$60,000 Small business grant awarded to Oregons Wild harvest to compare drying methods in herbs.
Pilot project on an NCCAM grant
$30, 000 to identify active constituents of Centella asiatica with respect to its role in Alzheimers disease
A Soumyanath PI; 20% effort
B Gold Co-Investigator
$25, 000 to identify active constituents of Centella asiatica with respect to its role in Alzheimers disease
A Soumyanath PI; 20% effort
B Gold Co-Investigator
$ 400,000 R21 GCRC supported clinical study on Centella asiatica triterpene extract in diabetic neuropathy.
Jau-Shin Lou PI, A Soumyanath, Co-I; 15% effort. I was the main author of this grant application.
$20,000 to study the effect of piperine in models of human reconstructed skin
$50,000 to study the effect of piperine in a mouse model of melanoma
$20,000 to develop methods to analyze bacopa saponins in human biological fluids*
*the samples were collected at NCNM
$275, 863 over 2 years. Re-entry into biomedical research careers supplement for A. Soumyanath (60% effort) awarded to the OADC.
5 year R01 ($1,620,913) to study “Mechanisms and active compounds in the cognitive effects of Centella asiatica”. A Soumyanath PI.
NIA – National Institute on Aging; NIH – National Institutes of Health; NCCAM – National Center for Complementary and Alternative Medicine; NCNM – National College of Naturopathic Medicine; OADC – Oregon Alzheimers Disease Center (OHSU internal funding); OPAR – Oregon Partnership for Alzheimer’s Research;
OCTRI – Oregon clinical translational research institute
Grants awarded since 1990 while at King’s College Londonare listed in the Table below. As the award system is different in the United Kingdom, i.e. there is no requirement to include a salary element for the applicant, or state a percent involvement, I have not given these figures. In each case, I was the principal investigator who was responsible for obtaining the grant and supervision of the project.
European Commission Marie Curie Fellowship for Regine Donaux; Diabetic retinopathy
Stiefel International – equipment grant.
Sabinsa/Sami Corporation contract work
Total grants raised (GB £)
V/6 Publications/Creative Work: Peer-reviewed full papers
(* indicates main author and/or PI of project)
Gray NE, MorréJ, Kelley J, MaierC, StevensJF, Quinn JF, Soumyanath A. Caffeoylquinic acids in Centella asiatica protect against β-amyloid toxicity (2014). J.Alzheimer’s Dis .40, 359–373.
Soumyanath A*, Zhong YP, Henson E, Wadsworth T, Bishop J, Gold B and Quinn JF (2012). Centella asiatica extract improves behavioral deficits in a mouse model of Alzheimer’s disease: investigation of a possible mechanism of action. International Journal of Alzheimer's Disease, Article ID 381974, 9 pages; doi:10.1155/2012/381974
Elsas S-M*, Rossi DJ, Raber J, White G, Seeley C-A, Gregory WL, Mohr C, Pfankuch T, Soumyanath A (2010). Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method. Phytomedicine, published online April 10, 2010.
FaasL, Venkatasamy, R, Hider RC, Young AR and Soumyanath A* (2008). In vivo evaluation of piperine and synthetic analogs as potential treatments for vitiligo using a sparsely pigmented mouse model, British Journal of Dermatology, 158, 941-950.
Zwickey H*, Brush J, Iacullo CM, Connelly E, Gregory WL, Soumyanath A, Buresh R (2007). The effect of Echinacea purpurea, Astragalus membranaceus, and Glycyrrhiza glabra on CD25 expression in humans: a pilot study Phytotherapy Research, 21(11), 1109-1112.
Lin ZX, Liao Y, Venkatasamy R, Hider RC and Soumyanath A* (2007). Amides from Piper nigrum L. with dissimilar effects on melanocyte proliferation in vitro. Journal of Pharmacy and Pharmacology, 59, 529-536.
Soumyanath A*, Venkatasamy R, Joshi M, Faas L, Adejuyigbe B, Drake A, Hider RC , Young AR (2006). UV Irradiation Affects Melanocyte Stimulatory Activity and Protein Binding of Piperine. Photochemistry and Photobiology, 82, 1541-1548.
Ali H, Houghton PJ*, Soumyanath A* (2006). a-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. Journal of Ethnopharmacology, 107, 449-455.
Brush J, MendenhallE, GuggenheimA, ChanT, Connelly E, Buresh R, SoumyanathA, ZwickeyH* (2006). The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. Phytother. Res., 20(8), 687-695.
