Microsoft Word search phase 3 Title Page Amendment

Table 5-1. Anticipated Sample Size and Characteristics:  SEARCH Cohort Study (2002 - 2006, 2008) 
 SC 
OH 
CO 
CA 
WA 
All 
Type 
Race/Ethnicity 
80% 90%  80% 90%  80%  90% 80% 90% 80% 90% 80% 90% 
Type 1 
 
 
 
 
 
 
 
 
 
 
 
 
     NHW 
405 
456 
386 
434 
711 
800 
98 
110 
410 
461 
2010  2261 
     Other 
175 
197 
58 
65 
188 
211 
185 
209 
94 
106 
700 
788 
Type 2 
 
 
 
 
 
 
 
 
 
 
 
 
     NHW 
38 
42 
30 
34 
16 
17 
7 
8 
16 
18 
107 
119 
     Other 
106 
120 
42 
47 
79 
95 
83 
97 
18 
23 
328 
382 
ALL 
724 815  516 580  994 1123 373 424 538 608 3145 
3550 
 
While we considered including the 2001 prevalent cases for whom we also have baseline 
visit data, their dates of diagnosis ranged from 1982-2001.  Because of the secular 
changes in treatment regimens and clinical outcomes that have been observed in other 
studies, we determined it best to focus on a contemporary cohort with reasonable 
numbers of youth in each of the diagnosis years included, both for interpretability of 
findings from the proposed effort, and for potential future, continued follow-up. 

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Section 5B - Data Collection (Phase 3 - 1/2011, rev. 8/2011) 
Section 5B - Page 2 
 Cohort 
Study
 
5.1.2.
 
Retention Strategies 
We will continue to employ traditional, proven, cohort retention strategies including: 
birthday cards, study newsletters, updating contact information annually, utilizing 
internet-based search systems to locate individuals lost to follow-up, using cell-phone 
text messaging and e-mail, offering flexible study date appointments including home 
visits, offering assistance with transportation, mailing pre-visit instructions, a reminder 
call prior to the visit, acknowledgement of participation, and participant remunerations 
that are appropriate for the length and the respondent burden of the proposed study visit.  
Investigators and study personnel will also continue to solicit the support of diabetes 
providers to encourage on-going study participation.  Communications with providers 
include letters, e-mail messages, telephone calls, newsletters, individual discussions, and 
group presentations of study goals and preliminary results. 
We recently sought expert advice on marketing the study to youth and families affected 
by diabetes from the American Diabetes Association (ADA).  Their three major 
recommendations were 1) to update the SEARCH public website to make it more 
appealing to youth and families, 2) to utilize social networking, such as Facebook and 
MySpace to communicate with parents and participants, and 3) focus on positive 
messages about the study.  Pilot work on social networking strategies is currently 
planned.  During the planning of SEARCH 3, we conducted a survey of a sample of 
individuals (n=30) who previously were non-responders to SEARCH visits.  The most 
common barriers to participation were multiple demands of life and for youth 
specifically, not wanting to spend more time with diabetes-related activities.  The most 
common reasons for potential future participation were a desire to help others, to 
participate in finding a cure for diabetes, and to increase our understanding of diabetes.  
New strategies will be informed by these findings.  We have also increased monetary 
remuneration from $80 in the SEARCH 2 follow-up visit to $120 for participation in the 
SEARCH 3 Cohort Study research visit.  SEARCH will develop online forms to 
complete questionnaires for the study to enhance study participation and reduce