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Poster presentation 
308 
ON THE ANTIOXIDANT PROPERTIES OF CAPER BUDS 
EXTRACT 
 
D.A. Narbutaeva, A.M. Karakulova, Yu.R. Mirzaev, R.A. Botirov,
A.Z. Sadikov, Sh.Sh. Sagdullayev 
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail], 
phone: [phone]
 
The prickly caper plant has been known as a medicinal remedy since the times of 
ancient Greece and Rome. In the last decade, there has been an increased interest in the 
medicinal properties of preparations of this plant due to the presence of polyphenols, 
polysaccharides, alkaloids, lipids, etc. According to the literature, polyphenols and 
polysaccharides have an antioxidant effect. Antioxidants can be used in the treatment of 
neurodegenerative diseases, including Alzheimer's disease. Several extracts were 
isolated from capers collected in the Tashkent region, including from the buds of 
capers, whose studies revealed an increase in motor and research activity according to 
two tests. The composition of the extract of caper buds revealed about 30% of 
polysaccharides with known antioxidant or anti-radical properties. The prospects of 
substances with antioxidant activity in the treatment of Alzheimer's disease are 
indicated in literature. 
The purpose of the study is the identification of antioxidant properties of caper buds 
extract in order to assess its prospects as a potential therapeutic agent for 
neurodegenerative diseases.
The extract of caper buds was subjected to pharmacological research in comparison 
with vitamin E. The antioxidant activity of the studied substances was determined by 
their effect on the intensity of lipid peroxidation processes, which was assessed by the 
accumulation of malondialdehyde (MDA) in vitro experiments.
 
The content of malonic dialdehyde in 
in vitro
experiments was determined by a color 
reaction with thiobarbituric acid. The antioxidant properties of the compounds were 
evaluated on the accumulation of malondialdehyde under conditions of iron-induced as 
corbata-dependent POL, which was induced by 10 microns of FeSO
4
in the presence of 
200 microns of ascorbate in a medium containing 145 mM KCl, 25 mM tris HCl, pH 
7.4. All the studied samples were previously dissolved in 70% ethyl alcohol and 
examined at a dose of 1 *10
-5
mg/ml. As a comparison drug, an oil solution of 
pharmacy vitamin E (10%) in a concentration of 1 * 10
-5
mg/ml and or the extract of 
caper buds in the same concentration were used. Statistical processing was performed 
using the Student's t-test in the program Statistica version 6. Statsoft, Inc. (2001). 
The obtained data showed that when the incubation medium was introduced at a 
concentration of 10
-5
g/ml of the studied drugs, it contributed to a more pronounced 
inhibition of the processes of a peroxidation of liver lipids 
in vitro
and at the same time 
there was a more pronounced decrease in the formation of MDA, caper buds extract by 
51.0% (p<0.05), and vitamin E - 81.0% (p<0.001). 
Thus, the study showed the extract of caper buds has a significantly pronounced 
antioxidant effect for 37% less than those of vitamin E. Based on these data, it can be 
assumed that the extract of caper buds can be used as a promising tool in the complex 
treatment of neurodegenerative.

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Poster presentation 
309