A dissertation submitted in fulfilment of the requirement for the degree of doctorate of science in the department of biochemistry and microbiology, faculty of science and
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Chapter Six 6. Conclusion The present study revealed that BAA possessed the highest anti-platelet aggregation activity, regardless of the agonists, in comparison with Aspirin, which is a known non- steroidal, anti-inflammatory drug (NSAID). BAA also possessed anti-inflamatory activity which complemented platelet functions. The possible mechanisms of action of BAA as a platelet aggregation inhibitor include: antithrombins, acetylcholinesterase activity inhibition, phosphodiesterase activity inhibition, calcium mobilization inhibition, the inhibition of release from dense granule content, anticoagulants, cyclooxgensase (COX- 2) activity inhibition, iron chelators, and enhanced SOD and CAT activity. These processes attenuate thrombosis formation and the progression of cardiovascular diseases (Robbin et al., 2006). In addition to their efficacy, the poor cytotoxicity of BAA indicated their safety as antiplatelet agents. To the best of the researcher’s knowledge, this is the first time that the antiplatelet aggregation activity and possible mechanisms of action of BA and the acetyl derivatives isolated from Melaleuca bracetata were investigated. 6.1 Recommendation for further studies The following suggestions are made for further studies: Synthesise betulinic acid derivatives by modifying compounds at C-28 moiety. Investigate the activity of compounds on G protein coupling receptors. Investigate the activity of compounds on the binding affinity of fibrinogen. Investigate the activity of compounds on the biosynthesis of thromboxane A 2. Investigate the activity of compounds on Glycoprotein IIb/IIIa for platelet aggregation. 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Details of preparation of some reagents Kataloq: bitstream bitstream -> Issn 2409-0255 (Print) issn 2410-1427 (Online) bitstream -> A review of international experience bitstream -> Yeni və orijinal nəticə və metodların təqdim edilməsi bitstream -> 1. nsan inki afı Orqanizmin qurulu u 3 bitstream -> &&3&5B&&&&&Si&ER5ettiRE2 bitstream -> Dövlət Statistika Komitəsinin məlumatına Təranə Həsənova bəzən abortlardan bitstream -> Hamlet İsaxanlı Təsisçi və Rektor bitstream -> Stimularea electrică funcţională Radu Breahnă, Irina Turtureanu bitstream -> Udc 616. 12-009. 72-056. 52-008. 9-092: 612. 018 Adipocytokine changes in patients with stable angina and obesity bitstream -> L. A. MƏMMƏdov, E.Ç. ƏKBƏrov, H.Ə. ƏKBƏrov Yüklə 3,8 Mb. Dostları ilə paylaş:
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