Warkentin, NEJM ’95, 11/332 SQ heparin v. 0/333 LMWH developed HIT
Laster, 1988, 10/2,000 (0.5%) HIT exposed only to coated vascular catheter
Frequency of thromboemboli – 30-75%
Some Paradoxes of HIT
Heparin, the most powerful anticoagulant of the twentieth Century, saving uncountable lives and limbs, also produces the most extreme hypercoagulable disorder, costing thousands yearly their lives and limbs.
it causes thromboses,(and platelet transfusions are contraindicated).
Health professionals should be knowledgeable about a reaction that is common, often catastrophic, preventable, treatable, iatrogenic, and a major source of litigation,yet textbooks and medical curriculae pay little attention,