He jolt that ran through The Rockefeller University campus

Yüklə 194,94 Kb.
Pdf görüntüsü
ölçüsü194,94 Kb.


he jolt that ran through The

Rockefeller University campus

Monday morning with the news

that Günter Blobel had won the Nobel

Prize in physiology or medicine was felt

keenly by those most closely connected

to his work—the postdocs, graduate stu-

dents and technicians in his laboratory.

It did not take long for the news—

announced at 5:30 a.m. Eastern

Standard Time by the Nobel Assembly of

the Karolinska Institute in Sweden—to

reach the students, and the information

set off a wave of excited telephone calls

in various languages to confirm that the

rumor was true. Others checked the

World Wide Web, television and radio 

to verify the claim. The announcement

validated for them Blobel’s impressive

stature in the field of cell biology.

Virtually all of them had come to

Rockefeller specifically for the chance 

to work in his laboratory.

Many were roused from sleep

between 5:30 and 6 a.m. by members of

the media desperate to get in touch with

Blobel. Some press outlets apparently got

hold of a list of those in the lab and

began calling them one by one. Elias

Coutavas, a postdoctoral associate from

New York City, received a call just before

6 a.m. “The person on the other end

said. ‘This is CBS news. I don’t know if

you’ve heard, but Dr. Blobel has won the

Nobel Prize. Do you have his number?’

After I hung up the phone, I was wired.

I’m not a morning person, so normally I

would go back to sleep. Instead I got

dressed and came in to the lab.”

Others had similar experiences,

Jonathan Rosenblum, a postdoc from

New Jersey, received calls from CBS and

the Associated Press radio. Susana

Chaves, a guest investigator from

Portugal, was contacted by CBS and the

Portuguese press. All primarily wanted

to reach Blobel, but some asked for com-

ments from the lab members as well.

Jost Enninga, a graduate exchange

student, received a telephone call at 5:30

a.m. from his parents in Germany who

had just heard the news announced by

German media at 11:30 a.m. local time.

Enninga woke up his roommate, Ivan

Karnauchov, a postdoctoral fellow from

Russia, to pass on the scoop.

“It was very exciting for us,”

K a rnauchov says. “I was having tro u b l e

saying what I felt because I kept switch-

ing between Russian, German and

English. We were, of course, very happy. ”

Hualin Zhong, a postdoctoral associ-

ate, heard the news on the radio at home

and then confirmed it by checking the

Web. “I was very happy and excited,” she

says. “I was hoping before I came here

[in June 1998] that he would win when I

was here. It was great news because he

really deserves it. I’m very glad to have

the chance to work with him and share

such an exciting moment.”

OCTOBER 15, 1999   VOLUME 10, NUMBER 5 






Cell biology legacy


Don’t forget the ZIP


Calendar of events

Blobel lab members revel in the buzz of Nobel Prize announcement

By Jim Stallard

The phone call heard

round the world

By Joseph Bonner

Blobel wins 1999 Nobel Prize in medicine

Members of the Blobel lab gathered on the steps of Founder’s Hall after the media frenzy abated on Mon.,

Oct. 11. Photo by Joseph Bonner

see Call, page 3


he Nobel Assembly at the

Karolinska Institute awarded the

1999 Nobel Prize in physiology or

medicine to Rockefeller Professor Günter

Blobel for the discovery that “proteins

have intrinsic signals that govern their

transport and localization in the cell.”

The 20th scientist associated with the

university to garner this award, he will

receive a gold medal and a cash prize of

$960,000 at the Nobel Assembly in

Stockholm, Sweden, on December 10.

“I am delighted that my colleague,

Günter Blobel, is Rockefeller’s newest

Nobel laureate,” says President Arnold J.

Levine. “It is indeed fitting that, as we

near the close of the century and the

approaching Centennial, Günter should

receive this award for research that has

deep roots in Rockefeller history and

represents great promise for the treat-

ment of human disease.”

Blobel, the university’s John D.

Rockefeller Jr. Pro f e s s o r, heads the

L a b o r a t o ry of Cell Biology and is an inves-

tigator at the Howard Hughes Medical

Institute. Born in Wa l t e r s d o rf, Germ a n y,

on May 21, 1936, he received his medical

d e g ree in 1960 from the University of

Tübingen and a doctoral degree in 

oncology in 1967 from the University of

Wisconsin at Madison, where he worked

with Van R. Potter in the McArd l e

L a b o r a t o ry for Cancer Researc h .

