L. Buttler,
M.T. Jordão and L.C. Michelini. Univ. of São Paulo.
B174
1121.8 Low-dose cadmium exposure upregulates
glutathione (GSH) synthesis in cultured choroid plexus.
A.
Villalobos, R. Young and S. Francis Stuart. Texas A&M Univ.
1122. BRAIN DEVELOPMENT AND AGING
Poster
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B175
1122.1 Lactational DEHP exposure-impaired motor
coordination and motor skill learning in adolescent rats.
S-C.
Yueh, R-C. Yang and D-C. Wang. Kaohsiung Med. Univ.,
Taiwan.
B176
1122.2 Microglia display distinct sex-dependent
gene expression profiles in the postnatal and adult CNS.
M.
Nikodemova, J. Crain and J.J. Watters. Univ. of Wisconsin-
Madison.
1123. CENTRAL REGULATION OF FOOD INTAKE AND
BODY WEIGHT
Poster
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B177
1123.1 Control of feeding behavior by CRH 2
receptors in the paraventricular nucleus of the hypothalamus of
adrenalectomized rats.
M. Rito-Domingo, V.E. López Alonso,
K.A. Reyes Santos, G. Ambrocio Segundo, K. Cruz García
and J.M. Mancilla Díaz. Natl. Autonomous Univ. of Mexico.
B178
1123.2 Nesfatin-1 does not influence intracellular
calcium concentrations in neurons of the nucleus of the
solitary tract or the paraventricular nucleus.
A. Mimee and A.V.
Ferguson. Queen’s Univ., Canada.
B179
1123.3 Nesfatin-1 influences the excitability of
subfornical organ neurons.
M.A. Kuksis, L. Dai and A.V.
Ferguson. Queen’s Univ., Canada.
B180
1123.4 Intrauterine undernutrition programs the
hypothalamic proteome of female rats.
E.B. Ribeiro, A.P.
Pedroso, A.P. Souza, A.P.S. Dornellas, D. Estadella, C.M.O.
Nascimento, L.M. Oyama, J.C. Rosa and R.L.H. Watanabe.
Fed. Univ. of São Paulo.
B181
1123.5 Subfornical organ: a novel site for the actions
of cholecystokinin.
A-S.F. Ahmed, A.V. Ferguson and K.A.
Sharkey. Univ. of Calgary and Queen’s Univ., Canada.
B182
1123.6 A monoclonal antibody targetting the FGFR-
1c isoform reduces body weight and food intake, which
is, associated with a suppression of deiodinase 2 mRNA
expression in hypothalamic tanycytes.
R. Samms, A. Lory, J.
Roberts, A. Warner, S. Sundquis, P. Emmerson, B. Perry, K.
Tsintzas and F. Ebling. Univ. of Nottingham, Karolinska Inst.,
Eli Lilly and Univ. of Aberdeen.
B183
1123.7 Photic stimulation is required to elicit estrogen-
induced anorexia in rats.
K. Mabuchi, A. Takano, Y. Hara, K.
Morimoto and A. Takamata. Nara Women’s Univ, Japan.
B184
1123.8 Insulin and glucose stimulation of vasopressin
and oxytocin release requires glucokinase and PI3 kinase.
C.D.
Sladek, Z. Song and W. Stevens. Univ. of Colorado Sch. of
Med.
B185
1123.9 Taste without calories is insufficient to drive
conditioned flavor preferences.
J.M. Stratford and T.E. Finger.
Univ. Colorado Denver Anschutz Med. Campus.
B186
1123.10 Orchiectomy increases food intake and
perifornical orexin A neuron’s activity during glucoprivation.
A.
Takamata, K. Miyake, K. Mabuchi and K. Morimoto. Nara
Women’s Univ, Japan.
B187
1123.11 Insulin-induced increase in intracellular
calcium in the supraoptic nucleus neurons requires activation
of PI3 kinase.
Z. Song, W. Stevens and C.D. Sladek. Univ. of
Colorado Sch. of Med.