Soumyanath A, Zhong Y-P, Gold S, Yu X, Koop DR, Bourdette, D, Gold BG* (2005). Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in vitro. Journal of Pharmacy and Pharmacology, 57, 1221-1229.
Itharat A, Houghton PJ*, Eno-Amooquaye E, Burke PJ, Sampson JH, Raman A (2004). In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer. Journal of Ethnopharmacology 90 (1), 33-38.
Venkatasamy R, Faas L, Young AR, Raman A*, Hider RC (2004). Effects of piperine and analogues on stimulation of melanocyte proliferation and melanocyte differentiation. Bioorganic and Medicinal Chemistry, 12(8), 1905-1920.
Goel RK*, Sairam K, Babu MD, Tavares IA, Raman A (2003). In vitro evaluation of Bacopa monniera on anti-Helicobacter pylori activity and accumulation of prostaglandins. Phytomedicine, 10 (6-7): 523-527.
Al-Habori M, Raman A*, Lawrence MJ and Skett P* (2001). Effect of fenugreek extracts on intestinal sodium dependent glucose uptake and hepatic glycogen metabolism in vitro. International Journal of Experimental Diabetes Research, 2, 91-99.
Sampson JH, Karlsen G, Navsaria H, Leigh IM and Raman A* (2001). In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. Phytomedicine, 8(3), 230-235.
Forte JS and Raman A* (2000) Regulatory issues relating to herbal products. Part 1: Legislation in the European Union, North America and Australia. Journal of Medicinal Food, 3(1), 23–40.
Forte JS and Raman A* (2000) Regulatory issues relating to herbal products. Part 2: Safety and Toxicity. . Journal of Medicinal Food, 3(1), 41–58.
Forte JS and Raman A* (2000) Regulatory issues relating to herbal products Part 3: Quality and its determination. . Journal of Medicinal Food, 3(1), 59-70
Srijayanta S, Raman A* and Goodwin BL (1999). A comparative study of the constituents of Aesculus hippocastanum and Aesculus indica. Journal of Medicinal Food, 2(2), 45–50.
Odukoya OA, Houghton PJ* and Raman A (1999). Lipoxygenase inhibitors in the seeds of Aframomum danielli K. Schum (Zingiberaceae). Phytomedicine, 6(4), 251-256.
Persaud SJ*, Al-Majed H, Raman A* and Jones PM (1999). Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. Journal of Endocrinology, 163 (2) 207-212.
Vedavanam K, Srijayanta S, O’Reilly J, Raman A* and Wiseman H* (1999). Anti-oxidant action and potential anti-diabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE). Phytotherapy Research, 13, 601-608.
Lin ZX, Hoult JRS, Bennett DC and Raman A* (1999). Stimulation of mouse melanocyte proliferation by Piper nigrum L. fruit extract and its main alkaloid piperine. Planta Medica, 65 (7), 600-603.
Mat Ali R, Houghton PJ*, Raman A and Hoult JRS (1999). Lipoxygenase inhibitors from Bignoniaceae plants in Malaysia. Journal of Tropical Forest Products, 5(1), 71-79.
Lin ZX, Hoult JRS and Raman A* (1999). Sulphorhodamine B for measuring proliferation of a pigmented melanocyte cell line and its application to the evaluation of herbs used in the treatment of vitiligo. Journal of Ethnopharmacology, 66 (2), 141-150.
AL-Habori M and Raman A* (1998). Review: Antidiabetic and hypocholesterolaemic effects of fenugreek. Phytotherapy Research 12 233-242.
Raman A* and Croom EM Jr. (1998). The anatomical features of Ginkgo biloba L. leaf as observed by light microscopy. Journal of Medicinal Food 1(2) 89-95.
Mat Ali R, Houghton PJ*, Raman A and Hoult JRS (1998). Antimicrobial and anti-inflammatory activities of extracts and constituents of Oroxylum indicum (L.) Vent. Phytomedicine 5(5) 375-381.
Raman A* and Jamal JA (1997). "Herbal hayfever remedy found to contain conventional drugs". The Pharmaceutical Journal 258 105-106.
Raman A*, Lansley AB and Greene RJ (1997). Topic Weeks - Delivery of integrated pharmacy teaching to undergraduates. The Pharmaceutical Journal 259 563-565.
Raman A* and Lau C (1996). Anti-diabetic properties and phytochemistry of Momordica charantia L.(Cucurbitaceae). Phytomedicine 2(4) 349-362.