He joined Rockefeller in 1967 as a

postdoctoral fellow in the cell biology

laboratory of Professor Emeritus Philip

Siekevitz and Nobel laureate George

Palade. Blobel was appointed an assis-

tant professor in 1969, associate profes-

sor in 1973, professor in 1976 and John

D. Rockefeller Jr. Professor in 1992. He

received an HHMI appointment in 1986

when HHMI established a unit at


In addition to a 1993 Albert Lasker

Basic Medical Research Award, Blobel

has received many awards, including 

the King Faisal Award (with James

Rothman and H. Pelham) in 1996; 

the Ciba Drew Award in Biomedical

Research (with Levine and J.

Schlessinger) in 1995; the National

Academy of Sciences’ 1978 U.S. Steel

Foundation Award in Molecular Biology;

a 1982 Gairdner Foundation

International Award; the 1983 Warburg

Medal, the highest award of the German

Biochemical Society; the V. D. Mattia

Award of the Roche Institute of

Molecular Biology; the E. B. Wilson

Award from the American Society for

Cell Biology (with David Sabatini);

Columbia University’s Louisa Gross

Horwitz Prize; the Waterford Bio-

Medical Science Award; and the Max-

Planck Forschungspreis.

He became a member of the

Leopoldina and was elected to member-

ship in the U.S. National Academy of

Sciences in 1983, the year he re c e i v e d

the Academy’s Richard Lounsbery Aw a rd .

Blobel is founder and president of the

board of directors of the Friends of

Dresden Inc. Blobel and his wife, Laura

Maioglio, owner of Barbetta Restaurant

in New York City, reside in New York

City and Fubine, Piemonte, Italy.

Professor Günter Blobel, Rockefeller University’s

20th Nobel Prize winner, waves to cheering 

members of the campus community as he walks

with his wife, Laura Maioglio, to Monday’s news 

conference, below. Photo by Reuters

Photo by Paul Schmeck


rofessor Günter Blobel thought 

the early morning phone call last

Monday (Oct. 11) was a prank

from one of his colleagues. But indeed, 

it was Nils Ringertz, the secretary of 

the Nobel Committee, calling from

Stockholm, Sweden, to inform Blobel

that he was the recipient of the 1999

Nobel Prize for physiology or medicine.

The 5 a.m. call signaled the beginning 

of a long day that would transform

Blobel into an international figure.

After attempts by reporters to reach

him through members of his lab (see

story, below), Blobel was greeted by an

army of photographers and reporters as

he entered the 66th Street gate around

10 a.m. Stopping briefly to give an

impromptu news conference (an official

one was scheduled for 11 a.m.), Blobel

retreated to his lab in Rockefeller

Research Building, journalists on his

heels to capture his every move and


Photographers recorded the steps of

Blobel and his wife, Laura Maioglio, as

they walked hand-in-hand from Gasser

Hall to Caspary Auditorium, not unlike

the First Couple strolling across the

White House South Lawn.

Caspary Auditorium was filled with

TV crews and photographers from the

United States, Germany, Italy and Great

Britain and well-wishers from the cam-

pus community. President Arnold J.

Levine was stuck at a scientific meeting

on Monday and, with instructions to

notify the campus by e-mail and voice

see Revel, page 2

Zhong called Beatriz Fontoura, a

postdoctoral associate from Brazil, at

8:30 a.m. to tell her what happened. “It

was a great way to wake up,” Fontoura

says. “After he won the Lasker Award [in

1993] there was an expectation that he

might get the Nobel, but it’s always a

surprise. He easily could have won it

long before now.”

For the lab members, the day was

one of celebration and bemusement

watching reporters mill around the hall-

way and camera operators scrambling to

get footage of Blobel in a laboratory set-

ting. Shots of Blobel pipetting drew

much lab attention. There was a small

celebration with toasts during the day,

with Blobel popping in to join the crowd

when he could spare a minute between


The lab knew Blobel was a strong can-

didate for the honor, and many had

speculated hopefully that this might be

the year. Joe Glavy, a postdoctoral associ-

ate, said that as Samuel Dales, an adjunct

faculty member, left the office on Friday

he asked everyone to hope for Blobel to

win. “I told my parents he had a good

chance of winning,” Glavy says. “They

called me at 8 a.m. (Monday) saying they

had heard the name on the radio along

with the words ‘Nobel Prize.’ The first

thing I asked was, ‘Did he win it alone?’

