Parthasarathy, V. Lgishetty, R. Lockey and N. Kolliputi. Univ.
of South Florida.
B482
1143.6 Caveolae regulate nitroxidative signaling via
localized nitration of Src-family kinase in endothelial cells.
H.
Singh and V. Rizzo. Temple Univ. Sch. of Med.
B483
1143.7 Resveratrol blunts the positive effects of
exercise training in aged men; a double-blind, randomized,
placebo-controlled training study.
L. Gliemann, M. Nyberg,
R.S. Biensø, N. Iversen, J. Olesen, S.P. Mortensen, J.F.
Schmidt, H. Pilegaard and Y. Hellsten. Univ. of Copenhagen
and Rigshospitalet.
B484
1143.8 Nitric oxide deficit elicits oxidative stress and
augments T-type calcium channel contribution to vascular tone.
C.E. Hill, I.Y. Kuo, A. Ellis, D.J. Chaston, H-S. Shin, P.B.
Hansen and L. Howitt. Australian Natl. Univ., Korea Inst. of
Sci. and Technol. and Univ. of Southern Denmark.
TUESDAY PHYSIOLOGY
400
B485
1143.9 N-acetylcysteine administration modulates
NADPH oxidase in skeletal muscle of rats with heart failure.
P.F. Martinez, D.C. Fernandes, C. Bonomo, M.D.M. Cezar,
S.A. Oliveira, Jr., L.A.M. Zornoff, K. Okoshi, F.R. Laurindo
and M.P. Okoshi. UNESP, Botucatu, InCor, São Paulo and
UFMS, Campo Grande, Brazil.
B486
1143.10 Correlation between cardiovascular autonomic
control dysfunction and oxidative stress in an experimental
model of hypertensive and menopause submitted to fructose
overload.
F.F. Conti, J.O. Brito, R.K. Palma, N. Bernardes, I.C.
Sanches, M.C. Irigoyen and K. De Angelis. Nove de Julho
Univ., Brazil and Univ. of São Paulo - Heart Inst.
B487
1143.11 Dependence of cytotoxicity of menadione and
cytoprotection by antioxidants in human endothelial cells on
oxygen levels: atmospheric oxygen versus physiological levels.
A. Rastogi, S. Stavchansky and P. Bowman. U.S. Army Inst.
of Surg. Res., Fort Sam Houston, The Geneva Fndn., Tacoma,
WA and Univ. of Texas at Austin.
B488
1143.12 Role of TRPC6 in high glucose-induced
podocyte apoptosis.
B-C. Liu, X. Song, L-L. Yang, D. Eaton
and H-P. Ma. Emory Univ. Sch. of Med.
B489
1143.13 Superoxide and hydrogen peroxide stimulate
renin release from juxtaglomerular cells.
M. Mendez. Henry
Ford Hosp..
B490
1143.14 The effect of allopurinol administration on
xanthine oxidoreductase and mitochondrial respiration in
broiler chickens.
T.L. Settle, E. Falkenstein, K. Blemings and
H. Klandorf. West Virginia Univ.
B491
1143.15 Hydrogen peroxide is not increased in
angiotensin II-stimulated neurons overexpressing superoxide
dismutase.
A.J. Case, R.F. Cruz and M.C. Zimmerman. Univ.
of Nebraska Med. Ctr. and Univ. of Nebraska-Lincoln.
B492
1143.16 Proteomic analysis of the cAMP/protein kinase
A (PKA) signaling pathway identifies PKA as a regulator
of cellular response to oxidative stress.
T. McCann, A.S.
Wilderman, Y. Guo, S.S. Taylor and P.A. Insel. UCSD and
HHMI.
1144. OXIDATIVE STRESS BIOLOGY
Poster
t
ue
. 7:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
,
e
xhiBit
h
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a-B
Presentation time: 12:45
pm
-3:00
pm
B493
1144.1 Differential effects of low pH on Ca
2+
-induced
ROS emission from mitochondrial complexes I and III.
D.P.
Lindsay, A.K.S. Camara, D.F. Stowe and M. Aldakkak. Med.
Col. of Wisconsin.
B494
1144.2 Attenuating complex I activity decreases p66
shc
phosphorylation and translocation to mitochondria during
cardiac ischemia reperfusion injury.
