N. Barbarich-Marsteller. Columbia Univ.
Col. of P&S.
3:45
Novel treatments for bulimia and BED implicated by
animal models of binge-eating.
M. Boggiano. Univ. of
Alabama at Birmingham Col. of Arts and Sci.
4:15
Gene-environment interactions and epigenetic effects
in anorexia and bulimia nervosa.
H. Steiger. Douglas
Univ. Inst. and McGill Univ.
4:45
A psychogenetic perspective on binge eating disorder.
C. Davis. York Univ., Canada.
409. ASSESSING POSTGANGLIONIC SYMPATHETIC
NEURONAL DISCHARGE PATTERNS:
IMPLICATIONS FOR UNDERSTANDING
ABERRANT SYMPATHETIC OUTFLOW
Featured Topic
(Sponsored by: APS Neural Control and Autonomic
Regulation Section)
t
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am
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hoemaKer
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nuepFer
Blood Pressure Regulation
Central Control of Homeostasis
8:00
New advances in assessing multi-unit sympathetic
neural recruitment.
C. Steinback. Univ. of Calgary,
Canada.
8:20 Is an aberrant sympathetic nerve firing pattern
associated with markers of increased cardiovascular
risk?
E. Lambert. Baker IDI Heart and Diabetes Inst.,
Melbourne.
8:45
A case for a standardized method for the normalization
of muscle sympathetic nerve activity amplitude.
D.W.
White, V.L. Kay, G. Moralez, W.L. Eubank and P.B.
Raven. Univ. of North Texas Hlth. Sci. Ctr. at Fort
Worth.
(1117.1)
PHARMACOLOGY/PHYSIOLOGY
TUESDAY
115
T
U
E
9:00
Augmented response of renal sympathetic nerve
single units to chemoreceptor stimuli in rabbits with
angiotensin-induced hypertension.
G.A. Head, S.L.
Burke and E.V. Lukoshkova. Baker IDI Heart and
Diabetes Inst., Melbourne and Natl. Cardiol. Res. Ctr.,
Moscow.
(1117.2)
9:15 Sympathetic vascular transduction following
spontaneous MSNA bursts is augmented in young
black men.
D.P. Credeur, S.W. Holwerda, S.T.
Fairfax, D.M. Keller and P.J. Fadel. Univ. of Missouri-
Columbia and Univ. of Texas at Arlington.
(1117.3)
9:30
Sympathetic and cardiovagal baroreflex sensitivity in
humans: comparison of Valsalva’s maneuver and
spontaneous methodologies.
H. Yang and J.R.
Carter. Michigan Technol. Univ. (1117.4)
9:45 Sympathetic nerve activity and systemic arterial
pressure during obstructive sleep apnea in conscious
rats.
C. Sukeguchi and K. Miki. Nara Women’s Univ.,
Japan.
(1117.5)
410. COMMUNICATING SCIENCE TO NON-
SCIENTISTS: KEYS TO FUNDING AND
VISIBILITY
Symposium
(Sponsored by: APS Careers in Physiology Committee)
t
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am
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onvention
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C
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: s. D. C
oaxum
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l. r. l
eon
Career Development
8:00
New and old techniques to build your network,
effectively tell your story, and obtain grant funding.
J.
R. Raymond. Med. Col. of Wisconsin.
8:30
Have a point!!! And a few other suggestions for
successfully talking science with non-scientists.
B.
Murray. Sport Science Insights, LLC.
9:00
The bridge between industry and academic research: a
win-win situation.
E. Motley-Johnson. Meharry Med.
Col.
411. HANS USSING AWARD
Featured Topic
(Sponsored by: APS Epithelial Transport Group)
t
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am
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-s
oler
Transporters and Ion Channels
8:00
Hans Ussing Lecture. An unexpected journey: conceptual
evolution of mechanoregulated ion transport in the
distal nephron.
