Rh Immune Response Formation of Anti-Rh Agglutinins.
When red blood cells containing Rh factor are injected into a
person whose blood does not contain the Rh factor—that is, into an Rh-negative person—anti-Rh
agglutinins develop slowly, reaching maximum concentration of agglutinins about 2 to 4 months later.
This immune response occurs to a much greater extent in some people than in others. With multiple
exposures to the Rh factor, an Rh-negative person eventually becomes strongly ―sensitized‖ to Rh
factor.