M. Yang, D.F. Stowe, J.S.
Heisner and A.K.S. Camara. Med. Col. of Wisconsin and VA
Med. Ctr.
B495
1144.3 HVCN1 contributes to superoxide production
independent of intracellular pH regulation.
P.M. O’Connor, J.
Sun and B.A. Mazer. Georgia Hlth. Sci. Univ.
B496
1144.4 Loud sound-induced hearing loss is prevented
by methylene blue.
T.M. Wilson, I. Omelcheko, S. Foster and
A.L. Nuttall. Oregon Hlth. & Sci. Univ.
B497
1144.5 Lysophosphatidic acid induces reactive oxygen
species generation through PLC/PKC/Nox pathway in PC-3
prostate cancer cells.
C-C. Lin, C-E. Lin, Y-C. Lin and H. Lee.
Natl. Taiwan Univ.
B498
1144.6 Oxidative stress and ER stress induce
Zidovudine (AZT)-mediated hepatic lipid accumulation.
A.
Banerjee, M.A. Abdelmegeed, S. Jang and B.J. Song.
NIAAA, NIH, Rockville.
B499
1144.7 Inspiratory muscle exercise reduces
lipoperoxidation in obese and healthy subjects: a pilot study.
C.C. Callegaro, L. Maldaner, L. Donato, A. Spring, F. Porto,
L. Chaves and R. Cattaneo. Univ. of Cruz Alta, Brazil.
B500
1144.8 Ketone supplementation reduces superoxide
production in cultured primary human dermal fibroblasts:
comparison of young versus aged cells.
S.L. Kesl, A.N. Moor,
M.Y. Jung, A.M. Poff, L. Gould and D.P. D’Agostino. Morsani
Col. of Med., Univ. of South Florida.
1145. ION TRANSPORT IN CELL DIFFERENTIATION,
MIGRATION, POLARIZATION AND ADHESION
(POSTERS)
Poster
t
ue
. 7:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
,
e
xhiBit
h
alls
a-B
Presentation time: 12:45
pm
-3:00
pm
B501
1145.1 Regulation of cell motility by Na
+
/H
+
exchanger
NHE1: implications for cancer development.
S.F. Pedersen.
Univ. of Copenhagen.
B502
1145.2 ERM proteins colocalize with the Na
+
/H
+
exchanger NHE1 in MCF-7 breast cancer cell invadopodia and
affect invadopodia number.
G.A.B. Roest and S.F. Pedersen.
Univ. of Copenhagen.
B503
1145.3 Stable expression of the sodium iodide
symporter in metastatic cancer cells: a novel imaging tool.
K.B.
Gagnon, D. Chapman, D.M.L. Cooper, S. Caine, V. Verge and
H. Nichol. Univ. of Saskatchewan.
B504
1145.4
b-Adrenergic receptor agonists known to
stimulate
b-arrestin-dependent signaling inhibit CFTR activity,
cell migration and airway epithelial restitution.
E.R. Peitzman
and S.M. O’Grady. Univ. of Minnesota, St. Paul.
B505
1145.5 Chloride channel inhibition reduces tail
regeneration in the developing vertebrate Ambystoma
mexicanum.
B.M. Franklin, R. Voss and J. Osborn. Univ. of
Kentucky.
B506
1145.6 Adenosine inhibits human T lymphocyte
migration via inhibition of KCa3.1 channels.
A.A. Chimote, V.
Kucher, N. Boiko, P. Hajdu, Z. Kuras, Y-H. Yun, O. Szilagyi
and L. Conforti. Univ. of Cincinnati and North Carolina A&T
State Univ.
B507
1145.7 Cortactin and the actin cytoskeleton control
the lateral membrane mobility of Kv1.3 channels.
G.V. Martin,
P. Hajdu, A.A. Chimote, K. Takimoto, O. Szilagyi and L.
Conforti. Univ. of Cincinnati, Nagaoka Univ. of Technol., Japan
and Univ. of Debrecen, Hungary.
B508
1145.8 The role of the Arp2/3 complex in the
cytoskeleton organization and actin-mediated sodium
reabsorption in kidney epithelial cells.
D.V. Ilatovskaya, V.
Chubinskiy-Nadezhdin, L.S. Shuyskiy, T.S. Pavlov, O.
