Z. Yang and D. Golemi-Kotra. York Univ., Canada.
C44
769.3
DNA-binding studies of FOXO1 through site-
directed mutagenesis.
E. Blunt, M. Mottamal, C. Collins and
K. Johanson. Xavier Univ. of Louisiana.
BIOCHEMISTRY MONDAY
239
M
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C45
769.4
Triiodothyronine indirectly increases
amphiregulin gene expression levels via estrogen receptor
activation.
M.T. De Sibio, A.C. Luvizon, S.J. Conde, M.
Oliveira, R.M.C. Olimpio, F.C.F. Moretto, R.M.A. Luvizotto,
D. Fecchio and C.R. Nogueira. Fac. of Med., Univ. of São
Paulo, Botucatu.
C46
769.5
Identification of a novel transcription factor
impacting iron homeostasis.
K.L. Miller, C. Theisen, B. Cone,
J. Williams, D.P. Logsdon, F.C. Costa and R.A. White. Univ.
of Kansas Med. Ctr. and Kansas City Univ. of Med. and Biosci.,
MO.
C47
769.6
Role of HSF1 phopshorylation in heat shock
response.
M.A. Budzyñski, M. Puustien, J. Joutsen, J.
Anckar and L. Sistonen. Abo Akademi Univ., Finland and
Harvard Med. Sch.
C48
769.7
Characterization of a MarR homolog in Vibrio
vulnificus.
T.L. Lemon and A. Grove. LSU.
C49
769.8
The P-TEFb-dependent gene coding for IL-1
b
is more sensitive to cellular metabolism than that of the BRD4-
dependent TNF
a-coding gene. J. Adamik, G.M. Tannahill,
A-J.A. Su, L.A. O’Neill, D.L. Galson and P.E. Auron. Univ. of
Pittsburgh Sch. of Med., Duquesne Univ. and Sch. of Biochem.
and Immunol., Trinity Col. Dublin.
C50
769.9
Mediator affects Pol II recruitment and
nucleosome displacement at heat shock protein genes in
Saccharomyces cerevisiae.
Y. Moustafa and D.S. Gross. LSU
Hlth. Sci. Ctr., Shreveport.
C51
769.10 Role of HDAC1 complexes in gene regulation
at the nuclear lamina.
G. Bushman, B.C. Milon and D.I.
Nurminsky. Towson Univ. and Univ. of Maryland Baltimore.
770. CHROMATIN REMODELING DURING
TRANSCRIPTION
Poster
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C52
770.1
MeCP2’s role in chromatin structure and
stability.
C. Riedmann and Y. Fondufe-Mittendorf. Univ. of
Kentucky.
C53
770.2
NPM new interacting partners and influence
of NPM mutations on gene regulation.
F.A. Zmiri, N. Fotouhi-
Ardakani and M. Éric. HMR Res. Ctr., Montreal.
C54
770.3
Molecular basis of histone acetyllysine
recognition by the BRPF1 bromodomain.
K.C. Glass, A.
Poplawski, K. Hu, W. Lee, D. Peng, S. Carlson, X. Shi and M.
Westler. Albany Col. of Pharm. and Hlth. Sci., Colchester, VT,
Univ. of Wisconsin-Madison and Univ. of Texas MD Anderson
Cancer Ctr.
C55
770.4
A histone acetylation switch regulates H2A.Z
deposition by the SWR-C remodeling enzyme.
S. Watanabe
and C. Peterson. Univ. of Massachusetts Med. Sch.
C56
770.5
The regulation of microRNAs by Brahma-
related gene 1 in smooth muscle cells.
M. Chen and P. Herring.
Indiana Univ., Indianapolis.
C57
770.6
SWI/SNF remodels SIR3 heterochromatin
during transcription.
M.M. Rege and C.L. Peterson. Univ. of
Massachusetts Med. Sch.
771. CHROMATIN STRUCTURE IN GENE ACTIVATION
Poster
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C58
771.1
DNA repair regulates chromatin structure and
key transcription factors.
B. Snow, T. Estabrook, D-S. Pei and
P.R. Strauss. Northeastern Univ., Chongqing Inst. of Green
and Intelligent Technol., China.
772. HISTONE MODIFICATIONS
Poster
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C59
772.1
Kabuki syndrome missense mutations disrupt
the formation and histone methyltransferase activity of the
MLL2 core complex.