Lau C, Raman A*, Noel M, Kergoat M, Lawrence MJ and Dodoo ANO (1996). Evidence for glucose transport inhibitors in Momordica charantia L. Diabetologia, 39 (S1) A171.
Raman A*, Lin ZX, Sviderskaya E and Kowalska D (1996). Investigation of the effect of Angelica sinensis root extract on the proliferation of melanocytes in culture. Journal of Ethnopharmacology 54 165-170.
Raman A*, Weir U and Bloomfield SF (1995). Antimicrobial effects of tea-tree oil and its major components on Staphylococcus aureus, Staph. epidermidis and Propionibacterium acnes. Letters in Applied Microbiology 21 242-245.
Anjum F, Raman A*, Shakoori AR and Gorrod JW (1993). Effects of sublethal doses of cadmium chloride on native and phenobarbitone induced drug metabolising enzymes in male rabbits. Pharmaceutical Science Communications 4 45-49.
Anjum F, Raman A*, Shakoori AR and Gorrod JW (1992). An assessment of cadmium toxicity on cytochrome P-450 and flavin monooxygenase-mediated metabolic pathways of dimethylaniline in male rabbits. Journal of Environmental Pathology, Toxicology and Oncology 11 (4) 191-195.
Akunyili DN, Houghton PJ* and Raman A (1991). Antimicrobial activities of the stembark of Kigelia pinnata. Journal of Ethnopharmacology 35 173-177.
Raman A* and Gorrod JW (1991). The metabolic interconversion of O-methylbenzophenone oxime isomers. Progress in Pharmacology and Clinical Pharmacology 8(3) 203-217.
Gorrod JW and Raman A* (1989). Imines as intermediates in oxidative aralkylamine metabolism. Drug Metabolism Reviews 20 307-339.
Raman A*, Christou M and Gorrod JW (1987). Primary aliphatic amine metabolism: the formation of a stable imine metabolite. European Journal of Drug Metabolism and Pharmacokinetics 12(4) 279-283.
Published research abstracts – these were all peer-reviewed prior to acceptance
(* indicates main author and/or supervisor of project)
Samatham,R.; Phillips,K.G.; Sonka,J.; Yelma,A.; Reddy,N.; Vanka,M.; Thuillier,P.; Soumyanath,A.; Jacques,S. Monitoring human melanocytic cell responses to piperine using multispectral imaging. Progr. Biomed. Opt. Imaging Proc. SPIE, 2011, 7883, San Francisco, CA
Soumyanath A, Zhong Y-P, Gold S, Yu X, Koop DR, Bourdette, D, Gold BG* (2005). Centella asiatica accelerates nerve regeneration in rat sciatic nerve upon oral administration and increases neurite elongation via ERK activation. Journal of the Peripheral Nervous System, 10, 27-28.
Soumyanath A, Zhong Y-P, Gold S, Yu X, Koop DR, Bourdette, D, Gold BG* (2005). Centella asiatica (Gotu kola) increases neurite elongation via ERK activation and is orally active in speeding nerve regeneration in the rat sciatic nerve crush model. Neurology, 64(6): A407-A407. Suppl 1.
Ali H, Raman A* and Houghton PJ* (2003). a-Amylase inhibition in Malayasian local plants. Journal of Pharmacy and Pharmacology, 55(Supplement): S28.
Chronnell CMT, Raman A*, Forbes B and Houghton PJ* (2003). Medicinal plants as potential new treatments for psoriasis. Journal of Pharmacy and Pharmacology, 55(Supplement): S30.
Bawden K, Quant J, Ali F, Raman A* and Houghton PJ* (2003). Fractionation and characterization of compounds inhibiting a-amylase and their potential as anti-diabetic remedies. Journal of Pharmacy and Pharmacology, 55(Supplement): S31.
Ali H, Raman A* and Houghton PJ* (2003). α-Amylase inhibition in Malaysian local plants. Journal of Pharmacy and Pharmacology, 55(Supplement): S31.
Bawden K, Quant J, Ali F and Raman A* and Houghton PJ* (2003). Fractionation and characterization of compounds inhibiting α-amylase and their potential as anti-diabetic remedies. Journal of Pharmacy and Pharmacology, 55(Supplement): S34.
Chronnell CMT, Raman A*, Forbes B and Houghton PJ* (2003). Medicinal plants as potential new treatments for psoriasis. Journal of Pharmacy and Pharmacology, 55(Supplement): S33.
