157
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C193
563.4
Targeting melanocortin-4 receptor agonists to
the endoplasmic reticulum as a potential approach to obesity
therapy.
B.M. Molden, S. Granell and G. Baldini. Univ. of
Arkansas for Med. Sci.
C194
563.5
The role of stearoyl-CoA desaturase-3 in lipid
metabolism.
L. Bond, M. Strable, L. Ade and J. Ntambi. Univ.
of Wisconsin-Madison.
564. FRONTIERS IN OBESITY RESEARCH
Poster
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C195
564.1
Oral administration of cholic acid modulates
the gut microbiota and epithelial proliferation. S. Ishizuka, M.
Takatsuki, M. Shiwaku, M. Hagio, R. Yoshitsugu, K. Kikuchi, N.
Fujii, G-H. Joe, H. Shimizu, H. Hara, S. Fukiya and A. Yokota.
Hokkaido Univ., Japan.
C196
564.2
Can BPA leaching from baby bottles and
take-out containers contribute to the obesity epidemic?
A.
Tarasenko and B. Sampoli Benitez. Marymount Manhattan
Col.
C197
564.3
An increase in bile acids in enterohepatic
circulation within a physiological range induces some pathologic
features in metabolic syndrome.
R. Yoshitsugu, K. Kikuchi, M.
Hagio, H. Shimizu, H. Hara and S. Ishizuka. Hokkaido Univ.,
Japan.
C198
564.4
Deficiency of the DNA glycosylase OGG1
alters muscle mitochondrial dynamics and predisposes mice to
diet-induced metabolic disease.
H. Sampath, V. Vartanian and
R.S. Lloyd. Oregon Hlth. & Sci. Univ.
565. OBESITY AND THE METABOLIC SYNDROME
Poster
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Presentation time: 1:05
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C199
565.1
Obesity induced fibrinogen formation and its
effect on adipocyte inflammation and glucose uptake.
C.M.
Paton. Texas Tech Univ.
C200
565.2
Chickens genetically selected for high or low
juvenile body weight display differences in glucose tolerance
and insulin sensitivity.
L. Sumners, X. Zhao, W. Zhang, C.
Honaker, P. Siegel and E. Gilbert. Virginia Tech and Sichuan
Agr. Univ., China.
C201
565.3
Palmitate-induced impairment of
melanocortin-4 receptor.
F.K. McDaniel and G. Baldini. Univ.
of Arkansas for Med. Sci.
C202
565.4
Profile of the liver sinusoidal endothelial cell
in non-alcohol fatty liver.
E.N. Harris and S. Gopalakrishnan.
Univ. of Nebraska-Lincoln.
C203
565.5
Redox state as a master regulator of liver
function.
L. Nocito, E.J. Yoo and B.E. Corkey. Boston Univ.
Sch. of Med.
C204
565.6
Decreased autophagic flux as a mechanism
of glucose- and fatty acid-induced dysfunction in human aortic
endothelial cells.
K.A. Weikel, Y. Ido and N. Ruderman. Boston
Med. Ctr. and Boston Univ.
566. CONTROLLING CELLULAR COMMUNICATION
Poster
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. 7:30
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Presentation time: 1:05
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pm
C205
566.1
A small optogenetic tool for spatiotemporal
control of intracellular cAMP.
C.P. O’Banion and D.S.
Lawrence. Univ. of North Carolina at Chapel Hill.
C206
566.2
Increased oxygen enhances bone degradation
and promotes bone regeneration after digit amputation in
mice.
A.J. Cammack, P. Mandava, K. Van Meter, K. Muneoka
and M. Sammarco. Tulane Univ. and LSU Hlth. Sci. Ctr., New
Orleans.
567. CHEMICAL PERSPECTIVES IN NEUROBIOLOGY
Poster
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un
. 7:30
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Presentation time: 1:05
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C208
567.1
Evaluation of a Parkinson’s disease model in
medaka fish.
S.J. Ferng, D.E. Gonzalez, M.N. Nguyen, S.J.
Sherman, T. Falk and H.L. Rilo. Univ. of Arizona.
C209
567.2
Hippocampal place field activity in rats trained
to walk forward and backwards.
J. Ferng, S.N. Burke and C.A.
Barnes. Univ. of Arizona.
C210
567.3
Effects of 4-phenylbutyric acid on the process
and development of cerebrum injury in diabetic rats: regulation
of endoplasmic reticulum stress inflammatory response.