S.A. Shinsky, M. Hu, V.E. Vought, S.B.
Ng, M.J. Bamshad, J. Shendure and M.S. Cosgrove. SUNY
Upstate Med. Univ., Syracuse Univ. and Univ. of Washington.
C60
772.2
Histone acetyl transferase HBO1 and PHD
finger protein 17 (PHF17/JADE1) in epithelial cell regeneration.
M. Panchenko, A. Havasi, J. Haegele, R. Bonegio, T.
Ichimura, N. Siriwardana and J. Gall. Boston Univ. Sch. of
Med., Boston Med. Ctr. and Brigham and Women’s Hosp.
C61
772.3
A unique acquired resistance mechanism to
agents that target GLI (GANT61) in the Hedgehog signaling
pathway.
A. Agyeman, T. Mazunder and J. Houghton.
Cleveland Clin.
C62
772.4
Gender difference in response to dietary
genistein-induced chromatin remodeling of Wnt genes in
preneoplastic rat colon.
J.K. Bray, Y. Zhang and H. Chen. Univ.
of Illinois at Urbana-Champaign.
C63
772.5
Comprehensive characterization of
posttranslational modifications of histones using a novel high-
throughput middle-down proteomics approach.
S. Hess, A.
Kalli, A. Moradian and M.J. Sweredoski. Caltech.
C64
772.6
Understanding the combinatorial post-
translational modifications associated with histone H3
methylation in yeast.
I. Quasem and S. Fuchs. Tufts Univ.
773. GENOMICS
Poster
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C65
773.1
CTLA4 polymorphisms are associated with
severe pulmonary tuberculosis in a Chinese Han population.
C.
Wang, T. Jiang, L. Wei, J. Zhong, J. Liu, X. Zhang, D. Xu, Z.
Chen, Z. Li and J-C. Li. Zhejiang Univ. and The Sixth Hosp. of
Shaoxing, China.
C66
773.2
Pan-omic approaches to study the effect of
microgravity on skin endothelial cells submitted to endotoxic
insult.
W.J. Santos, E. Waddy, N. Chakraborty, A. Gautam, A.
Hoke, M. Jett and R. Hammamieh. U.S. Army Ctr. for Envrn.
Hlth. Res., Fort Detrick, MD.
MONDAY BIOCHEMISTRY
240
C67
773.3
Gripp-heel and the antiviral host-cell responses
against adenovirus.
C. Moyler, D.W. Wolf, M. Oberbaum,
J.A. Ives, S. Muhie, S.A. Miller, W.B. Jonas, M. Jett, R.
Hammamieh and M. Dorozko. U.S. Army Ctr. for Envrn.
Hlth. Res., Fort Detrick, MD, Hadassah Hebrew Univ. Med.
Ctr., Shaare Aedek Med. Ctr., Jerusalem and Samueli Inst.,
Alexandria, VA.
C68
773.4
Association of CTLA4 gene 49A/G
polymorphism with the incidence of type 1 diabetes mellitus in
the Iranian Kurdish population.
S. Ahmadi, J. Rostamzadeh,
D. Khosravi, N. Shkiba and H. Nabavi. Kurdistan Univ. of
Med. Sci. and Univ. of Kurdistan, Iran.
774. RNA IN THE CYTOPLASM: TRANSLATION AND
DEGRADATION
Poster
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C69
774.1
The role of the small GTPase Arf6 and its
potential regulation by miRNA-31 during early embryogenesis.
M.E. Dumas, N. Stepicheva and J.L. Song. Univ. of Delaware.
C70
774.2
Translational repression mediated by the
genotoxic agent sodium dichromate results in P-body formation
in S. cerevisiae.
W.L. Hopfauf, C. Bullard, S. Segner, B.
Rathmann, T. Koch, T. Wilson and S.P. Segal. Winona State
Univ.
775. ALTERNATIVE RNA SPLICING
Poster
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-2:35
pm
C71
775.1
Characterization of CD-209 isoforms with
carbohydrate recognition domain modified due to alternative
splicing.
L.L. Santos, L.H.S. Pereira, A.G. Taranto, M. Comar,
Jr., D.O. Lopes and J.M. Siqueira. Fed. Univ. of São João Del
Rei, Brazil.