Pires M, and Raman A* (2002). Isolation of a keratinocyte proliferation inhibitor from Vernonia anthelmintica (Willd.) seeds traditionally used for psoriasis. Journal of Pharmacy and Pharmacology, 54 (Suppl.): S6.
Pires M, Hoult JRS and Raman A* (2002). Anti-inflammatory activity of Vernonia anthelmintica (L) Willd seed extracts. Journal of Pharmacy and Pharmacology, 54 (Suppl.), S80.
Bawden K, Quant J, Raman A* (2002). An Investigation of the inhibitory effects of plant extracts on a starch-alpha-amylase assay. Journal of Pharmacy and Pharmacology, 54 (Suppl).: S80.
Pires M, Schlosser S, Waterfield CJ, Sampson J, Che CT and Raman A* (1999). Development and application of an in vitro bioassay for plant derived antipsoriatic agents using SVK-14 keratinocytes. Journal of Pharmacy and Pharmacology, 51(S), 96.
Srijayanta S, Jones PM, Persaud S, Hoult JRS and Raman A* (1999). Mangiferin, and antidiabetic compound from Anemarrhena asphodeloides. Journal of Pharmacy and Pharmacology, 51(S), 98.
Lau C, Raman A*, Noel M, Kergoat M and Autier V (1998). Phytochemicals isolated from the anti-hyperglycaemic extract of the unripe fruit of Momordica charantia L. Journal of Pharmacy and Pharmacology 50(S) 84.
Lin Z, Donatien P, Raman A* and Bennett DC (1998). A naturally occurring growth promoter for human melanoblasts in culture. Journal of Pharmacy and Pharmacology 50(S) 218.
Raman A*, Lin Z and Hoult JRS (1998). Identification of a phytochemical stimulant for the proliferation of mouse melanocytes in culture. Journal of Pharmacy and Pharmacology 50(S) 247.
Srijayanta S, Jones PM, Persaud S, Lawrence MJ and Raman A* (1998). In-vitro screening of medicinal plants for potential anti-diabetic effects. Journal of Pharmacy and Pharmacology 50(S) 219.
Lin Z, Raman A*, Kim DSHL (1997). Betulinic acid and betulin at up to 10mM concentration have no inhibitory effects on melan-a cell line. Journal of Pharmacy and Pharmacology 49 (S4) 35.
Raman A*, Donaux NM, Herpin M and Jayan A (1997). Comparison of Phytosol extraction with conventional methods of extracting the volatile oil from Clove (Syzygium aromaticum) and Wild oregano (Coleus aromaticus). Journal of Pharmacy and Pharmacology 49 (S4) 112.
Srijayanta S, Raman A* and Goodwin B (1997). A comparative study of Aesculus hippocastanum and Aesculus indica. Journal of Pharmacy and Pharmacology 49 (S4) 111, 1997.
Persaud SJ*, Redmond EMT, Raman A*, Bone AJ and Jones PM (1996). Stimulation of insulin secretion by Gymnema sylvestre: investigation of mode of action. Diabetic Medicine 13 S22.
Raman A* and Mallam V (1994). Enhanced in vitro activity of glucokinase enzyme in the presence of extracts of Hunteria umbellata seeds, a traditional Nigerian treatment for diabetes. Journal of Pharmacy and Pharmacology 46 1046.
Raman A*, Baptist OT, Hunt G and Thody A (1993). Effect of Psoralea corylifolia L, Polygonum multiflorum Thunb. and Ligustrum lucidum Ait. on melanin production and cell number in B16 F1 mouse melanoma cell cultures. Journal of Pharmacy and Pharmacology 45 1101.
Mutambo F, Raman A* and Theobald AE (1991). Isolation and purification of trypsin inhibitors from Pumpkin seeds (Cucurbita maxima). Journal of Pharmacy and Pharmacology 43 (S) 124P.
Raman A and Houghton PJ (1995). Herbal products: 8.Ginseng. Pharmaceutical Journal 254 150-152.
Peter J Houghton and Amala Raman. Laboratory Handbook for the Fractionation of Natural Extracts, 1998. Publ. Chapman and Hall, London, pp. vi +199. ISBN 0 412749106
Amala Soumyanath (Editor). Traditional Herbal Medicines for Modern Times – Anti-diabetic plants. Publishers Taylor and Francis (CRC Press). In press, publication date October 2005.
Soumyanath A* (2003). “Botanicals: preparations, uses, quality issues and interactions” in Complementary and Alternative Therapies in Neurological Disorders. Ed. B. Oken. Publ. Taylor and Francis, UK, pp 7-22.