B188
1123.12 Hypophysectomy attenuates leptin-induced
tachycardia without affecting leptin’s action on appetite and
body weight.
A.A. da Silva, Z. Wang, J.E. Hall and J.M. do
Carmo. Univ. of Mississippi Med. Ctr.
B189
1123.13 Adiponectin receptor mediated weight
regulation: an inflammation-independent mechanism?
Z.A.P.
Wintrob, H. Radpasand, M.H. Elmeshad, A. Barima, J.L.
Rabey, K.A. Chmiel, Z.S. Fayazi, L. Otvos, E. Surmacz, S.
Faitar and A.C. Ceacareanu. Univ. at Buffalo, D’Youville Col.,
NY and Temple Univ. and Sbarro Inst. for Cancer Res.
TUESDAY PHYSIOLOGY
388
1124. COGNITION AND BEHAVIOR
Poster
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B190
1124.1 Correlation and causation: systems level
understanding of decision-making signals at the single-neuronal
level in the human brain.
S.R. Patel, S. Sheth, M. Mian, S.
Bourne, A. Flaherty and E. Eskandar. Massachusetts Gen.
Hosp.
B191
1124.2 Avoidance of environmental gas irritants
mediated by TRPA1.
T. Yonemitsu, N. Takahashi, Y. Mori,
Y. Kanmura and T. Kuwaki. Grad. Sch. of Med. Dent. Sci.
Kagoshima Univ. and Grad. Sch. of Engin., Kyoto Univ.
B192
1124.3 Less exercise, more effects: enhancement
of cognitive functions associated with hippocampal BDNF
signaling by voluntary resistance wheel running in adult rats.
M.C. Lee, Y.F. Liu, K. Inoue, M. Okamoto and H. Soya. Inst.
for Hlth. and Sports Sci., Tsukuba, Japan.
B193
1124.4 Omega-3 fatty acid supplementation improves
adaptive coping in a rat model of post-partum depression.
E.M.
Gonzales, D.W. Barrett, F. Gonzalez-Lima and M.A. Lane.
Texas State Univ., San Marcos and Univ. of Texas at Austin.
B194
1124.5 Stress and immune function of social drinking
college students before and after spring break.
S. Sharma, K.
Howard, R. Graham and N. Ceballos. Texas State Univ.-San
Marcos.
B195
1124.6 Decreased neurogenesis in the dentate gyrus
following sensory non-normative overstimulation.
J.S.B.
Ramirez, D.A. Christakis, R.D. Hodge, R.F. Hevner, A.F.
Smith, T.K-M. Ramirez, M.F. Burgos and J.M. Ramirez.
Seattle Children’s Res. Inst., Univ. of Washington and Univ. of
Chicago.
B196
1124.7 Behavioral profile assessment in offspring
of Swiss mice underwent to neonatal treatment with
D-fenfluramine.
R.L. Melo, A.L.B. Silveira, F.A.C. Seara, F.F.
Rocha, L.C. Reis and W.S. Cortes. Fed. Rural Univ. of Rio de
Janeiro, Seropédica.
B197
1124.8 Behavioral profile assessment in offspring of
Swiss mice treated during pregnancy and lactation with caffeine.
A.L.B. Silveira, R.L. Melo, F.A.C. Seara, C.S. Almeida, F.F.
Rocha, A.S.N. Santos, B.G. Marinho, L.C. Reis and W.S.
Cortes. Fed. Rural Univ. of Rio de Janeiro, Seropédica.
B198
1124.9 Perinatal exposure to low levels of carbon
monoxide impairs neurobehavior in adult mice.
J.T. O’Neill,
M.L. Kehl, K.P. Johnson, K. Cravedi, E.S. Barry and N.E.
Grunberg. Uniformed Svcs. Univ. of Hlth. Sci.
B199
1124.10 Comparison of floor aerobics and treadmill
walking on cognitive changes and participant satisfaction.
J.
Larsen, C-L. Hansen, M. Schmitter-Edgecombe and J.
Knuth. Washington State Univ.