Z.
Wang, H. Zhang, H. Shi and J. Xiao. Wenzhou Med. Col.,
China.
C211
567.4
Neuroprotection of estrogen of hypothalamic
cell line due to hypoglycemic injury.
S. Chakraborty. New York
City Col. of Technol., CUNY.
568. CHEMICAL PROBES AND THEIR USE IN
IDENTIFYING NEW THERAPEUTIC TARGETS
Poster
s
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. 7:30
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Presentation time: 1:05
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C212
568.1
Optimizing the binding affinity of a peptoid
antagonist of VEGFR2 through backbone modifications.
J.A.
Cox, G. Rubin, A. Aditya and T. Kodadek. Univ. of California,
Berkeley and The Scripps Res. Inst.
C213
568.2
Ultra-sensitive detection of breast cancer
stem cell specific surface marker CD44 based on a polyvalent
directed peptide polymer.
M-Y. Yoon, J-H. Cho and S-C. Lee.
Hanyang Univ., South Korea.
SUNDAY BIOCHEMISTRY
158
569. REGULATORY NETWORKS
Poster
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Presentation time: 1:05
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-2:35
pm
C214
569.1
Correlation between genotypes and behavioral
phenotypes in a mouse model simulating aspects of human
post-traumatic stress disorder.
S. Srinivasan, B. Sowe,
S-A. Miller, S. Muhie, N. Chakraborty, R. Hammamieh, J.
Meyerhoff and M. Jett. U.S. Army Ctr. for Envrn. Hlth. Res.,
Fort Detrick, MD.
570. SUBSYSTEMS AND SIMULATION
Poster
s
un
. 7:30
am
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Presentation time: 1:05
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-2:35
pm
C215
570.1
Pectinase hyperproduction in fungi isolates.
U.A. Okafor, A.O. Ebuehi, V.I. Okochi, A. Adekunle and O.A.
Magbagbeola. Albany State Univ. and Univ. of Lagos, Nigeria.
571. TARGET IDENTIFCATION AND PATHWAY
MINING
Poster
s
un
. 7:30
am
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Presentation time: 1:05
pm
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pm
C216
571.1
Ultra high-throughput screening uncovers
new activities in phosphatases of the haloalkanoic acid
dehalogenase superfamily.
J.D. Farelli, H. Huang, C. Liu, C.
Pandya, N.F. Al Obaidi, B.S. Hillerich, J.D. Love, S.C. Almo,
D. Dunaway-Mariano and K.N. Allen. Boston Univ., Univ. of
New Mexico and Albert Einstein Col. of Med.
572. COMPUTATIONAL APPROACHES IN SYSTEMS
BIOLOGY
Poster
s
un
. 7:30
am
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Presentation time: 1:05
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C217
572.1
Computerized simulation and integration of
biosystems based on the mass-action law algorithms.
T-C.
Chou. Mem. Sloan-Kettering Cancer Ctr.
C218
572.2
The use of pyrosequencing to analyze microbial
populations in poultry management to minimize downstream
food contamination.
V.P. Guttala, J. Bray, E.G. Medrano and
B.A. Clack. Stephen F. Austin State Univ. and USDA, College
Station, TX.
573. PROTEIN PROFILING IN NORMAL AND
DISEASE STATES
Poster
s
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. 7:30
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Presentation time: 1:05
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C219
573.1
An exploration of functional domains in the
zebrafish ortholog of human Usher syndrome gene USH2A.
R.R. Drake, J. Phillips and M. Westerfield. Univ. of Minnesota,
Minneapolis and Univ. of Oregon.
C220
573.2
Comparative proteomic analysis of an isogenic
pair of lung normal and lung cancer cell line.
M.M. Alam, J.
Hooda, D. Cadinu, R.M. Henke, X. Ma and L. Zhang. Univ. of
Texas at Dallas.
C221
573.3
Inflammatory markers associated with
osteoarthritis after destabilization surgery in mice with and
without receptor for advanced glycation end products.
D.J.
Larkin, J.Z. Kartchner, W.R. Hollis, A.S. Doxey, G.G.
Jackson, S.K. Wilhelm, D.M. Peterson, E.M. Chavez, J.L.
Rees, S.S. Haynie, C.S. Draper, P.R. Reynolds and D.L.
Kooyman. Brigham Young Univ.
C222
573.4
A targeted proteomics approach for profiling
nuclear proteins in insulin-resistant adipocytes.
