Chapter Six
6.
Conclusion
The present study revealed that BAA possessed the highest anti-platelet aggregation
activity, regardless of the agonists, in comparison with Aspirin, which is a known non-
steroidal, anti-inflammatory drug (NSAID). BAA also possessed anti-inflamatory activity
which complemented platelet functions. The possible mechanisms of action of BAA as a
platelet aggregation inhibitor include: antithrombins, acetylcholinesterase activity
inhibition, phosphodiesterase activity inhibition, calcium mobilization inhibition, the
inhibition of release from dense granule content, anticoagulants, cyclooxgensase (COX-
2) activity inhibition, iron chelators, and enhanced SOD and CAT activity. These
processes attenuate thrombosis formation and the progression of cardiovascular
diseases (Robbin et al., 2006). In addition to their efficacy, the poor cytotoxicity of BAA
indicated their safety as antiplatelet agents. To the best of the
researcher’s
knowledge,
this is the first time that the antiplatelet aggregation activity and possible mechanisms of
action of BA and the acetyl derivatives isolated from Melaleuca bracetata were
investigated.
6.1
Recommendation for further studies
The following suggestions are made for further studies:
Synthesise betulinic acid derivatives by modifying compounds at C-28 moiety.
Investigate the activity of compounds on G protein coupling receptors.
Investigate the activity of compounds on the binding affinity of fibrinogen.
Investigate the activity of compounds on the biosynthesis of thromboxane A
2.
Investigate the activity of compounds on Glycoprotein IIb/IIIa for platelet
aggregation.
Investigate the activity of compounds on cytokines such as P-selectin, CD40L
and interleukin.
6-117
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PPENDIX
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A. Details of preparation of some reagents
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