L. Satlin. Mount Sinai Hosp., NY.
9:00
Acetylation modulates ENaC degradation.
P.L. Butler
and P.M. Snyder. Univ. of Iowa. (1148.6)
9:15
Mice lacking protein kinase C
a show enhanced
membrane localization and activity of the epithelial
sodium channel in the renal cortical collecting duct.
H-F. Bao, Q. Yue, T.L. Thai, J.D. Klein, J.M. Sands
and D.C. Eaton. Emory Univ. (1148.3)
9:30
Evidence for the existence of calcium signaling domains
in a renal cortical collecting duct cell line.
T.L. Thai,
H-F. Bao, B. Liu, H. Ma and D.C. Eaton. Emory Univ.
(1148.15)
9:45
AQP2 poly-phosphorylation and water permeability in
inner medullary collecting duct.
C.A. Miranda, J.W.
Lee, C.L. Chou and M.A. Knepper. NHLBI, NIH.
(1148.18)
412. INTEGRATIVE PHYSIOLOGY OF HORMONAL
AND NEURAL EFFECTS FOLLOWING GASTRIC
BYPASS SURGERY
Symposium
(Sponsored by: APS Central Nervous System Section)
t
ue
. 8:00
am
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oston
C
onvention
& e
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enter
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C
haired
: K. B
roWninG
anD
a. h
aJnal
Central Control of Homeostasis
Metabolic Diseases
8:00
Metabolic effects of Roux-en-Y gastric bypass surgery:
an overview.
L. M. Kaplan. Massachusetts Gen. Hosp.
8:30
Mechanism of glucose detection and response in the
gastrointestinal tract: implications for resolution of
dysglycemia after gastric bypass.
S. Munger. Univ. of
Maryland Sch. of Med., Baltimore.
9:00
Effects of gastric bypass surgery on responsiveness
of central vagal neurons to gastrointestinal
neuropeptides.
K. Browning. Penn State Col. of Med.
9:30
Effects of gastric bypass surgery on CNS insulin
sensitivity.
R. Sherwin. Yale Univ. Sch. of Med.
413. MATRIX METALLOPROTEINASES IN THE
CARDIOVASCULAR SYSTEM
Featured Topic
(Sponsored by: APS Cardiovascular Section)
t
ue
. 8:00
am
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onvention
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Chulz
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p. K. m
ishra
Inflammation and Immune Responses
Translational Physiology
8:00
Role of MMPs in aberrant fibrotic remodeling: regulation
of fibrocyte migration and homing.
A. Pardo. UNAM,
Mexico City.
8:30
Role of a truncated intracellular isoform of matrix
metalloproteinase-2 in cardiac inflammation and
failure.
D. Lovett. San Francisco VA Med. Ctr.
9:00
Both collagen and elastin matrices are remodeled in
the failing ovine atria – a role for elastin-degrading
enzymes in atrial structural remodeling.
M.A. Horn,
H.K. Graham, S.J. Borland, J.D. Clarke, K.M. Dibb
and A.W. Trafford. Univ. of Manchester. (1129.7)
9:15
Endurance exercise training attenuates fibrosis and
collagen cross-linking in myocardium of aged
F344BNF1 rats.
K.J. Wright, A. Betik, M. Thomas,
R. Hepple and D. Belke. McGill Univ., Victoria Univ.,
Australia, McMaster Univ. and Univ. of Calgary,
Canada.
(1129.5)
TUESDAY PHYSIOLOGY
116
9:30
Activation of proteases and changes in Na
+
-K
+
ATPase
subunits in hearts subjected to ischemia-reperfusion.
A.L. Müller, D.H. Freed and N.S. Dhalla. Univ. of
Manitoba.
(1129.8)
9:45
Doxycycline attenuates cardiac injury and improves
cardiac function with inhibition of myocardial matrix
metalloproteinase-2 in a swine model of hypoxia-
reoxygenation.
