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Generalised agitation
Give a stat dose of midazolam 5mg subcutaneously. Repeat a 5mg dose after 15 minutes if necessary. After another 15 minutes give 10mg, if there was no or only a partial response to the initial two injections. A subcutaneous infusion via a syringe driver will need to be set up within the next two hours to ensure control is maintained, as midazolam has a very short half-life. Dose range will be between 20 –60mg over a 24-hour period. Ensure an adequate prn dose of midazolam 5-10mg is prescribed and available for use.
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