Chelation and Detoxification chelation. Clinical Metal Toxicology

The first symposia on EDTA Chelation Therapy

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The first symposia on EDTA Chelation Therapy.

In 1959 and 1960 Marvin J. Seven, who had six years experience with chelation therapy helped to arrange the first two major symposia on chelation therapy. The proceedings of these conventions were published as a textbook “Metal Binding in Medicine” and as “Proceedings of a conference on Biological Aspects of Metal Binding”. These books, if still available can be recommended to everyone who is studying chelation. This is the base for our present knowledge of the phenomenon of chelation.Unfortunately Seven died in 1961 and progress of chelation therapy in the USA was severely retarded in the next decade.

Other developments in EDTA chelation therapy

Outside the USA, in the Soviet Union and Czechoslovakia important scientific and clinical work was conducted independent from the development in the USA. The group of Zechmeister, Brucknerova, Malinovska, Hadasova and others at the University of Brno published their first results of the therapeutic application of chelation in patients with atherosclerotic disease in 1966.Still more impressive is their experimental work with limited budgets on the effect of calcification of the arterial wall. It was this research that came to the attention of the Chelation society in the USA who hurried to bring Anton Zechmeister to the USA in 1986 to testify for the FDA. It also led to the internationally organized symposia in Plzen, Czechoslovakia, on the Interaction of Chelating agents and Metals.

In the USA emeritus professor Martin Rubin, former associate of Frederick Bersworth may be considered as one of the earliest experts on the scientific clinical application of EDTA chelation therapy. He was the president of the International Chelation Research Foundation and wrote several basic scientific papers on the subject.


In 1973 the American Academy of Medical Preventics (AAMP) was founded “ to perform and encourage investigational research into the nature of the aging process in man and to establish standards for the diagnosis and for the medical treatment of atherosclerotic disease and all associated phenomena” In the 1977 members of AAMP realized that chelation therapy needed to become a well defined sub-specialty of medicine, if it ever would get recognition. In 1981 they made a proposal to the board of AAMP to establish a separate organization called the American Board of Chelation Therapy (ABCT). The specific purpose of this organization was and remains the testing of the proficiency of physicians to perform EDTA Chelation therapy. In 1995 the International Board for Chelation Therapy (IBCT) emerged from ABCT, intended to serve the interests of the non-American doctors. The newest development is that both sister organizations expanded their objectives and IBCT changed already its name into The International Board of Clinical Metal Toxicology (IBCMT). This was followed in 2003 by ABCT which name currently is ABCMT. Both organizations run a website since 2001.

In 1988 ABCT conducted a workshop for the first time outside the USA, in the Netherlands. Presently, IBCMT conducts every year at least two international workshops in addition to the two combined workshops with ABCT in the USA. The workshops are usually followed by the written or oral exams, which are needed to become certified in Clinical Metal Toxicology.


In spite of, or maybe because of growing popularity and acceptance of EDTA chelation therapy attacks from mainstream medicine, surgeons and cardiologists continue. Most of them are individual without providing well-founded arguments: “it is quackery”; “it is not scientifically proven”; “it is dangerous, and many deaths have been reported” etc. But some of them are well organized and even well founded, such as the “PATCH Study” of 2001. The desire to hurt the chelation community however is usually greater than the patience for accurate scientific work. So far all these studies have been flawed for not following the protocol and manipulating statistics. This is especially painful for the Patch Study, which was well subsidized and appeared in 2001 in an authoritative magazine such as the Journal of the American Medical Association (JAMA). This study claimed that EDTA did not work. It was heavily criticized for the poor setup and manipulation of the statistics, by several authorities, amongst them a cardiologist with outstanding reputation.

Another study, conducted by Guldager and Jorgensen in Denmark, early in the nineties, also tried to prove that EDTA chelation therapy was not effective. However, when taken into court by the Danish Chelationists, it turned out that they had not followed the protocol, and even that a patient who got benefit from the treatment was told that this would not be recorded, because “then they could not prove that EDTA doesn’t work”.

The Netherlands

In 1983 the Dutch Government ruled that there was insufficient evidence for the efficacy of EDTA in the treatment of Atherosclerosis, and the administration of EDTA and other chelating agents for the treatment of heavy metal intoxication should be restricted to well-equipped hospitals. The Chief Heath inspector reacted with a letter to all physicians, stating: “physicians who continue to describe chelation therapy on ill-founded indications (other than heavy metal intoxication) should seriously consider the possibility that their activity will compel the Health Inspection to disciplinary action. Three Dutch doctors committed a unique fact in Dutch Medical History and brought the State of the Netherlands in 1985 to court, in order to have the Inspector’s letter revoked. In first instance they lost the case. But after much deliberation, and hiring another attorney (for considerable personal investment) they appealed. In March 1986 the High Court of Justice pronounced that the verdict of 1985 should be quashed, The Chief Health Inspector was ordered to publish within three weeks a new letter stating that his first letter was unlawful. Since that time, EDTA Chelation therapy is tolerated in the Netherlands, and no doctor has been challenged for conducting this treatment.

Present situation with regard to EDTA

At this time we rather refer to Clinical Metal Toxicology when we discuss chelation therapy, because “chelation” is still too much associated with the misconception that EDTA could chelate calcium out of the calcified plaques in the arteries. We use chelating agent for many more pathological conditions than atherosclerosis.

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