They said Blobel was the only name they

h e a rd, so I knew what that meant.”

Blobel’s influence extends to those

who have passed through his lab and

moved on to other positions. Lucy

Pemberton, a postdoctoral associate

from England who has been in Blobel’s

laboratory the longest of the current

members, said she found out about the

Nobel from former Blobel postdoc Neris

Bonfaci, who called her from Turin, Italy.

“I was just incredibly excited,”

Pemberton says. “He deserves it more

than anyone. The old postdocs have

been calling here all day really happy

about the news.”

Some former lab members are

now faculty members at Rockefeller.

Assistant Professor Mike Rout, who

worked in Blobel’s lab for seven years,

found out about the Nobel honor 

when a reporter for National Public

Radio called him at home asking for

help in tracking down Blobel.

“I t ’s absolutely wonderful,” says Rout,

who was born and educated in England

but came to Rockefeller because of

B l o b e l ’s reputation. “It couldn’t be more

w e l l - d e s e rved. Günter is a fabulous

re s e a rcher and person. In all respects, he

is certainly one of the brilliant biologists

of the century. It was a tremendous privi-

lege to work with him in his laboratory.

He has always been amazingly genero u s . ”

Bobel’s generosity was displayed in

another way, when he announced 

that he will donate his prize money,

$960,000, to rebuild historical 

structures in Dresden, Germany and

Fubine, Italy. Enninga, was particularly

impressed by Blobel’s gesture.

“I think it’s a great sign for peace,” 

he says. “It’s a way of saying ‘we will 

not let the crimes of war destroy an

entire cultural life’.”





OCTOBER 15,  1999

Looking Back: The RU Tradition in Cell Biology 

By Betsy Hanson


n his comments at the press confer-

ence announcing his Nobel Prize,

Günter Blobel thanked his teachers,

mentors and colleagues. First was Van R.

Potter, his doctoral advisor at the

University of Wisconsin at Madison, and

then George Palade, Professor Emeritus

Philip Siekevitz, and David D. Sabatini,

leaders in the world-renowned cell biol-

ogy laboratory at Rockefeller University

that Blobel joined in 1967. By that time

Rockefeller had a tradition of cell biolo-

gy extending back more than 20 years,

and was famous as the place where cell

biology developed as a field. George

Palade was one of the founders of that


Palade came to Rockefeller in 1946, a

year after Rockefeller researchers Keith

Porter and Albert Claude and Ernest

Fullam of the Interchemical Corporation

published the first image of a cell as seen

with an electron microscope. With its

high resolution and magnification, the

electron microscope opened new hori-

zons for exploring the interiors of cells.

Earlier researchers using light micro-

scopes had been able to identify the

shapes of cells, and to see the nucleus

and the shadowy figures of other

organelles, which seemed to float in a

disorganized chemical soup. The elec-

tron microscope revealed and brought

into focus an array of new structures

within the cell. 

With Porter, Palade set out to explore

and map the territory inside eukaryotic

cells – the kind of cell that contains a

nucleus, and that makes up the human

body, for example. They recognized early

on that the electron microscope provid-

ed only a static snapshot of the cell. To

learn how the structures inside carried

out various processes other techniques

were needed – cell fractionation, bio-

chemical analysis, pulse-chase proce-

dures and autoradiography. In time,

research in the Cytology Laboratory

revealed a surprise for biologists: all cells

in the body, whether from liver, heart, or

skin, for example, have the same basic

internal organization. The Nobel Prize

was awarded to Palade, Claude and de

Duve for the connections they made

between cellular structures and their


Palade and Porter’s first work at

Rockefeller was devoted to perfecting the

techniques of electron microscopy. The

methods Palade developed for fixing

cells – preparing them for viewing with

the electron microscope – and the

microtome Porter invented for creating

ultra-thin specimens greatly improved

the quality of electron micrographs.

Using the new techniques, in 1952

Palade described the internal structure of

the mitochondria, the sausage-shaped

bodies that serve as the powerhouses of

the cell. 