J.R. LaBossiere, J-S. Pelletier, M.
Ali, D. Bigam, R. Schulz and P-Y. Cheung. Univ. of
Alberta.
(1129.9)
414. METABOLIC DISEASE AND LIVER INJURY
Featured Topic
(Sponsored by: APS Gastrointestinal and Liver
Physiology Section)
t
ue
. 8:00
am
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oston
C
onvention
& e
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C
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C
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: B. h
aGenBuCh
Metabolic Diseases
8:00
START domain-mediated metabolic regulation in the
liver.
David Cohen. Brigham and Women’s Hosp.,
Harvard Med. Sch.
8:30
Steatosis response to curcumin in an obese mouse
model.
A. Nookala, T. Quinn, B. Herndon, A. Molteni,
L. Alba, J. Nachnani and D. Bulchandani. Univ. of
Missouri-Kansas City Sch. of Med. and Sumner Med.
Gp., Gallatin, TN.
(1155.1)
8:45
Metformin, aerobic exercise, and the combination in the
treatment of type 2 diabetes and NAFLD in OLETF
rats.
M.A. Linden, G.M. Meers, J.A. Fletcher, S.
Siddique, M.H. Laughlin, F.W. Booth, J.A. Ibdah,
J.P. Thyfault and R.S. Rector. Univ. of Missouri-
Columbia and Harry S. Truman Mem. Veterans Med.
Ctr.
(1155.2)
9:00
The role of
b1 adrenergic receptor in non-alcoholic
fat liver disease development.
G.W. Fernandes,
C.P. Marcelino, P.C. Brum, M. Passarelli, B.M.L.
Bocco and M.O. Ribeiro. Fed. Univ. of São Paulo,
Presbyterian Univ. Mackenzie, São Paulo and Sch. of
Phys. Educ. and Sport and Fac. of Med. Sci., Univ. of
São Paulo.
(1155.4)
9:15
Increased corticosterone levels contribute to glucose
intolerance induced by the absence of melatonin.
S.C. Rodrigues, L. Pantaleão, C. Lellis-Santos,
K. Veras, F. Amaral, G. Anhê and S. Bordin. Univ.
of São Paulo and Fac. of Med. Sci., State Univ. of
Campinas, Brazil.
(1161.1)
9:30
Roux-en-Y gastric bypass surgery prevents diet-induced
hepatic steatosis and endoplasmic reticulum stress in
the liver of obese rats.
J.D. Mosinski, M. Pagadala,
H. Huang, O. Dan, H. Shimizu, E. Batayyah, P.R.
Schauer, S.A. Brethauer and J.P. Kirwan. Cleveland
Clin. Fndn.
(1161.8)
9:45
Hepatic steatosis and severe coagulopathy precede
premature death in GCN2 null mice treated with
asparaginase.
G.J. Wilson, P. She, E.T. Mirek, R.C.
Wek and T.G. Anthony. Rutgers Univ. and Indiana
Univ. Sch. of Med.
(1161.6)
415. MICROVASCULAR RESPONSES AND
THERMOREGULATORY CONTROL IN NORMAL
AND CLINICAL POPULATIONS
Featured Topic
(Sponsored by: APS Environmental and Exercise
Physiology Section)
t
ue
. 8:00
am
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C
onvention
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xhiBition
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C
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: W. K
enney
8:00
Mechanisms of cutaneous microvascular dysfunction
in essential hypertension: insights and questions.
L.
Alexander. Penn State.
8:30
Microvascular function is reduced in normotensive salt-
sensitive individuals independent of dietary sodium
intake.
J.J. DuPont, J.L. Greaney, E.M. Matthews,
S.L. Lennon-Edwards, W.B. Farquhar and D.G.
Edwards. Univ. of Delaware. (1133.9)
8:45
Endothelium-dependent cutaneous vasodilation in young
smokers: role of endothelial-derived hyperpolarizing
factors.