1125. PERIPHERAL CIRCULATION
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B200
1125.1 Heterogeneous vasodilator pathways
underlying flow mediated dilation are preserved in healthy
aging.
K.D. Ballard, M.E. Tschakovsky, A.L. Zaleski, D.M.
Polk, P.D. Thompson, F.J. Kiernan and B.A. Parker. Hartford
Hosp., CT, Sch. of Kinesiol. and Hlth. Studies, Queen’s Univ.,
Canada and Univ. of Hartford.
B201
1125.2 High dietary sodium reduces flow mediated
dilation similarly in humans with salt sensitive and salt resistant
blood pressure.
E.L. Matthews, J.J. DuPont, J.L. Greaney,
S.L. Lennon-Edwards, D.G. Edwards and W.B. Farquhar.
Univ. of Delaware.
B202
1125.3 Role of forearm vasoconstriction in the
development of primary Raynaud’s disease.
Z. Hussain, G.
Ball and J.E. Davis. Alma Col., MI.
B203
1125.4 Sensitivity of forearm critical power to acute
manipulation of perfusion pressure.
J. M. Kellawan, R.F.
Bentley, J.J. Walsh, J.S. Moynes and M.E. Tschakovsky.
Sch. of Kinesiol and Hlth. Studies, Queen’s Univ., Canada.
B204
1125.5 Contributions of cyclooxygenase and NO
synthase pathways to endothelium-dependent dilatation in the
finger of women.
J.M. Marshall. Univ. of Birmingham, U.K.
B205
1125.6 Individual vasodilatory response heterogeneity
during progressive forearm exercise: evidence for vasodilator
phenotypes.
R.F. Bentley, J.M. Kellawan, J.S. Moynes, V.J.
Poitras, J.J. Walsh and M.E. Tschakovsky. Sch. of Kinesiol.
and Hlth. Studies, Queen’s Univ., Canada.
B206
1125.7 Pro-atherogenic blood flow and shear patterns
acutely induce the release of CD62E
+
and CD31
+
/CD42b
-
endothelial microparticles in humans.
N.T. Jenkins, J. Padilla,
L. Boyle, D.P. Credeur, M.H. Laughlin and P.J. Fadel. Univ. of
Missouri-Columbia.
B207
1125.8 Carotid artery intima-media echogenicity and
aortic stiffness in healthy middle-aged and older humans.
K. Aizawa, S. Elyas, D.D. Adingupu, F. Casanova, K.M.
Gooding, D.M. Mawson, A.C. Shore, W.D. Strain and P.E.
Gates. Univ. of Exeter Med. Sch., U.K.
B208
1125.9 Lower potassium intake is associated with
increased wave reflection in young healthy males.
S. Lennon-
Edwards, T. Schellhardt, B. Allman, W.B. Farquhar and D.G.
Edwards. Univ. of Delaware.
B209
1125.10 Mitochondria-targeted antioxidant therapy
with MitoQ ameliorates age-related vascular endothelial
dysfunction.
R.A. Gioscia-Ryan, T.J. LaRocca, M.C. Zigler,
M.P. Murphy and D.R. Seals. Univ. of Colorado Boulder and
Univ. of Cambridge.
B210
1125.11 Model predictions of arterial adaptation to
steady-flow left ventricular assist devices.
P.H. Nguyen, E.
Tuzun, S.F. Knezek, M.W. Mohiuddin and C.M. Quick.
Michael E. DeBakey Inst. and Texas A&M Inst. for Preclin.
Studies.
PHYSIOLOGY TUESDAY
389
T
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1126. CARDIAC FUNCTION AND DYNAMICS I
Poster
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B211
1126.1 Is myocardial iron content associated
with left atrial systolic function in asymptomatic hereditary
hemochromatosis?
Y. Shizukuda, D. Tripodi, V. Sachdev, C.
Brenneman, S. Sidenko, M. St. Peter, C. Bolan, Y.Y. Yau, A.
Arai, P. Bandettini, S. Leitman and D. Rosing. NHLBI, NIH,
Univ. of Cincinnati and NIH Clin. Ctr.