C72
775.2
A highly conserved GC-rich element regulates
alternative splicing of mRNA for the variant thyroid hormone
receptor, TR
a2. S.H. Munroe. Marquette Univ.
C73
775.3
DEK is a possible IgM mRNA processing
regulator.
L.M. Turcios and M.L. Peterson. Univ. of Kentucky.
C74
775.4
Expression of mRNAs for two novel isoforms
of mouse heat shock factor 1 in mouse cells and tissues.
N.J.
Bachman, T. LaPilusa, T-W. Gong and M.I. Lomax. SUNY
Oneonta and Univ. of Michigan.
C75
775.5
RNAseq analysis of embryonic and postnatal
stages of mouse retina reveal transcriptome diversity and novel
alternatively spliced isoforms.
A.R. Banday, S. Congdon, S.A.
Seesi, I. Mandoiu and R.N. Kanadia. Univ. of Connecticut.
776. CATALYTIC RNA
Poster
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C76
776.1
Thermodynamic examination of the 4x2 bulge
of leadzyme.
A.C. Frost and N. Grover. Colorado Col.
777. MOLECULAR RECOGNITION OF RNA
Poster
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C77
777.1
Dissect conformational distribution and drug-
induced population shift of prokaryotic rRNA A-site.
X. Qi, J.
Lu, L. Zhao, A. Xia and T. Xia. Univ. of Florida, Univ. of Texas
at Dallas and Plano Senior H.S.
C78
777.2
Effect of pre-tRNA 5’ leader sequence variation
on the thermodynamic coupling and shared molecular
recognition between RNA and protein components of RNase P.
C.N. Niland, L.E. Yandek, U-P. Guenther, E. Jankowsky and
M.E. Harris. Case Western Reserve Univ.
C79
777.3
A novel approach to detecting RNA expression
in living cancer cells.
D. Weldon, A. Ko, Y. Williams, M. Hsu
and G. Johnston. EMD Millipore,Temecula, CA.
778. NON-CODING RNAS
Poster
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C80
778.1
Expanding the transcriptomes at unstable
tandem repeat loci.
P.D. Ladd, A.N. Dubinsky, N.S. Lomas,
H.A. Ko and A.R. La Spada. UCSD.
C81
778.2
miR-126 dependent decrease of skeletal
muscle microcirculation contribute to exercise intolerance in
pulmonary arterial hypertension.
F. Potus, S. Malenfant, S.
Breuils-Bonnet, G. Margaillan, S. Bonnet and S. Provencher.
Laval Univ., Canada.
C82
778.3
microRNA in Leishmania RNA virus 1.
J.O.
Odera and J. Porter-Kelley. Winston-Salem State Univ.
C83
778.4
The effect of aldosterone on the miRNA
content of a murine inner medullary collecting duct cell.
M.E.
Jacobs, L.A. Jeffers, A.K. Welch, C.S. Wingo and B.D. Cain.
Univ. of Florida and North Florida/South Georgia VA Med. Ctr.
C84
778.5
Influence of butyrate, a histone deacetylase
inhibitor, on expression profile of microRNAs in vascular
smooth muscle cells.
K. Ranganna, O.P. Mathew and S.G.
Milton. Texas Southern Univ.
BIOCHEMISTRY MONDAY
241
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779. RNA MODIFICATION: MECHANISM AND
FUNCTION
Poster
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C85
779.1
The role of NK1 receptor antagonist L-703,
606 in the experimental traumatic brain injury.
H. Duan, C. Hao,
S. Li and Y. Fan. First Clin. Col. of Shanxi Med. Univ., China.
780. RNA-BASED GENE REGULATION
Poster
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C86
780.1
RNAi screen reveals candidate mirnas
associated with the NF-
kB pathway. B.W. Redan, O. Motobar,
P. Tuzmen, R. Guha, N. Caplen and S.E. Martin. Purdue Univ.,
NCATS, NIH, Rockville and NCI, NIH.
C87
780.2
Miniaturization of commercial swine.
A.M.
Sough and J. Piedrahita. North Carolina State Univ.
C88
780.3
Binding of trans-regulatory elements to the
3’UTR adenine/uridine rich elements of human interleukin-3
mRNA.