N. Fujii, V.E. Brunt, M.A. Francisco and C.T.
Minson. Univ. of Oregon. (1133.17)
9:00 Acute oral sapropterin (Kuvan®) augments NO-
dependent reflex vasodilation in aged human skin.
A.E. Stanhewicz, L.M. Alexander and W.L. Kenney.
Penn State.
(1133.12)
9:15
Whole-body sweat sensitivity in burn survivors following
heat acclimation.
Z.J. Schlader, R.A.I. Lucas, P.
James, M.S. Ganio and C.G. Crandall. Presbyterian
Hosp. of Dallas, Cardiff Metro. Univ., U.K. and Univ. of
Arkansas.
(1133.6)
9:30
Thermoregulatory control of skin blood flow and
sweating in multiple sclerosis.
S. Davis. Southern
Methodist Univ.
416. NEUROENDOCRINE REGULATION OF THE
MAMMALIAN REPRODUCTIVE AXIS
Symposium
(Sponsored by: The Physiological Society)
t
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am
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oston
C
onvention
& e
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C
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, 210a
C
haired
: W. C
olleDGe
8:00
The genetics of hypogonadotropic hypogonadism.
S.
Seminara. Massachusetts Gen. Hosp.
8:30
Genetic dissection of puberty using transgenic mice.
U.
Boehm. Univ. of Hamburg.
9:00
Electrophysiological profile of Kiss1 neurons.
M. Kelly.
Oregon Hlth. & Sci. Univ.
9:30
Neuronal circuits in the hypothalamus-controlling GnRH
release.
S-H. Yeo. Univ. of Otago.
PHYSIOLOGY TUESDAY
117
T
U
E
417. NOVEL INTERVENTIONS FOR TREATING
OBESITY AND TYPE 2 DIABETES
Featured Topic
(Sponsored by: APS Endocrinology and Metabolism
Section)
t
ue
. 8:00
am
—B
oston
C
onvention
& e
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C
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C
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: t. t. r
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J. t. B
rozniCK
Metabolic Diseases
8:00
MnTBAP: an antioxidant that reverses diet-induced
adiposity and insulin resistance.
T. H. Reynolds.
Skidmore Col.
8:30
Resetting the clock: hitting ROR
a to treat metabolic
syndrome.
J. T. Brozinick. Eli Lilly and Co.
9:00
Chronic carbon monoxide treatment attenuates the
development of obesity and remodels adipocytes in
mice fed a high fat diet.
P.A. Hosick, A.A. Al Amoudi,
M.V. Storm, M.U. Gousset, B.E. Pruett, W. Gray III,
J. Stout and D.E. Stec. Univ. of Mississippi Med. Ctr.
(1154.4)
9:15
Activation of CaMKK
a stimulates skeletal muscle
glucose uptake in insulin-resistant mice.
C.A.
Witczak, J.M. Hinkley, J.L. Ferey, C.A.S. Smith,
L.A.A. Gilliam and J.J. Brault. East Carolina Univ.
Brody Sch. of Med.
(1154.16)
9:30
The role of skeletal muscle tribbles 3 on endoplasmic
reticulum stress- and high fat diet-induced insulin
resistance.
H-J. Koh, T. Toyoda, M.M. Jung, M-Y. Lee,
M.F. Hirshman and L.J. Goodyear. Joslin Diabetes
Ctr. Inc.
(1154.5)
9:45 TRPV1 in the paraventricular nucleus of the
hypothalamus is involved in the regulation of systemic
blood glucose levels.
A. Zsombok, K. Miyata,
J.D. O’Hare, T.L. Fourrier, A.M. Krantz and A.V.
Derbenev. Tulane Univ. (1154.13)
418. OXIDATIVE STRESS II
Featured Topic
(Sponsored by: APS Cell and Molecular Physiology
Section)
t
ue
. 8:00
am
—B
oston
C
onvention
& e
xhiBition
C
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, 206B
C
haired
: m. h
elms
anD
s. n
ieDerleChner
Hypoxia and Oxidative Stress
8:00
The physiology of oxidative stress and ion transport.