B212
1126.2 Epicardial force and strain measurements from
the in vivo murine heart.
C. Constantinides, M. Michaelides
and S. Georgiadou. Univ. of Cyprus, Cyprus and Natl.
Reference Lab. for Animal Hlth., Cyprus.
B213
1126.3 Longitudinal assessment of systolic and
diastolic function using conventional and speckle tracking
echocardiography following acute ischemia and prolonged
reperfusion in the rat.
W. Bao, F. Wright, Z. Ao, R.C. Mirabile,
K.S. Frazier, R.W. Coatney, C.G. Schnackenberg and B.M.
Jucker. GlaxoSmithKline.
B214
1126.4 Measurement of heart function for myocardial
infarction model of rat by microCT.
S. Matsushita, M. Naito
and A. Amano. Juntendo Univ., Japan.
B215
1126.5 Cardiovascular response to an inhaled
b-agonist in patients with heart failure: effect of b-blockade.
M. Martinez, S.E. Baker, B. Taylor, B.D. Johnson and E.M.
Snyder. Univ. of Arizona, Mayo Clin. and Univ. of Minnesota,
Minneapolis.
B216
1126.6 Interaction of mitofilin with respiratory
complexes in mitochondrial subpopulations.
D. Thapa, R.
Jagannathan, T.L. Croston, W.A. Baseler, C.E. Nichols, D.L.
Shepherd, S.E. Lewis and J.M. Hollander. West Virginia Univ.
B217
1126.7 Age dependency of autonomic response to
recumbent positions.
R. Sato, K. Sasaki, M. Haga, H. Sato, Y.
Kimura, E. Kanno and R. Maruyama. Tohoku Univ. Grad. Sch.
of Med., Japan and Univ. of Tokyo Hosp.
B218
1126.8 A rat model of doxorubicin-induced late-onset
cardiotoxicity.
N.M. Gibson, C-Y. Lien, B.T. Jensen, D.S.
Hydock and R. Hayward. Univ. of Northern Colorado, Taiwan
Natl. Univ. and Slippery Rock Univ.
B219
1126.9 Endovascular dual-sensor composite sensor
catheter for the measurement of flow and pressure in rats using
telemetry.
K. Pitsillides, M. Lin, L. Griffiths, D. Uyeminami, K.
Johnson and K. Pinkerton. Transonic EndoGear Inc., Davis
and Univ. of California, Davis.
B220
1126.10 Oxidative stress level mediates the inotropic
effects of alcohol on the heart.
M. AlRubaiee, N. Umoh, M.
Jeffress, R. Walker, V. Cousins and G.E. Haddad. Howard
Univ.
B221
1126.11 Ursolic acid potentiates muscarinic receptor-
induced ANP secretion in perfused beating rat atria.
H.Y. Kim,
O.J. Kwon, J.H. Kho, R. Tan, K.W. Cho, D.G. Kang and H.S.
Lee. Wonkwang Univ., South Korea.
1127. ENDOTHELIAL CELL BIOLOGY III
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B222
1127.1 Protease-activated receptor-3 signals
independent of protease-activated receptor-1 to regulate
endothelial nitric oxide synthase in human endothelial cells.
L.C. Tillery and E. Motley-Johnson. Meharry Med. Col.
B223
1127.2 Sex differences in aortic endothelial function
of streptozotocin-induced diabetic rats: a possible role of
superoxide production.
X. Han, R. Zhang, L. Anderson and R.
Rahimian. Univ. of Pacific.
B224
1127.3 L-leucine inhibits nitric oxide synthesis in
endothelial cells.
Y. Yang, C. Meininger, K. Kelly, Z. Wu, F.
Bazer and G. Wu. Texas A&M Univ.
B225
1127.4 Physiologic cyclic strain stimulates heme
oxygenase-1 gene expression in endothelial cells: role in cell
survival and proliferation.
W. Durante, X-m. Liu and K.J.
Peyton. Univ. of Missouri-Columbia.