At about the same time, Palade dis-

covered a new structure in the cell, first

termed the “Palade granule” and now

called the ribosome, that synthesizes

proteins. In addition to making this find-

ing, in the next decades Palade and his

colleagues unveiled the pathway in the

cell from the synthesis of proteins to

their secretion, in particular the synthe-

sis and secretion of enzymes by pancreas

cells. Much of this work was done in

collaboration with Professor Emeritus

Philip Siekevitz, who joined Palade’s lab

in 1954, and later with James D.

Jamieson. When Siekevitz became a full

professor in 1966, the laboratory became

the Palade-Siekevitz lab. 

This work laid the foundation for the

signal hypothesis by Blobel and Sabatini,

which postulated that newly synthesized

proteins contain signals that guide their

transport to specific addresses in the

cell. Blobel’s work has also elaborated

upon another research interest of Palade

and Siekevitz – the structure and func-

tion of cellular membranes.

Blobel joined the Palade-Siekevitz lab

in 1967 as a postdoctoral fellow. “When

I started in Palade’s lab, the various

structures in the cell had been identified

with the electron microscope, and it was

known that proteins have to cross mem-

branes, but it wasn’t known what the

mechanism was,” says Blobel. His

accomplishments are direct intellectual

descendants of those of the earlier

Rockefeller group.

“Blobel’s excellent work,” says

Siekevitz, “his biochemical experiments

and results, are the culmination of

decades of work done at Rockefeller on

how newly synthesized proteins traverse

the cell.”

In addition, Blobel points to

Rockefeller’s Nobel-prize winning history

in protein chemistry as an influence on

his work. At Rockefeller, Stanford Moore

and William H. Stein worked out the

composition of proteins, and Professor

Emeritus R. Bruce Merrifield developed a

method of synthesizing them. Says

Blobel, “My work connects the chemical

work done by these giants to the work

that has been done in cell biology, in

particular by George Palade.”

The tradition continues today in

Blobel’s lab and in the labs of the next

generation of cell biologists across cam-

pus, such as Michael Rout, Sanford

Simon, Titia de Lange, Thomas Sakmar

and others.

Nobel Laureates of The

Rockefeller University


ince the institution’s founding in

1901, 20 Nobel Prize winners 

have been associated with the 

university. Of these, two are Rockefeller

graduates (Edelman and Baltimore) and

five laureates are current members of the

Rockefeller faculty (Blobel, de Duve,

Lederberg, Merrifield and Wiesel). Prizes

were awarded for physiology or medi-

cine, unless otherwise noted.

1912 Alexis Carrel

1930 Karl Landsteiner 

1944 Herbert S. Gasser 

1946 John H. Northrop and Wendell F.

Stanley, with James Sumner


1953 Fritz Lipmann, with Hans Krebs

1958 Edward L. Tatum, with George


1958 Joshua Lederberg

1966 Peyton Rous, with Charles B.


1967 H. Keffer Hartline, with Ragnar

Granit and George Wald

1972 Gerald M. Edelman, with Rodney

R. Porter

1972 Stanford Moore and William H.

Stein, with Christian B. Anfinsen


1974 Albert Claude; Christian de

Duve; George E. Palade 

1975 David Baltimore, with Renato

Dulbecco and Howard M. Temin

1981 Torsten Wiesel, with David H.


1984 R. Bruce Merrifield 


1999 Günter Blobel

Nobel laureates gather for a photo opportunity in 1975:From left, standing: George Palade, Albert Claude,

Standard Moore, Christian de Duve. From left, seated:H. Keffer Hartline, Gerald Edelman and Fritz Lipmann.

Photo courtesy The Rockefeller University Archives

Günter Blobel stands with fellow Nobel laureate James Watson (left) and Qais Al-Awqati at the reception at

Barbetta Restaurant Monday evening. Al-Awqati, Blobel's close personal friend of 40 years, is a physician in the

D e p a rtment of Medicine at Columbia University College of Physicians and Surgeons. Photo by Elias Coutavas



continued from page 1

OCTOBER 15,  1999






rofessor Günter Blobel was award-

ed the Nobel Prize for his work on

translocation, the process by which

newly made proteins are transported

across the membranes of cell structures

called organelles. Work in Blobel’s labo-

ratory revealed the existence of a ZIP

code system in the cell. Each newly

made protein has an organelle-specific

address, a stretch of the protein referred

to as a signal sequence that is recognized

by receptors on an organelle’s surface.