C.
A. Downs. Emory Univ. Sch. of Med.
8:30
Resolvins play a role in the resolution of acute lung injury.
R.R. Cox, Jr., O. Phillips, J. Fukumoto, I. Fukumoto,
P. Tamarapu Parthasarathy, V. Lagishetty, T. Luong,
N. Remsen, R. Lockey and N. Kolliputi. Univ. of
South Florida Morsani Col. of Med.
(1143.4)
8:45
Resveratrol blunts the positive effects of exercise training
in aged men; a double-blind, randomized, placebo-
controlled training study.
L. Gliemann, M. Nyberg,
R.S. Biensø, N. Iversen, J. Olesen, S.P. Mortensen,
J.F. Schmidt, H. Pilegaard and Y. Hellsten. Univ. of
Copenhagen and Rigshospitalet.
(1143.7)
9:00
Nitric oxide deficit elicits oxidative stress and augments
T-type calcium channel contribution to vascular tone.
C.E. Hill, I.Y. Kuo, A. Ellis, D.J. Chaston, H-S. Shin,
P.B. Hansen and L. Howitt. Australian Natl. Univ.,
Korea Inst. of Sci. and Technol. and Univ. of Southern
Denmark.
(1143.8)
9:15
Role of TRPC6 in high glucose-induced podocyte
apoptosis.
B-C. Liu, X. Song, L-L. Yang, D. Eaton
and H-P. Ma. Emory Univ. Sch. of Med. (1143.12)
9:30
Superoxide and hydrogen peroxide stimulate renin
release from juxtaglomerular cells.
M. Mendez. Henry
Ford Hosp..
(1143.13)
9:45 N-acetylcysteine administration modulates NADPH
oxidase in skeletal muscle of rats with heart failure.
P.F. Martinez, D.C. Fernandes, C. Bonomo, M.D.M.
Cezar, S.A. Oliveira, Jr., L.A.M. Zornoff, K. Okoshi,
F.R. Laurindo and M.P. Okoshi. UNESP, Botucatu,
InCor, São Paulo and UFMS, Campo Grande, Brazil.
(1143.9)
419. RECENT ADVANCES IN RENAL
PATHOPHYSIOLOGY
Featured Topic
(Sponsored by: APS Renal Section)
t
ue
. 8:00
am
—B
oston
C
onvention
& e
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C
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C
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: D. W
einer
anD
l. C. e
vans
8:00
Evaluation of the role of the NAD(P)H oxidase subunit
p67
phox
in the regulation of medullary blood flow in Dahl
S rats.
L.C. Evans, R. Ryan, T. Kurth, M. Skelton and
A. Cowley, Jr. Med. Col. of Wisconsin. (704.4)
8:15
Renal collecting duct cell-specific mVps34 deletion
decreases nephron number and increases nephron
size.
J-K. Chen, B. Hu and J. Chen. Georgia Regents
Univ. and Vanderbilt Univ. Sch. of Med.
(705.11)
8:30
Connecting tubule glomerular feedback in Dahl salt-
sensitive and spontaneously hypertensive rats.
M.A.
D’Ambrosio, H. Wang, J.L. Garvin, Y. Ren and O.A.
Carretero. Henry Ford Hosp. (1110.24)
8:45
Nrf2 mediates the antioxidant effect of DJ-1 in the
kidney.
S. Cuevas, Y. Yang, L. Asico, C.S. Escano,
I. Armando and P.A. Jose. Univ. of Maryland Sch. of
Med.
(704.10)
9:00 Protein carbamylation is a physiological post-
translational modification in the renal inner medulla.
J.S. Claxton, G. Liu, P.C. Sandoval, C-L. Chou and
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