Al-Habori M and Raman A (2002). “Pharmacological properties of fenugreek” in Trigonella - Industrial profiles of medicinal and aromatic plants. Ed G. Petropoulos. Publ. Harwood Academic Publishers, Amsterdam, The Netherlands.
Raman A* (1998). “The Cannabis Plant: botany, cultivation and processing for use” in Cannabis - Industrial profiles of medicinal and aromatic plants. Ed David Brown. Publ. Harwood Academic Publishers, Amsterdam, The Netherlands, pp. 29-54.
Raman A* and Joshi AN (1998). “The Chemistry of Cannabis” in Cannabis - Industrial profiles of medicinal and aromatic plants. Ed David Brown. Publ. Harwood Academic Publishers, Amsterdam, The Netherlands, pp. 55-70.
Raman A* and Lin ZX (1996). “Screening plant extracts for the treatment of vitiligo” in Conference Proceedings. Active Ingredients, Palais De Congres de Paris, Nov 13-14, 1996. Ed. H. Ziolkowsky. Publ. Verlag für chemische Industrie, Augsburg, GmBH, pp. 203-211. (ISBN 3-87846-183-6).
Raman A* and Skett P (1998). “Traditional remedies and diabetes treatment” in Plants for food and medicine. Eds. HDV Prendergast, NL Elkin, DR Harris and PJ Houghton. Publ. Royal Botanic Gardens, Kew, UK, pp. 361-372.
Akunyili DN, Houghton PJ and Raman A (1991). "Chemical basis for the traditional uses of Kigelia pinnata in Ethnopharmacology: sources, methods, objectives. Eds. J Fleurentin, P Cabalion, G Mazars, J dos Santos and C Younos. Publ. ORSTOM, Paris, pp 339 - 340.
Gorrod JW and Raman A* (1989). "The role of drug metabolism in initiating drug toxicity" in Molecular aspects of human disease. Eds JW Gorrod, O Albano and S Papa. Publ. Ellis Horwood, pp 47-67.
Raman A* and Wisneski A* (2001). Chaste Tree Fruit, Vitex agnus-castus - Therapeutics (pg 13-31). Section in the American Herbal Pharmacopoeia monograph on Chaste Tree Fruit, Vitex agnus-castus. Ed Roy Upton. Publ. American Herbal Pharmacopoeia, Santa Cruz, California.
VI. SERVICE Membership of Professional Bodies:
MRPharmS - Member of the Royal Pharmaceutical Society of Great Britain (1982 - 2004)
Membership of Societies:
Phytochemical Society of Europe (to 2002)
American Society of Pharmacognosy (current)
UK Association of Pharmaceutical Scientists ( to 2002)
Pharmaceutical Sciences Group of the Royal Pharmaceutical Society of Great Britain ( to 2002)
Granting Agency Review Work:
Have reviewed grants for
The Wellcome Trust, United Kingdom
The International Science Federation
Editorial and Ad Hoc Review Activities:
Reviews Editor for Phytotherapy Research (1998 – 2002), handling 8 review articles per year. Successfully achieved the target of 1 review/issue. Reviewer of scientific research papers for Journal of Ethnopharmacology, International Journal of Pharmacognosy, Journal of Natural Products, Journal of Herbs, Spices and Medicinal Plants, Phytotherapy Research, Journal of Pharmacy and Pharmacology.
OHSU Conflict of Interest in Research Committee (February 2014 – present)
Membership of United States Pharmacopiea Advisory Panel on Standards for Dietary Supplements and Natural Products ( to 2004)
Member of the scientific advisory panel for the Medical Cannabis Research Foundation (UK) (to 2002)
Member of the Traditional Medicines Evaluation Committee (London) (to October 2002)
Member of the School of Health and Life Sciences Postgraduate Research Training Committee (1997 – 2000).
Trustee of the Vitiligo Society, United Kingdom (1997 – 2002). The Vitiligo Society is a charity (not for profit organization) whose mission is to help those affected by the skin disease vitiligo.
Volunteer at Rieke Elementary School (2010 – 2011)
VII. REFEREES: 1) Professor Peter J Houghton,
2) Roy Thomas Upton, RH, DAyu
Executive Director, American Herbal Pharmacopoeia
General Manager, Planetary Formulas
3051 Brown's Lane
Soquel, CA 95073 US
3) Heather Zwickey, PhD
Dean of Research
National College of Natural Medicine
Director of Research
Helfgott Research Institute
049 SW Porter Street
Portland, OR 97201