Blobel and his colleagues also showed

that, for at least one organelle called the

endoplasmic reticulum, the binding of

the signal sequence to its receptor opens

a watery channel in the membrane

through which the protein can travel.

Because the accurate distribution of pro-

teins to their proper places in the cell  is

necessary for a cell to function, these

findings have an immediate bearing on

many diseases, including cystic fibrosis,

Alzheimer’s disease and AIDS, and on

the pharmaceutical industry.

An average cell possesses about a bil-

lion protein molecules that exist in thou-

sands of types and constantly need

replacement. Making proteins and ship-

ping them to appropriate destinations,

such as the cell's internal organelles, is a

vital activity in cells. Proteins are  manu-

factured by cellular structures called

ribosomes. Up until the early 1970s, the

mechanism by which proteins are trans-

ported from ribosomes and integrated

into other organelles or transported out

of the cell remained unknown. To try

and solve this mystery, Rockefeller

researchers David Sabatini (now at New

York University) and Blobel proposed

what they called the signal hypothesis,

in which a signal sequence—a short

stretch of amino acids—allows the ribo-

some to attach to the membrane of the

endoplasmic reticulum, an organelle

responsible for synthesizing proteins. As

translation continues, the protein, led by

the signal sequence, passes through the

membrane and the signal sequence is

cleaved off.

Blobel decided to test this hypothesis

by mimicking the translocation process

in a test tube. Blobel set up a cell-free

system containing mRNA and microso-

mal membranes isolated from liver cells

in a rat, but the membranes blocked the

synthesis of the protein (translation).

Cells taken from organs of other animals

also inhibited translation until he decid-

ed to use dog pancreas cells. When he

studied the translation products on an

SDS gel, he found that they migrated

faster than the precursors of the proteins

made without the membranes. Blobel

concluded that when a protein is

translocated across the microsomal

membrane, the signal peptide is cleaved

off, producing a protein that migrates

faster in the gel.

Blobel and researchers elsewhere

went on to show that proteins associated

with all types of cellular compart-

ments—mitochondria, chloroplasts,

etc.—used different signal sequences, or

ZIP codes, to target membranes.

“There are thousands of cellular pro-

teins that have to be transported across

very specific membranes,” says Blobel.

Research in Blobel’s lab began to dis-

sect the translocation process into the

endoplasmic reticulum. In 1980, he and

his colleagues discovered the signal-

recognition particle (SRP), and then 

its receptor on the endoplasmic reticu-

lum membrane. They showed that the

SRP, which consists of RNA and six

polypeptide chains, recognizes the signal

sequence and directs the whole complex

to the SRP receptor on the membrane.

In the early 1990s, Blobel and

Associate Professor Sanford Simon

showed that the signal sequence is the

key that opens a protein-conducting

channel through the endoplasmic reticu-

lum membrane, enabling translocation.

Current research in Blobel’s laboratory

also explores the movement of proteins

across nuclear pore complexes (NPCs),

huge protein units suspended in the cir-

cular openings within the membrane of

a cell’s nucleus. NPCs can accommodate

the passage of large molecular assem-

blies, such as RNA or DNA bound to

proteins. Each NPC mediates as many as

10 import and 10 export events per sec-

ond. His laboratory recently determined

the three-dimensional structure of a

complex of transport factor called karyo-



2 and Ran, which binds to pro-

teins and targets them to the NPC.

Blobel says that the picture of protein

translocation is far from complete. “It is

like a mosaic, made up of very beautiful

stones,” says Blobel. “But when you get

close, you notice that some stones are


“You may be able to make out the

outline of a face, for example, but some

of the features are difficult to distinguish.

Our job is to complete the mosaic.”

In the signal hypothesis, a signal peptide is formed as a part of the protein. With the help of binding pro-

teins, the signal peptide directs the ribosome to a channel in the endoplasmic reticulum. The growing pro-

tein chain penetrates the channel, the signal peptide is cleaved, and the completed protein is released into

the lumen of the endoplasmic reticulum. The protein is subsequently transported out of the cell. 