Palygin, Y.A. Negulyaev and A. Staruschenko. Med. Col. of
Wisconsin and Inst. of Cytol., RAS, St. Petersburg.
PHYSIOLOGY TUESDAY
401
T
U
E
1146. STEM CELLS AND CELL GROWTH,
DEVELOPMENT AND DIFFERENTIATION
Poster
t
ue
. 7:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
,
e
xhiBit
h
alls
a-B
Presentation time: 12:45
pm
-3:00
pm
B509
1146.1 Lysophosphatidic acid inhibits megakaryocyte
differentiation in CD34
+
hematopoietic stem cells.
K-H. Lin,
C-L. Yao and H. Lee. Natl. Taiwan Univ. and Yuan Ze Univ.,
Taiwan.
B510
1146.2 The role of lysophosphatidic acid in
erythropoiesis in K562 human erythroleukemia cell line.
Y-H.
Ho, K-H. Lin and H. Lee. Natl. Taiwan Univ.
B511
1146.3 Osteoblast differentiation of adipose tissue-
derived mesenchymal stem cells (MSCs) is enhanced by bone
marrow MSC-conditioned medium.
M.M. Beloti, R.F. Abuna,
F.S. de Oliveira, R.B. Kato and A.L. Rosa. Sch. of Dent. of
Ribeirão Preto - Univ. of São Paulo.
B512
1146.4 Role of MMP-2 activation in oncostatin-M
induced cardiomyocyte dedifferentiation.
F. Fan, M.A.M, Ali,
B.G. Hughes and R. Schulz. Univ. of Alberta.
B513
1146.5 Characterization of cardiac progenitor cells
from adult murine skeletal muscle.
C.A. Pacak, I. Alpatov, S.
Fullen, S.F. Emmer and D.B. Cowan. Boston Children’s Hosp.
and Harvard Med. Sch.
B514
1146.6 Chronic binge alcohol-induced skeletal muscle
wasting: implications for satellite cell function.
L.E. Decker,
N.J. LeCapitaine, G.J. Bagby, S. Nelson and P.E. Molina.
Mandeville H.S., Mandeville, LA and LSU Hlth. Sci. Ctr., New
Orleans.
B515
1146.7 Polyamines enhance satellite cell activation
and expression of myogenic regulatory factors.
K.J. Thornton,
K.C. Chapalamadugu, M.E. Doumit and G.K. Murdoch. Univ.
of Idaho and Univ. of South Florida.
B516
1146.8 Chronic
a
1A
AR stimulation may increase adult
neurogenesis and parvalbumin interneurons.
A. Nielsen, K.
Collette, D. Perez and V. Doze. Univ. of North Dakota and
Cleveland Clin. Fndn.
B517
1146.9 Critical role of Sox9 in the differentiation of
mesenchymal stem cells to endothelial cells.
D.K. Agrawal, I.
Attairu, K.P. Djossou and D. Pankajakshan. Creighton Univ.
Sch. of Med.
B518
1146.10 Genotyped adipocytes to monitor adiponectin
expression in response to environmental stressors.
C. Zhang,
J.B. Alley, S.A. Samy, D. Bohman, F. Bovenzi, L. Fitzgerald,
J-M. Prot, M.L. Shuler and M. Ariza-Nieto. Cornell Univ. and
Guthrie Clin., Sayre, PA.
B519
1146.11 Osteogenic differentiation of human
mesenchymal stem cells induced by nanostructures.
S.Y.
Choi, P.D. Ryu, S-W. Joo and S.Y. Lee. Seoul Natl. Univ. and
Soongsil Univ., South Korea.
1147. CELL-BASED THERAPY FOR THE HEART
AND KIDNEY: FROM BENCH TO BEDSIDE
(POSTERS)
Poster
t
ue
. 7:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
,
e
xhiBit
h
alls
a-B
Presentation time: 12:45
pm
-3:00
pm
B520
1147.1 Beneficial effects of angiotensin (1-7) on
dysfunctional CD34
+
endothelial progenitor cells from patients
with heart failure.
S. Hazra, C.T. Cole-Jeffrey, C.J. Pepine,
M.J. Katovich, M.B. Grant and M.K. Raizada. Univ. of Florida.
B521
1147.2 Mesenchymal stem cells attenuate renal
inflammation, microvascular rarefaction and fibrosis in the
renovascular hypertension rat model.
