When evaluating mg patients: When evaluating mg patients

When evaluating MG patients:

• When evaluating MG patients:

• In normal clinical practice

• or

• In the context of an experimental setting

Definition of Improved, Unchanged, Worsened is still a gray area:

• Definition of Improved, Unchanged, Worsened is still a gray area:

• Outcome may depend on how it is evaluated

• Clinically relevant changes need to be defined

• Is the minimal change of a specific score meaningful to truly describe patients’ improvement? (PROM)

• Need of further comparative studies

524 visits from 131 MG patients were compared on different scoring systems, Physician, INCB-MG, MGFA-PIS, QMG, MG-C, MG-ADL

• 524 visits from 131 MG patients were compared on different scoring systems, Physician, INCB-MG, MGFA-PIS, QMG, MG-C, MG-ADL

• Weighted Cohen K coefficient was used:

• 0 = no concordance, 1= complete concordance

• Values are given as 1-k: the higher 1-k value, the higher the discordance

Outcomes measures in MG should reflect the intrinsic features of the disease

• Outcomes measures in MG should reflect the intrinsic features of the disease

• Be useful both for clinical practice and experimental settings

• Have a good concordance between patients and physicians

• Need of further studies aimed at homogeneity, relevant for international studies