Draw up 0.01 mg/kg (0.01 mL/kg of epinephrine 1 mg/mL)
0.1 mg autoinjector
If not available, 0.15 mg autoinjector may be given
OR draw up 0.1 mg (0.1 mL of epinephrine 1 mg/mL)
10 to 25 kg (infants and children)
0.15 mg autoinjector
Draw up 0.15 mg (0.15 mL of epinephrine 1 mg/mL)
>25 to 50 kg
0.3 mg autoinjector
Draw up 0.3 mg (0.3 mL of epinephrine 1 mg/mL)
>50 kg
Draw up 0.5 mg (0.5 mL of epinephrine 1 mg/mL)
0.3 mg autoinjector
If the dose is to be drawn up, confirm that the 1 mg/mL epinephrine solution is being used. Draw up into a 1 mL syringe. The intramuscular injection is given into the mid-outer thigh.
If using an autoinjector, it should be held in place for three seconds after the injection, which is sufficient to deliver the dose.
Most patients respond to a single dose of intramuscular epinephrine. However, if there is no response or an inadequate response, then intramuscular epinephrine may be repeated at 5- to 15-minute intervals or sooner, if clinically indicated.
