Pathogenesis Anaerobic cocci are opportunistic pathogens that cause a multitude of infections. They are part of the normal microbial flora of a healthy individual, but they can and do cause infections involving traumatized tissue or infections in the compromised host. They are isolated most often from a wide variety of polymicrobic infections (usually along with Bacteroides sp. or with facultative organisms or both), indicating a synergistic role in these infections. Approximately 10–15% of all isolates of anaerobic cocci come from pure culture infections, thus indicating that these organisms can be significant pathogens rather than innocuous commensals. In one series of 20 patients with anaerobic bacteremia, Peptostreptococcus species accounted for 21% of the 29 anaerobic isolates. The anaerobic cocci represent 25–30% of all anaerobic clinical isolates. Among anaerobes, they are second only to the gram-negative anaerobic bacilli in frequency of isolation from clinical specimens. The anaerobic cocci have received relatively little attention from microbiologists and clinicians. It is not known if anaerobic cocci produce toxins, capsules, or have other pathogenic attributes.
Patogenez Anaerob kokklar ko'plab infektsiyalarni keltirib chiqaradigan opportunistik patogenlardir. Ular sog'lom odamning normal mikrobial florasining bir qismidir, ammo ular shikastlangan to'qimalarni o'z ichiga olgan infektsiyalarni yoki buzilgan xostdagi infektsiyalarni keltirib chiqarishi mumkin va qiladi. Ular ko'pincha turli xil polimikrob infektsiyalardan (odatda Bacteroides sp. yoki fakultativ organizmlar yoki ikkalasi bilan birga) ajratiladi, bu bu infektsiyalarda sinergik rolni ko'rsatadi. Anaerob kokklarning barcha izolatlarining taxminan 10-15% sof kulturali infektsiyalardan kelib chiqadi, bu shuni ko'rsatadiki, bu organizmlar zararsiz kokklar emas, balki muhim patogenlar bo'lishi mumkin. Anaerob bakteriemiya bilan og'rigan 20 bemorning bir seriyasida, Peptostreptokokkturlari 29 ta anaerob izolatning 21% ni tashkil qiladi. Anaerob kokklar barcha anaerob klinik izolatlarning 25-30% ni tashkil qiladi. Anaeroblar orasida ular klinik namunalardan ajratib olish chastotasi bo'yicha gram-manfiy anaerob tayoqchalardan keyin ikkinchi o'rinda turadi. Anaerob kokklar mikrobiologlar va klinisyenlar tomonidan nisbatan kam e'tiborga olingan. Anaerob kokklar toksinlar, kapsulalar ishlab chiqaradimi yoki boshqa patogen atributlarga egami, noma'lum.
Host Defenses P magnus infection (in pure culture) of hip prostheses has produced a serum antibody response; however, in most cases, specific immune responses to anaerobic cocci have not been investigated.
Xost mudofaa son protezlarining P magnus infektsiyasi (sof madaniyatda) sarum antikor javobini keltirib chiqardi; biroq, aksariyat hollarda anaerob kokklarga xos immun javoblar tekshirilmagan.