Photo courtesy of Nobel Foundation

Molecular ZIP codes shuttle proteins around cell

By Joseph Bonner

mail of the pending news conference,

appointed Mariellen Gallagher, vice pres-

ident for communications and public

affairs, and Professor James Darnell as


“For all these achievements, we have

recognized him for many, many years as

a cherished colleague,” Darnell told the

audience. “Today he gets worldwide


Reflecting on his work, Blobel

acknowledged the support he has

received from the Howard Hughes

Medical Institute for more than 10 years,

and noted the inspiration he receives

from “coming here in the morning,

walking in the footsteps of...all the other

important scientists who have done

major breakthrough discoveries.”

Taking questions from the audience,

Blobel also thanked his wife, whom, he

said, “has tolerated the long hours in the

lab.” Purnell Choppin, a former

Rockefeller professor and now president

of HHMI, said that the Nobel Prize hap-

pens when “you take a brilliant and

innovative scientist like Günter and put

him in a place like Rockefeller, which for

almost 100 years has been dedicated to

pursuing biological research at the basic


The New York Timesreported that

Blobel’s comments about disappoint-

ments in research, “such as when your

grants and papers are rejected,” drew

“thunderous applause from the hundreds

of sympathetic colleagues and younger

scientists who packed the auditorium.”

Near the end of his remarks about his

re s e a rch, Blobel showed some slides of

the German city of Dresden. Blobel

recounted witnessing the bombing of

D resden in 1945 when he was eight and

a half years old and the ensuing

f i re s t o rm. He then announced that he

was going to donate most of the

$960,000 prize to a philanthropy he

founded four years ago called Friends of

D resden for the restoration of the historic

F r a u e n k i rche and a synagogue that were

d e s t royed during World War II. The re s t

of the prize money will help to re s t o re

p a rt of the historic center of his wife’s

hometown of Fubine in Piemonte, Italy.

President Levine and his wife Linda,

who were at a reception at Blobel’s wife’s

restaurant Barbetta Monday evening,

hosted a reception at the President’s

House the following night. At the

President’s House, he said Blobel’s Nobel

Prize “means a lot inside the university,

from the security guard right through to

the president.

“And outside the university it means

that this institution has yet another prize

that’s very visible. We have quietly

labored doing science here and the good

visibility, I think is good for New York

City and the university. I think Günter

has given us something both inside and

outside the institution.”

As proof of this, Mayor Rudy Giuliani

declared Thurs., Oct. 14, “Dr. Günter

Blobel Day” in New York City.

President Levine toasts Günter Blobel at the President’s House last Tuesday night. Photo by Paul Schmeck

David Rockefeller (center) talks with President Levine and Günter Blobel. Rockefeller rushed back to New

York after hearing the news on the radio at his home in Maine. Photo by Paul Schmeck



continued from page 1




is published each Friday 

throughout the academic year by 

The Rockefeller University,

1230 York Avenue,

New York, NY 10021-6399

Phone: 212-327-8967


Arnold J. Levine , President

Mariellen Gallagher , Vice President of Communications

and Public Affairs

Joseph Bonner , Director of Communications

Lisa Stillman, Associate Director, Media Relations and

Acting Editor

Jim Stallar d, Science Writer

Media Resource Service Center , Pre-press and Offset 

Ideas and submissions can be sent interoffice (Box 68), 

by electronic mail (newsno), or by fax (212-327-7876).

Copyright, 1999. The Rockefeller University.

For permission to quote or reprint material from this

newsletter, please contact the editor.

The Rockefeller University is an equal opportunity/affirma-

tive action employer.


9 a.m.–5 p.m. The Living Brain. Mary

E. Hatten, RU; Mark H. Ellisman, UC

San Diego; Andrea Brand, U. of

Cambridge; Nicholas Spitzer, UC San

Diego;  David Colman, Mount Sinai

School of Medicine; and Ronald D.

McKay, NINDS, NIH. New York Society

of Experimental Microscopists 1999

Presidential Symposium. 714 Hunter

West Building, Hunter College, 68th

St. at Lexington Ave. Contact Philip L.

Leopold, 746-8808, pleopold@mail.med.



12 p.m. High Sensitivity Stable

Isotope Tracers Applied to Whole

Body Polyunsaturated Fatty Acid

Metabolism. Tom Brenna, Associate

Professor, Division of Nutritional

Sciences, Cornell U. Seminar. 110B

Nurses Residence.