A. Ota, K.
Kovary, R. Ahrends, W-J. Shen, F.B. Kraemer and M.N.
Teruel. Stanford Univ.
C223
573.5
Apoptosis associated with osteoarthritis is
attenuated in mice lacking the receptor for advanced glycation
end products.
S.K. Wilhelm, D.J. Larkin, A.S. Doxey, J.Z.
Kartchner, J. Vanderuff, K. Anderson, C.S. Draper, E.
Chavez, P.R. Reynolds and D.L. Kooyman. Brigham Young
Univ.
C224
573.6
Differential protein expression profiles of
human lymph and plasma mapped by 2D-DIGE and 1D SDS-
PAGE coupled with nanoLC-ESI-MS/MS bottom-up proteomics.
C.C. Clement and L. Santambrogio. Albert Einstein Col. Med.
574. METHODS
Poster
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C225
574.1
3d o
2
imaging in the neuronal spheroids.
R.I.
Dmitriev, A.V. Zhdanov, Y.M. Nolan and D.B. Papkovsky.
Univ. Col. Cork, Ireland.
C226
574.2
Method for the preparation of gram quantities
of highly purified Bowman Birk inhibitor from glycine max.
B.M.
Tulk, M. Mekel, J. Wu and C. Schasteen. Solae LLC, St. Louis.
C227
574.3
Luciferin analogs for improved genetic
reporter assays.
Y. Kovic, J.C. Rosenberg, C.E. Behney,
T.L. Southworth, B.R. Branchini, C.C. Woodroofe, P.L.
Meisenheimer and D.H. Klaubert. Connecticut Col. and
Promega Biosci. Inc.
C228
574.4
Comparison of TaqMan and SYBR Green
qPCR methods for quantitative gene expression in plants.
H.
Cao and J.M. Shockey. USDA, New Orleans.
C229
574.5
Comparison of TaqMan and SYBR Green
qPCR methods for quantitative gene expression in animals.
H.
Cao, A-M. Roussel and R.A. Anderson. USDA, New Orleans,
Joseph Fourier Univ., Grenoble and USDA, Beltsville.
BIOCHEMISTRY SUNDAY
159
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C230
574.6
Binding site selection and cleavage activity of
zinc finger nucleases targeting Gaucher mutation.
S. Dahal, E.
Rowland, B. Oakes and M. Noyes. Univ. of New Orleans and
Princeton Univ.
C231
574.7
Determining the presence of arsenic in chicken
products using atomic absorption spectroscopy.
K.J. Mercer,
K.R. Bradley and W.L. Burns. Bellarmine Univ., KY.
C232
574.8
Optimizing environmental conditions and
image processing as a means for simplifying BRET imaging.
J.K. Finafrock and A.G. von Arnim. Westminster Col., PA and
Univ. of Tennessee, Knoxville.
C233
574.9
Development of photocrosslinkable class
I peptide-major histocompatibility complex monomers for
detecting antigen-specific T cells.
M.P. Rincon and J. Xie.
California State Univ., Los Angeles and Stanford Univ. Sch. of
Med.
C234
574.10 Reflections on the use of protease inhibitor
cocktails for preserving protein in tissue lysates.
C.S. Hoegler,
G. Murphy-Goldberg, L. Ponessi and C.F. Blando-Hoegler.
Mount Saint Mary Col., NY and Pace Univ.. NY.
C235
574.11 Withdrawn.
575. NANOTECHNOLOGY
Poster
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C236
575.1
Gold nanoparticles associated with neutral
red as potential drug delivery for photodynamic therapy.
N.T.
Santos, T.V. Verissimo, J.R. Silva, R.B. Azevedo, A.J. Gomes
and C.N. Lunardi. Univ. of Brasilia.
C237
575.2
Hydrogel modification for drug delivery.
C.R.
Souza, H.R. Oliveira, L.S. Biswaro, R.B. Azevedo and C.N.
Lunardi. Univ. of Brasilia.
C238
575.3
Production and characterization of polylactic
acid nanoparticles containing drugs applied in cancer therapy.
J.B.F. Conceição and A.J. Gomes. Univ. of Brasilia.
C239
575.4
Preparation and characterization of guar gum
microparticles loaded with cisplatin.
C.M. Ribeiro and A.J.
Gomes. Univ. of Brasília.
C240
575.5
Fluorescent nanoparticles based on
fluorescein.
