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Key words:
nosocomial infections, acinetobacter spp., antibacterial treatment resistance
AN-1401-033
EVALUETION OF HAEMOSTASIS AND ENDOTHELIAL DYSFUNCTION IN PATIENT WITH
COMMUNITY-ACQUIRED PNEUMONIA
Bedilo N.V.
1,2
, Vorobyova N.A.
1,2,3
, Ismailova N.V.
1,2,
Veschagina N.A.
1
, Nasonov I.Ya.
1
,
MaluginYu.Yu.
1
1Volosevich First Arkhangelsk Clinical Hospital, Arkhangelsk, Russia; 2Northern State Medical University,
Arkhangelsk, Russia; 3Hematology Research Centerof the Ministry of Health of the Russian
Federation,Northern Branch, Arkhangelsk, Russia
correspondence to:
Bedilo Natalia Vitalyevna
e-mail:
natalya.bedilo@yandex.ru
Abstract:
The article deals with a study of hemostasis (D-dimer, soluble fibrin-monomer complex, time fibrin
self-assemblance, antitrombin III, fibrin
о
gen), endothelial dysfunction (f. Willebrand and acivity of
plasminogen activators inhibitor type 1) and CRP in 61 patients with CAP in the day of admission and before
discharge from hospital. 17 patients had a severe pneumonia, 6 people died. The levels of all markers
(except AT-3) were increased on admission and were reduced before discharge, but within the normal range
to include only FW, CRP and time fibrin self-assemblance. DD, CRP and PAI-1 were dependent on the
severity of the CAP, severity of SIRS and extent of the inflammatory process. The risk of severe pneumonia
increased with the level of D-dimer in the onset of the disease more than 2.0 mkg mL-1 (OR = 21.8, 95% CI:
3,09-154,8), with the results of TP-test less than 0.5 ( RR = 2.68, 95% CI: 1,23-5,84), with CRP greater than
200 mg l-1 (OR = 4.6, 95% CI: 1,87-11,45) and PAI-1 activity more than 30 U l-1 (OR = 2.05, 95% CI: 0,88-
4,74). Rg-CAP outcomes best reflect the level of DD, measured prior to discharge patients.
Key words:
community-acquired pneumonia; hemostasis, endothelial dysfunction
AN-1401-038
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