M.A. Boim, E.B.
Oliveira-Sales, E. Maquigussa, P. Semedo, L.G. Pereira,
N.O. Camara, C.T. Bergamaschi and R.R. Campos. Fed.
Univ. of São Paulo.
B522
1147.3 Impact of augmenting intracellular ATP on the
inducible release of ATP from banked erythrocytes.
B.S. Kirby,
H. Zhu, D.A. Riccio and T.J. McMahon. Duke Univ. Med. Ctr.
and VA Med. Ctr.
B523
1147.4 Autonomic dysregulation and its prevention by
voluntary exercise in a mouse model of chronic widespread
pain (fibromyalgia).
R. Sabharwal, L.A. Rasmussen, K.A.
Sluka and M.W. Chapleau. Univ of Iowa and VA Med. Ctr.
B524
1147.5 Renal regeneration in diabetic nephropathy.
K.J. Kelly and J. Dominguez. Indiana Univ. Med. Sch.
B525
1147.6 Dystrophin insufficiency causes a Becker
muscular dystrophy-like phenotype in swine.
K. Hollinger,
C-X. Yang, J.W. Ross, G.A. Rohrer, D. Nonneman and J.T.
Selsby. Iowa State Univ. and USDA, Clay Center, NE.
B526
1147.7 Differences in the association between stress,
depression and cardiovascular disease risk factors in children
and adults.
S.C. Stanley, A.C. D’Audiffret, N. Pagano, S.J.
Frisbee and J.C. Frisbee. West Virginia Univ.
1148. REGULATION OF EPITHLIAL WATER AND
ION CHANNELS, TRANSCELLULAR AND
PARACELLULAR PERMEABILITY AND
EPITHELIAL POLARITY
Poster
t
ue
. 7:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
,
e
xhiBit
h
alls
a-B
Presentation time: 12:45
pm
-3:00
pm
B527
1148.1 Role of the epithelial Na
+
channels in
development of ARPKD.
T.S. Pavlov, V. Levchenko, D.V.
Ilatovskaya, O. Palygin and A. Staruschenko. Med. Col. of
Wisconsin.
B528
1148.2 ENaC gating is coupled to the distance
between the
a- and bENaC subunits at the base of the thumb
and wrist domains.
D.M. Collier and P.M. Snyder. Univ. of Iowa
Carver Col. of Med.
B529
1148.3 Mice lacking protein kinase C
a show enhanced
membrane localization and activity of the epithelial sodium
channel in the renal cortical collecting duct.
H-F. Bao, Q. Yue,
T.L. Thai, J.D. Klein, J.M. Sands and D.C. Eaton. Emory Univ.
TUESDAY PHYSIOLOGY
402
B530
1148.4 Deficiency of urokinase plasminogen activator
suppresses epithelial sodium channels in tracheal epithelial
cells.
H-L. Ji, Z. Chen, X. Liang, R. Zhao and M. Zhao. Univ. of
Texas Hlth. Sci. Ctr. at Tyler.
B531
1148.5 Rab22 is involved in regulation of the epithelial
sodium channel.
X. Liu, C. Bertuccio, D. Devor and M.
Butterworth. Univ. of Pittsburgh.
B532
1148.6 Acetylation modulates ENaC degradation. P.L.
Butler and P.M. Snyder. Univ. of Iowa.
B533
1148.7 Sex differences in the effects of
b-estradiol on
ENaC current in cell culture.
J.D. Mitzelfelt, M.M. Greenlee
and D.C. Eaton. Emory Univ.
B534
1148.8 Heterogeneous nuclear ribonucleoprotein A2/
B1 is a novel aldosterone target gene in the rat distal colon
epithelium.
D. Alvarez de la Rosa, I. Hernandez-Diaz, S.
Morales, G. Hernandez, E. Salido, C.M. Canessa and T.
Giraldez. Univ. of La Laguna, Univ. Hosp. NS Candelaria,
Santa Cruz de Tenerife, Univ. Hosp. of Canarias, La Laguna,
Spain and Yale Univ. Sch. of Med.
B535
1148.9 Evaluation of the H
2
S gasotransmitter system
as a regulator of transepithelial sodium absorption in native
lung epithelia (Xenopus laevis).