A.P.V. Araujo and A.J. Gomes. Univ. of Brasilia.
C241
575.6
Amino-functionalized polystyrene
nanoparticles activate the NLRP3 inflammasome in human
macrophages.
O. Lunov, T. Syrovets, C. Loos, G.U. Nienhaus,
V. Mailänder, K. Landfester and T. Simmet. Ulm Univ.,
Karlsruhe Inst. of Technol. and Max Planck Inst. for Polymer
Res., Mainz, Germany.
C242
575.7
Amino-functionalized nanoparticles inhibit
mTOR and induce cell cycle arrest and apoptosis in leukemia
cells.
C. Loos, O. Lunov, T. Syrovets, G.U. Nienhaus, V.
Mailänder, K. Landfester and T. Simmet. Ulm Univ., Karlsruhe
Inst. of Technol. and Max Planck Inst. for Polymer Res., Mainz,
Germany.
C243
575.8
PLGA nanoparticles loaded with antitumoral
drug as a drug delivery system.
D.J.S. Dias, G.A. Joanitti,
L.P. Silva, C.N. Lunardi and A.J. Gomes. Univ. of Brasilia and
CENARGEN, Brazilia.
C244
575.9
Methacrylate polymer nanoparticle loaded
with ZnPc as a promising anticancer drug delivery system.
S.S.
Barros and A.J. Gomes. Univ. of Brasilia.
C245
575.10 Drug delivery system based on PLGA
nanoparticles containing tamoxifen as antitumor agent.
N.A.
Oliveira, J.R. Silva, R.B. Azevedo and A.J. Gomes. Univ. of
Brasilia.
C246
575.11 Cytotoxicity screening of a series of
semiconductor quantum dots for their potential biomedical
use.
E. Ermilov, W. Kuzyniak, O. Adegoke, K. Sekhosana, B.
Hoffmann, T. Nyokong, A.R. Pries and M. Höpfner. Charité -
Univ. Clin. Berlin and Rhodes Univ., South Africa.
C247
575.12 Impacts of silver nanoparticles on bacterial
multidrug efflux pump.
G. He, W. Zhang, H. Chen, S. Saliba,
C. Thorpe, E. Rogers and S. Hsie. Univ. of Massachusetts
Lowell and Natl. Ctr. of Toxicol. Res., Jefferson, AR.
C248
575.13 Synthesis, characterization and toxicological
evaluation of maltodextrin-capped cadmium sulfide
nanoparticles in human cell lines and chicken embryos.
A. Leon-Buitimea, P. Rodriguez-Fragoso, J.A. Reyes-
Esparza and L. Rodriguez-Fragoso. Fac. of Pharm., UAEM,
Cuernavaca and CINVESTAV, Mexico City.
576. NEW MOLECULAR AND CELLULAR IMAGING
AGENTS
Poster
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C249
576.1
Metabolic lysosomal enzyme probes.
J.J.
Naleway, F.K. Harlan, N. Longo, M. Pasquali and J.D. Stein.
Marker Gene Technols. Inc., Eugene, OR and Univ. of Utah
Sch. of Med.
C250
576.2
Phosphorescent nanoparticle based probes for
imaging and measurement of cellular oxygen.
A. Kondrashina,
R. Dmitriev, S. Borisov, I. Klimant, A. Zhdanov and D.
Papkovsky. University Col. Cork and Univ. of Technol. Graz,
Austria.
C251
576.3
Imaging promoter activity to monitor gene
expression using intracellular multiaptamer genetic tag
(IMAGEtag).
J. Ray, I. Shin, M. Zhao, M. Ilgu, V. Gupta, J.
Beasley, A. Agrawal, L. Peng, G. Kraus and M. Nilsen-
Hamilton. Iowa State Univ., Univ. of Arizona and The Scripps
Res. Inst., Jupiter, FL.
C252
576.4
Structure-based engineering of an infrared
fluorescent protein marker.
S.L. Puetz, J. Meraz, A. Varela,
B. Igova, A. Baker, A.E. Schirmer, E.A. Stojkovic and J.T.M.
Kennis. Northeastern Illinois Univ. and VU Univ. Amsterdam.
577. SMALL MOLECULE TOOLS FOR BIOLOGY
Poster
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C253
577.1
Antioxidants in your diet: a new method to
measure antioxidant effectiveness.
C. Bartow-McKenney, S.
Belli, F. Caruso and M. Rossi. Vassar Col.
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