4 p.m. The Phenomenology of

Modulated Phases: Magnetic Films,

Polymers and Membranes. Center for

Studies in Physics and Biology Seminar.

B Level Conference Room, Smith Hall

Annex. Tea, 3:30 p.m. Contact Matthew

Turner, 327-8184.


11 a.m. Coping with Replication

Complex “Train Wrecks” Using

Escheria coli DNA Polymerase V, a

Sloppier Copier. Myron F. Goodman,

Professor, Dept. of Biological Sciences,

USC. Lecture. 305 Weiss. Contact Terry

Chin, 327-7252.

12 p.m. Approaches to Study

Functional Gene Expression in

Psoriasis. James G. Krueger, Associate

Professor, RU. Seminar in Clinical

Research. 110B Nurses Residence.

12 p.m. Direct Measurement of T Cell

Kinetics in Humans Using a Stable

Isotope-mass Spectrometric

Technique: Effects of HIV-1 Infection

and Antiretroviral Therapy. Marc

Hellerstein, UC Berkeley. CFAR Seminar.

6th Floor Conference Room, ADARC,

455 First Ave.


12 p.m. Anabolic Androgenic Steroid

Effects on Brain and Behavior. Marilyn

Y. McGinnis, Professor, Dept. of Cell

Biology and Anatomy, Mount Sinai

School of Medicine. Endocrinology and

Reproductive Biology Seminar. 301


12 p.m. Protein NMR in the Post-

genomic Era. David A. Cowburn,

Associate Professor, RU. Biochemistry

Lecture. E-115 WMCCU, 1300 York


4 p.m. Ligament Fibroblast Response

to Cyclic Tensile Load in Vitro. Jo

Hannafin, HSS. “From Molecules to

Mobility” Research Division Seminar.

2nd Floor Conference Room B, HSS,

535 E. 70th St. Tea 5 p.m.


12 p.m. Role of Transcription Factors

in Blood Cell Commitment. Thomas

Graf, Professor, Albert Einstein College

of Medicine. Molecular Biology Seminar.

116 Rockefeller Research

Laboratories, MSKCC, 430 East 

67th St.

12 p.m. KSHV/HHV-8 in Human

Malignancies. Ethel, Cesarman,

Assistant Professor of Pathology, Dept. of

Pathology, WMCCU. Immunology

Seminar. 117 Whitney, WMCCU, 1300

York Avenue. Contact Michele Lavarde,



4 p.m. NMR Studies of T-Cell Protein

Interactions, Gerhard Wagner, Dept. of

Biological Chemistry and  Molecular

Pharmacology, Harvard School of

Medicine. NMR Structural Biology

Seminar. 301 Weiss.


4 p.m. From Single to Many Molecular

Motors. Frank Julicher, Institut Curie,

Paris. Center for Studies in Physics and

Biology Seminar. B Level Conference

Room, Smith Hall Annex. Tea, 3:30

p.m. Contact Matthew Turner, 327-8184.

4 p.m. Agonist Gating and Isoflurane

Potentiation in the Human GABAA

Receptor Determined by Volume of a

TM2 Residue. Neil Harrison, Associate

Professor, Dept. of Anesthesia and

Critical Care, U. of Chicago.

Pharmacology Seminar. Weill

Auditorium, WMCCU, 1300 York Ave.


4 p.m. Foreign DNA in Mammalian

Systems. Walter Doerfler, Professor of

Genetics, Institute of Genetics, U. of

Cologne. Pharmacology Seminar. Weill

Auditorium, WMCCU, 1300 York Ave.

5:30 p.m. The Future of Biomedical

Science—What We Will be Able to Do

and What We Will be Allowed to Do.

Daniel E. Koshland, Professor of

Biochemistry and Molecular Biology, UC

Berkeley; Former Editor, Science

Magazine. Zanvil A. Cohn Forum on

Health Affairs. Abby Aldrich

Rockefeller Dining Room. Sherry, 5

p.m., Abby Aldrich Rockefeller Lounge.

Contact Gloria Phipps, 327-8967.


12 p.m.

T Cells: Distinguishing

Young from Old. Adrian C. Hayday,

Professor of Immunobiology, Peter Gorer

Dept. of Immunobiology, Guy’s Hospital,

London. Immunology Seminar. A-250,

WMCCU, 1300 York Avenue. Contact

Michele Lavarde, 746-6452.