M. Althaus, A. Erb, A. Agné,
K.R. Olson, P. Glombik, W.G. Clauss and M. Fronius. Justus
Liebig Univ., Germany and Indiana Univ. Sch. of Med.-South
Bend.
B536
1148.10 Biomechanical forces differentially regulate
signaling in the cortical collecting duct.
R. Carrisoza, C.K.
Else, D. Flores, H.G. Lee, F.Y. Lee, R. Rohatgi and L.M.
Satlin. Mount Sinai Sch. of Med., Columbia Univ. Col. of P&S
and James J. Peters VA Med. Ctr.
B537
1148.11 Mechanosensitive activation of ATP-sensitive
K
+
channels in native pulmonary epithelium depends on
pannexin and connexin hemichannel mediated ATP release.
K.
Richter, K.P. Kiefer, M. Lintges, L. Geissert, W. Clauss and
M. Fronius. Justus Liebig Univ., Giessen.
B538
1148.12 Activation of electrogenic K secretion requires
BK channels in guinea pig distal colon.
D.R. Halm, J. Zhang
and S.T. Halm. Wright State Univ.
B539
1148.13 Ion transport across the murine retinal pigment
epithelium.
S.S. Arnason, S.B. Skarphedinsdottir and T.
Eysteinsson. Univ. of Iceland.
B540
1148.14 Inhibition of NF
kB activity in renal collecting
duct cells abolishes transepithelial voltage difference.
P.
Svenningsen and B.L. Jensen. Univ. of Southern Denmark.
B541
1148.15 Evidence for the existence of calcium signaling
domains in a renal cortical collecting duct cell line.
T.L. Thai,
H-F. Bao, B. Liu, H. Ma and D.C. Eaton. Emory Univ.
B542
1148.16 Deletion of claudin-7 in renal collecting duct
cells impairs paracellular chloride permeability.
J. Fan, R.
Tatum, J. Hoggard, B.G. Jeansonne and Y-H. Chen. Brody
Sch. of Med., East Carolina Univ.
B543
1148.17 GPCR activation of CFTR through two
independent phosphorylation pathways.
A. Billet and J.W.
Hanrahan. McGill Univ.
B544
1148.18 AQP2 poly-phosphorylation and water
permeability in inner medullary collecting duct.
C.A. Miranda,
J.W. Lee, C.L. Chou and M.A. Knepper. NHLBI, NIH.
B545
1148.19 Mechanisms of interferon gamma-induced
suppression of aquaporin 1 in murine intestinal epithelium.
M. Dicay, N. Ronaghan, M. Peplowski, C. Carati and W.K.
MacNaughton. Univ. of Calgary, Canada and Flinders Univ.,
Australia.
B546
1148.20 Prostaglandin receptor EP2- and EP4-
mediated aquaporin-2 membrane accumulation does not
depend on cAMP.
E.T.B. Olesen and R.A. Fenton. Aarhus
Univ., Denmark.
B547
1148.21 Intestinal epithelial endocytosis of commensal
bacteria is dependent on IFN
g-induced terminal web myosin
phosphorylation and brush border fanning.
L-L. Wu, W-T. Kuo,
W-H. Peng, K-S. Lu, Y-H. Ni and L.C-H. Yu. Natl. Taiwan Univ.
Col. of Med. and Natl. Taiwan Univ. Hosp.
B548
1148.22 Reduced transepithelial glucose movement
in metformin-treated airways correlates with inhibition of
hyperglycemia-induced bacterial growth.
J.P. Garnett, E.H.
Baker, J.S. Tregoning and D.L. Baines. St George’s, Univ. of
London and Imperial Col. London.
B549
1148.23 Zebrafish as a model to analyze macromolecule
absorption in intestinal enterocytes.
J.L. Cocchiaro, A. Navis,
M. Bagnat and J.F. Rawls. Univ. of North Carolina at Chapel
Hill and Duke Univ.
B550
1148.24 Paracellular urate transport in the placenta.
H. Sakurai, T. Kimura, A. Tsukada, S. Ohtsuki, I. Uehara,
S. Tanigaki, M. Iwashita and K. Ichida. Kyorin Univ. Sch. of
Med., Tokyo Metro. Ohtsuka Hosp., Kumamoto Univ. Fac Life
Sci, Kyorin Univ. Sch. of Med. and Tokyo Univ. Pharm. & Life
Sci., Japan.
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