglia thus may influence not only motor pattern generators, but also cognitive pattern
generators.
Konferanslar -/ Conferences
18
KONFERANS 5 / CONFERENCE 5
Brain oscillations, neuromodulation and memory in and out of sleep
Susan J. Sara
Laboratoire de Physiologie de la Perception et de l'Action (LPPA), Collège de France, Paris
Contemporary views of memory concur that consolidation far outlasts the initial learning experience and is a
process that can be reinitiated over and over again. This view has found support in recent human literature
documenting the importance of sleep for memory. Rodent experiments, showing 'replay' during sleep of
neuronal ensembles activated by a waking experience, lend even further support. Pharmacological studies from
our laboratory implicated the noradrenergic system in a late stage of memory consolidation. Subsequent
electrophysiological studies revealed that noradrenergic neurons of the Locus Coeruleus (LC), normally
quiessent during sleep, show a burst of activity during slow wave sleep after a learning experience. This finding
has led to further investigation of the relation between LC activity and forebrain oscillations during sleep that
may be promoting memory consolidation. We have discovered that LC neurons are time-locked to cortical slow
oscillations and bear a temporal relation to cortical spindles.
KONFERANS 6 / CONFERENCE 6
Robotlar insanlardan neler öğrenebilir?
H. Levent Akın
Boğaziçi Üniversitesi, Bilgisayar Mühendisliği Bölümü, İstanbul
Yapay zekâya sahip robotlar yavaş yavaş gündelik yaşamımızı paylaşmaya başlıyorlar. Bu robotlardan değişik
beklentilerimiz var. Bizlere hizmet etmek dâhil çok çeşitli alanlarda çalışmalarını istiyoruz. Bunu
gerçekleştirmeye çalıştığımızda karşımıza cevaplanması gereken birçok soru çıkıyor: robotlar yapacakları işleri
nasıl yapacaklarını nereden bilecekler, bildikleri durumların dışındaki bir durumda nasıl davranacaklar? Robotlar
1950lerden beri giderek daha yoğun şekilde yapay zeka teknikleri ile programlanarak kullanılmaktaydı.
Yapılacak görevlerin zorluğu arttıkça robotların gerekli becerileri ve görevleri kendi kendilerine öğrenmesi
gündeme gelmiştir. Ne var ki, basit bir becerinin öğrenilmesi ile bir görevin adımlarının öğrenilmesi farklı
tekniklerin kullanılmasını gerektirmektedir. Bu nedenle psikoloji ve sinirbilimdeki gelişmelerden esinlenen birçok
yöntem günümüzde bu alanda kullanılmaya başlanmıştır. İnsanlar üstünde yapılan çalışmalar sonucunda
geliştirilen algılama ve bellek modelleri de yeni kuşak robotların geliştirilmesini giderek kolaylaştırmaktadır. Bu
konuşmada robotların deneme yanılma ile pekiştirmeli öğrenme, gösteriden öğrenme gibi yaklaşımlarla
insanlardan neleri nasıl öğrenebilecekleri konusundaki çalışmalar özellikle futbol oynayan robotlardan örnekler
verilerek sunulacaktır.
What can robots learn from humans?
Robots with artificial intelligence have gradually begun being a part of our everyday lives. We have different
expectations of such robots. We want them to work in a wide variety of fields including serving us. While trying
to achieve this, we are confronted with many questions that need to be answered: How will the robots know
how to do what they are supposed to do, how will they behave in unfamiliar situations? Since the 1950s, robots
have been used in a programmed fashion with the utilization of artificial intelligence techniques gradually
increasing. As the difficulty of the tasks the robots must do increase, the need for the robots to learn the
necessary skills on their own have become apparent. However, learning a simple skill and learning the steps of
a task require the use of different techniques. For this reason, recently, many methods inspired from the
developments in psychology and neuroscience have begun to be used in this field. Perception and memory
models developed as a result of the studies on humans increasingly facilitate the development of a new
generation of robots. In this talk, what robots can learn from humans using approaches such as reinforcement
learning by trial and error and learning from demonstration will be presented giving examples from the domain
of soccer playing robots.
Konferanslar -/ Conferences
19
KONFERANS 7 / CONFERENCE 7
Neuroscience and music
Giuliano Avanzini
Istituto Nazionale Neurologico Carlo Besta, Milano, Italy
In the last decade the investigations on cerebral organization of musical competences gained a particular
impetus that led to significant advances in our understanding. Cortical areas that process the musical input
have been identified in temporal lobe, in close proximity with primary auditory area, but not coincident with it.
By functional imaging several hierarchically organized areas dealing with the recognition of a given acoustic
stimulus as noise, as tune and as tune sequence have been mapped in the first temporal gyrus. Moreover the
effect of cortical lesions on music perception has been analyzed in patients who underwent tailored temporal
lobe resections for treatment of drug resistant epilepsies. It was so possible to demonstrate that depending on
the topography of the resection selective impairment of the melodic contour, key, musical intervals, meter and
rhythm could be observed.
Particularly interesting is the discovery of the prominent role of Broca area in processing musical sounds. The
results of several studies demonstrate that the Broca area is contributing in syntactic organization of musical
elements as it does for the linguistic ones. Furthermore a similar role is played by Broca area in motor
programming suggesting that the integrating activity of this cortical region goes far beyond the linguistic
domain.
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