11 a.m. Gene, Peptide and Circadian

Behavior—Lessons from

Misexpressing Neuropeptide Pigment-

dispersing Factor in Drosophila

melanogaster. Marcus Taeuber, U. of

Regensburg, Germany. Lecture. 305


6:30 p.m. – 9 p.m. Breast Cancer

Diagnosis and Treatment at the

Millennium. Seminar. Uris

Auditorium, WMCCU, 1300 York Ave.

Contact, Marcelle Kaplan, 746-4708.

Seating available for 250 people on a first

come, first served basis.


4 p.m. 0-1 Laws for Single Molecules.

Bud Mishra, Courant Institute, NYU.

Center for Studies in Physics and Biology

Seminar. B Level Conference Room,

Smith Hall Annex. Tea, 3:30 p.m.

Contact Matthew Turner, 327-8184.

4 p.m. Recent Advances in Nutrition

and Cancer Prevention. Richard S.

Rivlin, Program Director, CNRU, GI-

Nutrition Service, MSKCC; Professor of

Medicine, WMCCU; Chief, Nutrition

Division, NYPH. CNRU Monthly

Meeting. 103 Rockefeller Research

Laboratories, 430 E. 67th St.


12 p.m. Inhibitors of 11-Beta-hydrox-

ysteroid Dehydrogenase. David J.

Morris, Professor, Department of

Pathology and Laboratory Medicine,

Brown U. Endocrinology and

Reproductive Biology Seminar. 301


3:45 p.m. From Discovery to the

Clinic: The Bryostatins. George R.

Pettit, Director of the Cancer Research

Institute, Regents Professor of Chemistry

and Dalton Professor of Cancer Research

and Medicinal Chemistry. Seminar.

Auditorium, Rockefeller Research

Laboratories, 430 E. 67th St. Tea, 

3:15 p.m.


12 p.m. Recursive Splicing and

Developmental Regulation of Splice

Site Choice in Drosophila. Antonio-

Javier Lopeza, Associate Professor, Dept.

of Biological Sciences, Carnegie Mellon

U. 116 Rockefeller Research

Laboratories, 430 E. 67th St.

12 p.m. CD 40 Signaling through

TRAF Proteins: Biochemical

Mechanisms & the Maintenance of

Receptor Signaling Specificity. Marilyn

R. Kehry, Distinguished Scientist, Dept.

of Biology, Boehringer Ingelheim

Pharmaceuticals. Immunology Seminar.

117 Whitney, WMCCU, 1300 York

Avenue. Contact Michele Lavarde, 746-



8 p.m. Peggy Rockefeller Concerts.

Petra Lang, mezzo-soprano, and Dennis

Helmrich, pianist, performing works by

Reger, Schumann, Wagner  and Strauss.

Caspary Auditorium. Contact Cathy

Rogers, 327-8437.

17 13


Molecular Analysis of Aging. Leonard

Guarente, Professor of Biology, MIT.


Structural Features of Antigen

Presentation. John W. Kappler,

Member, Dept. of Medicine, National

Jewish Medical and Research Center,

and Professor of Immunology and of

Medicine, U. of Colorado Health

Sciences Center, Denver; Investigator,



Structure and Function of

Prokaryotic RNA Polymerases. Seth

Darst, Associate Professor, RU.


Mechanisms of pre-mRNA Splicing.

Magda Konarska, Associate Professor,


These events are held in Caspary Auditorium at

3:45 P.M. Tea is served in Abby Aldrich

Rockefeller Lounge at 3:15 P.M. All are


The Calendar of Events is published Fridays

throughout the academic year. Deadline for 

submitting events is 2:00 P.M. Tuesday. Events

submitted by the Tuesday two weeks before the

event will be announced in two consecutive

calendars—space permitting.

To subscribe to the Calendar of Events mailing list,

send e-mail to Macjordomo@comm.rockefeller.edu


body of the message.






Friday Lecture s


h t t p : / / w w w. ro c k e f e l l e r. e d u / ru c a l


The Arts and

Other Events

Yüklə 194,94 Kb.

Dostları ilə paylaş:

Verilənlər bazası müəlliflik hüququ ilə müdafiə olunur ©azkurs.org 2022
rəhbərliyinə müraciət

    Ana səhifə