Test and treat for Helicobacter pylori (HP) in dyspepsia


QUICK REFERENCE GUIDE AUTHORS



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QUICK REFERENCE GUIDE AUTHORS
Prof Cliodna McNulty, Head of Primary Care Unit and Honorary Visiting Professor, Public Health England and Cardiff University

Dr Philippa Moore, Consultant Microbiologist, Gloucestershire Hospitals NHS Foundation Trust

Dr Teh Li Chin, Consultant Microbiologist, North Bristol NHS Trust

Dr Gerry Morrow, Clinical Editor, Clinical Knowledge Summaries

Sarah Alton, Guidance Research Assistant, Public Health England
QUICK REFERENCE GUIDE REVIEWERS
Dr Mahableshwar Albur, Consultant Microbiologist, North Bristol NHS Trust

Alice Alcock, Senior Biomedical Scientist, University Hospitals of North Staffordshire NHS Trust

Prof John Atherton, Professor of Gastroenterology, University of Nottingham

Elizabeth Beech, Prescribing Advisor, NHS Bath and North East Somerset Clinical Commissioning Group

Dr John Cheesbrough, Consultant Microbiologist, Teaching Hospitals NHS Foundation Trust

EY Cheung, Deputy Head of Medicines Management, NHS Camden Clinical Commissioning Group

Dr David Clements, Consultant Physician/Gastroenterologist, Airedale NHS Foundation Trust

Alison Dossetter, Senior Pharmaceutical Advisor, NHS East and North Hertfordshire Clinical Commissioning Group

Dr Paul Edelstein, Director of Clinical Microbiology, Hospital of the University of Pennsylvania

Prof Emad El-Omar, Professor of Gastroenterology, Aberdeen University

Dr Keith George, Senior Consultant Gastroenterologist, Torbay and South Devon NHS Foundation Trust

Dr Gauri Godbole, Consultant Medical Microbiologist, Public Health England

Dr Andrew Goddard, Consultant Gastroenterologist, Royal College of Physicians

Dr Stephen Grainger, Consultant Gastroenterologist, Spire Roding Hospital

Dr Katherine Groves, Consultant Microbiologist, Homerton University Hospital Foundation Trust

Jyoti Gupta, Senior Prescribing Advisor, NHS Camden Clinical Commissioning Group

Dr Diane Harris, Lead Antimicrobial Pharmacist, NHS Southern Derbyshire Clinical Commissioning Group

Hazel Steele, Specialist Pharmacist – Antimicrobials (Primary Care), NHS Tayside

Dr Brendan Healy, Consultant in Microbiology and Infectious Diseases, Public Health England

Dr Mathis Heydtmann, Consultant Hepatologist and Gastroenterologist, NHS Greater Glasgow and Clyde

Dr Simon Hill, Consultant Microbiologist/Director of Infection Prevention and Control, Poole Hospital NHS Foundation Trust

Prof Amanda Howe, Professor of Primary Care, University of East Anglia

Dr Subash Jayakumar, General Practitioner, NHS Brent Clinical Commissioning Group

Hannah Jones, Practice Pharmacist, IntraHealth

Dr Priya Khanna, Consultant Microbiologist, London North West Healthcare NHS Trust

Suzanne Lever, Pharmaceutical Advisor, Barnet Clinical Commissioning Group

Michelle Liddy, Regional Technical Advisor, National Institute for Health and Care Excellence

Hao Lu, Pharmacy Manager, United Family Healthcare

Ayuen Lual, Features Editor, Society for Applied Microbiology

Brian MacKenna, Deputy Head of Medicines Management, NHS Islington Clinical Commissioning Group

Dr Sarah Meisner, Consultant Microbiologist, Royal United Hospitals NHS Foundation Trust

Dr Alastair Miller, Consultant Physicians, Royal Liverpool and Broadgreen University Hospitals NHS Trust

Layla Mohammadi, Lead Pharmacist – Antimicrobials, Lewisham and Greenwich NHS Trust

Dr Rohinton Mulla, Lead Consultant Medical Microbiologist, Luton and Dunstable Hospital NHS Foundation Trust

Dr Aaron Nagar, Consultant Microbiologist, Belfast Health and Social Care Trust

Dr John O’Donohue, Consultant Physician and Gastroenterologist, Lewisham Healthcare NHS Trust

Dr Ewan Olson, Consultant Microbiologist, NHS Lothian

Dr Tamsin Oswald, Consultant Microbiologist, Northumbria Healthcare NHS Foundation Trust

Elizabeth Ozogolu, Senior Prescribing Advisor, City and Hackney Clinical Commissioning Group

Sarah Partridge, Antimicrobial Pharmacist, Nottingham University Hospitals NHS Trust

Dr Terry Riordan, Consultant Medical Microbiologist, Royal Devon and Exeter Healthcare NHS Trust

Dr Andrew Stacey, Consultant Microbiologist, Royal Berkshire NHS Foundation Trust

Dr Rebecca Tilley, Consultant Microbiologist (Antibiotic Lead), West Suffolk NHS Foundation Trust

Jane Usher, Biomedical Head of Serology/Virology, Public Health England

Dr Chloe Walsh, Microbiology Registrar, Leeds Teaching Hospitals NHS Trust

Rob Wise, Medicines Management Pharmacist, NHS Bassetlaw Clinical Commissioning Group

Primary Care Clinicians from Concord Medical Centre, Bristol

Primary Care Clinicians from Hanham Health Centre, Bristol

Members of the Advisory Committee on Antimicrobial Resistance and Healthcare Associated Infection (ARHAI)

Members of the British Infection Association (BIA)

Members of the British Society for Antimicrobial Chemotherapy (BSAC)

Members of the British Society of Gastroenterology (BSG)

Members of the Public Health England (PHE) Standards Unit

Members of the Royal College of General Practitioners (RCGP)

Members of the Royal College of Nursing (RCN)
Any conflicts of interest have been declared prior to the development and dissemination of this guidance.

Abbreviations



13C = 13Carbon

BD = Twice daily

CI = Confidence interval

CLAR = Clarithromycin

CYP2C19 = Cytochrome P450 2C19

DU = Duodenal ulcer

ECP = Enhanced compliance programme

ELISA = Enzyme-linked immunosorbent assay

g = Gram

GORD = Gastro-oesophageal reflux disease

GU = Gastric ulcer

gyrA = DNA gyrase subunit A

H2A = Histamine H2-receptor antagonist

HP = Helicobacter pylori

HTA = Health technology assessment

IgA = Immunoglobulin A

IgG = Immunoglobulin G

IgM = Immunoglobulin M

ITT = Intention to treat

LR+ = Positive likelihood ratio

LR- = Negative likelihood ratio

LRs = Likelihood ratios

MALToma = Mucosa-associated lymphoid tissue lymphoma

MIC = Minimum inhibitory concentration

mg = Milligram

MZ = Metronidazole

NPV = Negative predictive value

NSAID = Non-steroidal anti-inflammatory drug

pH = Potential of hydrogen

PPI = Proton pump inhibitor

QALYs = Quality adjusted life years

QDS = Four times daily

RR = Relative risk

SAT = Stool antigen test

UBT = Urea breath test

UHD = Ulcer healing drug


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