M. Hernandez, J.A. Gonzalez, M. Martínez, P.
Gonzalez and C.I. Gonzalez. Univ. of Puerto Rico Med. Sci.
Campus and Rio Piedras Campus.
781. SMALL RNAS
Poster
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C89
781.1
Next-generation sequencing analysis of rat
heart left ventricle: novel microRNAs, novel isomiRs and
transmural distribution of microRNA expression.
A. Collins,
M.K. McGahon, J.M. Yarham, A. Daly, J. Guduric-Fuchs and
D.A. Simpson. Queen’s Univ. Belfast.
C90
781.2
microRNA-101 is a master regulator of
epigenetic machinery.
Y. Huang, H-C. Chen, S-J. Chen and
C-K. Chou. Chang Gung Univ., Taiwan.
C91
781.3
Cadmium toxicity and small non-coding RNAs
in animal cells.
L.A. Estrella, A.W. Cruz and J.A. Negron.
InterAmerican Univ. of Puerto Rico.
782. UBIQUITIN AND UBIQUITIN-LIKE
MODIFICATIONS
Poster
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C92
782.1
Cavin-1/PTRF as a new substrate of the SOCS3
E3 ubiquitin ligase complex.
T.M. Palmer, J. Williams, G. Baillie
and P. Pilch. Univ. of Glasgow and Boston Univ. Sch. of Med.
C93
782.2
Mechanism for recruitment of the endosome-
associated deubiquitinating enzyme, AMSH.
C.W. Davies, L.N.
Paul and C. Das. Purdue Univ.
C94
782.3
Prevention of ubiquitination at lysines in the N
tail, R, ICL4, and NBD2 domains disrupts CFTR trafficking and
immune response.
S. Lee, E. Schiffhauer, P.W. Kang and P.
Zeitlin. Johns Hopkins Univ. Sch. of Med.
C95
782.4
Sumoylation of Sall4B, an essential stem
cell transcription factor, regulates its stability, subcellular
localization and transcriptional activity.
F. Yang, Y. Ma and W.
Dai. NYU Sch. of Med., Tuxedo and Stony Brook Univ. Sch. of
Med.
C96
782.5
SUMO-binding sites in Nrf2.
T. Walters and I.J.
Arinze. Meharry Med. Col.
C97
782.6
Deubiquitinases as a signaling target of
oxidative stress.
T.T. Huang. NYU Sch. of Med.
C98
782.7
RNF4-dependent hybrid SUMO-ubiquitin
chains are signals for RAP80 and thereby mediate the
recruitment of BRCA1 to sites of DNA damage.
C.M. Guzzo,
C.E. Berndsen, J. Zhu, V. Gupta, A. Datta, R.A. Greenberg,
C. Wolberger and M.J. Matunis. Johns Hopkins Univ., James
Madison Univ. and Univ. of Pennsylvania.
C99
782.8
Characterization of an archaeal ubiquitin-like
protein SAMP1.
N.L. Hepowit, H.V. Miranda and J. Maupin-
Furlow. Univ. of Florida.
C100
782.9
Mapping the ubiquitination sites of the
transcriptional repressor ICER.
F.B. Woldeamanuel, M. Crow,
E. Sebasco and C.A. Molina. Montclair State Univ., NJ.
783. HOST-PATHOGEN INTERACTIONS AND
PROTEIN TRAFFICKING
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C101
783.1
Possible role for the adaptor protein complexes
in sorting of human papillomavirus.
A.M. Schlegel, J.A.
Chapman and S.K. Campos. Univ. of Arizona.
C102
783.2
Chorangiosis in placental malaria.
A.B.
Mcmichael, J.M. Moore, S. Burton and U. Okafor. Albany
State Univ. and Univ of Georgia.
C103
783.3
Phosphorylation of p57/coronin-1 regulates
phagocytosis through the modulation of actin-binding activity.
T. Oku, Y. Ando, M. Tsuiji, S. Toyoshima and T. Tsuji. Hoshi
Univ. and Japan Pharmacists Educ.Ctr., Tokyo.
C104
783.4
Pre-clinical vaccination of BALB/c mice with
five novel vaccines against a murine hookworm model.
P.H.
Comella. Concordia Col., MN.
784. MOLECULAR CHAPERONES: MECHANISM AND
FUNCTION
Poster
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C105
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