Organizing co mmittee

 
 
 
 
 
 

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Oral presentation 
32 
NATURAL NEUROTROPIC AUTOANTIBODIES IN COVID-19 
ASSOCIATED WITH ISCHEMIC STROKES 
 
M.A. Rasulova, Kh.A. Rasulova 
 
Tashkent Pediatric Medical Institute 
Although considerable progress has been made in the understanding of immune 
mechanisms of development of acute ischemic stroke (IS), the clinical outcome of 
patients with COVID-19 associated IS is significantly influenced by the inflammatory 
response and neuroimmunological disorders.
Totally 80 patients with acute first-ever IS were included consecutively, who were 
divided into two groups: 50 patients with COVID-19 associated IS and pneumonia (1 
group) and 30 patients with IS without COVID-19 positive test (2 group). The stroke 
severity and consciousness were measured by the NIHSS and Glasgow coma scale. In 
blood serum of all patients were studied the levels of natural IgG autoantibodies (Nabs) 
to NF-200, GFAP, S100β, MBP, receptors to dopamine, serotonin, choline, glutamate, 
GABA by Poletaev’s enzyme immunoassay method. Serum samples of 16 healthy 
individuals matched by age and gender were used as control.
Mild stroke (NIHSS < 5) was found out in 29% patients, moderate stroke (NIHSS 
16-20) in 25%, severe stroke (NIHSS 21-42) – in 46%. 8 patients died at acute stage. In 
1 group, Nabs levels increased to NF-200 (132.9±2.8 CU) in 1.09 and 1.8 times, GFAP 
(118.9±3.9 CU) in 1.4 and 2 times, S100β (129.5±10.2 CU ) in 1.05 and 1.6 times, MBP 
(97.3±4.5 CU) in 1.14 and 
1.6 
times, to receptors to dopamine (77.9±4.4 CU) in 1.2 
times and 1.6 times, serotonin (81.96±3.25 CU
) in 1.2 and 1.4 times, 
choline 
(61.42±3.6CU) 1.4 and 1.8 times, glutamate (85,28± 4,25CU) in 1.19 and 1.4 times, 
GABA 
(82,4
±
12,7 CU)
in 
1.5 and 1.8 times,
respectively, in comparison with the same 
parameters in 2 group and control. 
In 2 group, Nabs levels increased to NF-200 (121.56±2.8 CU) in 1.6 times, GFAP 
(82.7±3.42 CU) in 1.1 times, S100β (122.8±4.9 CU) in 1,5 times, MBP (85.56±3.4 CU) 
in 1.4 times, receptors to dopamine (63,16 ±3.8 CU) in 1.3 times, serotonin (63.8 ± 2.8 
CU) in 1.1 times, choline (42.23±1.8 CU) in 1.2 times, glutamate (71.26±4.0 CU) in 1.2 
times, GABA (53.3±3.3CU) in 1.1 times, in comparison with control group. 
Autoimmune processes have the certain place in the pathogenesis of ischemic 
strokes, especially on the background of COVID-19 infection. The degree and duration 
of increase in the levels of Nabs have the prognostic significance for the evaluation 
severity degree of stroke course that could be an additional criterion in the integrated 
diagnosis and timely correction of treatment for this disease.