B226
1127.5
b-Arrestin-mediated signal transduction
participates in laminar shear stress-induced production of nitric
oxide in endothelial cells.
A.P.C. dos Santos, V.G. Barauna,
M.H.F. Alaniz, A.C.C. Girardi and J.E. Krieger. Univ. of São
Paulo Med. Sch.
B227
1127.6 Endothelial cells from different vascular bed
respond to secondhand smoke differently under dynamic shear
stress.
W. Yin, E.C. Ngwe and D.A. Rubenstein. Oklahoma
State Univ.
B228
1127.7 Disturbed flow increases caveolae-mediated
oxLDL uptake in endothelial cells.
E. LeMaster, S. Sun, V.
Shinin, D. Eddington, M. Cho, R. Minshall and I. Levitan.
Univ. of Illinois at Chicago.
B229
1127.8 20-HETE activates endothelial ACE via an IKK/
NF-
kB dependent pathway. V.G. Garcia, L. Milhau, J.R. Falck
and M.L. Schwartzman. New York Med. Col., Fac. of Pharm.,
Montpellier, France and Univ. of Texas Southwestern Med. Ctr.
B230
1127.9 Tachycardia promotes mitochondrial DNA
damage by JNK translocation to mitochondria.
N. Jen, R. Li
and T. Hsiai. Univ. of Southern California.
1128. INFLAMMATION AS AN ORCHESTRATOR IN
HEART FAILURE (POSTERS)
Poster
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B231
1128.1 The role of TNF-
a in cardioprotection induced
by adaptation to chronic hypoxia in rats.
J. Neckar, A. Chytilova,
G.H. Borchert and F. Kolar. Inst. of Physiol. Acad. of Sci. of
Czech Republic, Prague.
B232
1128.2 Thromboxane A2 mediates apoptosis in
cardiomyocytes via IP3.
C.D. Touchberry, C.J. Elmore, S.
Srinivas and M.J. Wacker. Sch. of Med., Univ. of Missouri-
Kansas City.
B233
1128.3 Gene expression profiling in the rat infarcted
heart in response to antioxidant treatment.
W. Zhao, T. Zhao,
Y. Chen, Y. Qu, I.C. Gerling, K.T. Weber and Y. Sun. Univ. of
Tennessee, Memphis.
TUESDAY PHYSIOLOGY
390
B234
1128.4 The protection of urocortin 2 against ischemia/
reperfusion injury is due to p38 MAPK downregulation in an
isolated rat heart model.
Y. Zhou, X. Gao, D. Wang, K. Lew,
A. Richards and P. Wang. Natl. Univ. of Singapore, Huashan
Hosp., Shanghai and Putuo Hosp., Shanghai.
B235
1128.5 Crosstalk between Toll-like receptor 4 and
interleukin 10 in cardiomyocyte survival.
A.K. Bagchi, A.
Sharma, G. Akolkar and P.K. Singal. St. Boniface Res. Ctr.,
Univ. of Manitoba.
B236
1128.6 CD40-CD40 ligand (CD40L) signaling
modulates cardiac hypertrophy in angiotensin-IIi induced
hypertensive heart disease.
W. Derks, E. Lutgens, M. van
Bilsen and S. Heymans. Maastricht Univ. and Acad. Med. Ctr.,
Amsterdam.
B237
1128.7 Thromboxane A2 mimetic, U46619, does not
induce markers of pathological hypertrophy in cardiomyocytes.
M.J. Wacker, V. Tchikrizov, H.K. Swan, L.A. Wetmore and
C.D. Touchberry. Sch. of Med., Univ. of Missouri-Kansas City
and William Jewell Col., MO.
B238
1128.8 Osteonectin protects against adverse cardiac
inflammation during viral myocarditis.
A. Papageorgiou,
M. Rienks, D. Vanhoutte, W. Verhesen, P. Carai, T.
Vandendriessche, M. Chuah and S. Heymans. Maastricht
Univ., Netherlands, Univ. Leuven, Belgium and Cincinnati
Children’s Hosp. Med. Ctr.
B239
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