791.7
The visualization and localization of glycogen
in Caki-2 renal carcinoma cells.
B. Lundbeck, C. Danielson
and G. Parker. Utah Valley Univ.
C178
791.8
Thiolmethyltransferase activity and selectivity
of heterologously expressed human enzymes.
E. Oduaran.
Roger Williams Univ.
792. GENETIC AND METABOLIC APPROACHES TO
OBESITY
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C179
792.1
Obesity: exploring a link between BMIi and
leptin.
S.P. Kennedy and N. Parmar. California State Univ.,
Channel Islands.
BIOCHEMISTRY MONDAY
245
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793. METABOLISM AND CANCER
Poster
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C180
793.1
Molecular mechanism of aniline induced
bladder cancer.
S. Kannan, R. Fielder, J. Tristan, E. Longoria
and A. Castillon. Southwest Texas Junior Col., Eagle Pass
and Uvalde.
C181
793.2
The anti-proliferative properties of Tradescantia
zebrina.
D.M. Moehring. Univ. of Wisconsin-Stout.
C182
793.3
Antitumoral potential ability of ATP and
antimicrobial peptides against leukemic stem cells.
E.J.
Paredes-Gamero, M.V. Buri, A. Ribeiro-Filho, C.M.V.
Barbosa, A. Nogueira-Pedro and A. Miranda. Fed. Univ. of
São Paulo.
C183
793.4
A new therapeuthical approach to block cancer
cachexia: focusing inhibition of STAT3.
K.A. Santos Silva,
Y. Dong, Y. Dong, D.J. Tweardy, W.E. Mitch and L. Zhang.
Baylor Col. of Med. and Fed. Univ. of São Paulo.
C184
793.5
Modulation of late apoptotic events by ammonia
in glutamine-deprived mouse hybridoma cells.
E.R. Gauthier
and A. Abusneina. Laurentian Univ., Canada.
C185
793.6
Protection of cigarette smoke-induced lung
injury in guinea pigs by inhalation of aerosolic all-trans retinoic
acid.
S. Mukherjee, M.W. Schaeffer, S. Sinha Roy and S.K.
Das. Meharry Med. Col.
C186
793.7
Mitochondria-targeted antioxidant mitoTEMPO
inhibits glycolysis and induces melanoma cell death by
blocking ROS-sensitive survival and metabolic pathways.
R.R.
Nazarewicz, A.E. Dikalova, A.T. Bikineyeva, S.V. Ivanov and
S.I. Dikalov. Vanderbilt Univ. Med. Ctr. and Yale Cancer Ctr.
C187
793.8
Antimycin induces apoptosis in rapamycin
resistant SW620 colorectal cancer cells.
B.L. Teran and J.
Thomas. Kean Univ., NJ.
C188
793.9
Activation of the hypoxia pathway and glycogen
metabolism.
E. Eppich, M. Whipple and G. Parker. Utah Valley
Univ.
C189
793.10 Circulating lymphocyte T cell levels following
radical non-small cell tumor surgery.
O.L. Tulp, G.P. Einstein, J.
Kowalski and M. Dancewicz. USAT Col. of Med., Montserrat.
794. METABOLISM AND NUTRITION
Poster
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C190
794.1
Generation and characterization of a
tamoxifen-inducible MGAT2 knockout mouse.
T. Banh, Y. Gao,
D.W. Nelson, M-I. Yen and C-L.E. Yen. Univ. of Wisconsin-
Madison.
C191
794.2
Influence of dietary intake on plasma
metabolites and lipids in C57BL/6J mice.
J. Meidenbauer, N.
Ta and T. Seyfried. Boston Col.
C192
794.3
Multiple cycles of acetyl-CoA enolization
catalyzed by citrate synthase and ATP-citrate lyase.
Q. Li, V.E.
Anderson, H. Brunengraber and G-F. Zhang. Case Western
Reserve Univ. and NIGMS, NIH.
C193
794.4
Evaluation of the bioavailability of vitamin D2 in
mushrooms in healthy adults.
J. Bogusz, G. Pagonis and M.F.
Holick. Boston Univ. Med. Ctr.
C194
794.5
Isolation and identification of vitamin D2 and
photobyproducts.
R. Keegan and M.F. Holick. Boston Univ.
Med. Ctr.
C195
794.6
Mushrooms not only produce vitamin D2 but
can also produce vitamin D3 and vitamin D4.
J. Williams, Z. Lu
and M.F. Holick. Boston Univ. Med. Ctr.
C196
794.7
Induction of Foxo3a by nutrient deprivation
regulates folliculogenesis.
S. Barilovits, K. Newsom and H.
Nick. Univ. of Florida.
C197
794.8
Effect of Tapinanthus bangwensis leaf extract,
clomiphene citrate and folic acid on reproductive hormones in
female Sprague Dawley rats.
S.C. Nwoke, A. Magbagbeola O,
A.O. Ebuehi, M. Omojufehinsi, S. Gbotolorun, U.A. Okafor,
A. Ani and G.O. Ajayi,. Univ. of Lagos, Nigeria and Albany
State Univ.
C198
794.9
Different dietary sources of omega-3
polyunsaturated fatty acids influences renal fatty acid
composition, gene expression, and risk of nephrocalcinosis in
female rats.
C.R. Oldaker, J. Gigliotti, V. Benedito and J. Tou.
West Virginia Univ. and Univ. of Virginia.
C199
794.10 Paracellular transport of soybean
b-conglycinin
using a Caco-2/HT29-MTX co-culture.
F.L. Wallace, G.J.
Mahler, A. Tan-Wilson and K.A. Wilson. Binghamton Univ.,
Binghamton and Vestal.
C200
794.11 Effects of soy protein isolate and/or omega-3
polyunsaturated fatty acid supplementation on bone health
in female rats with polycystic kidney disease.
M.S. Miller, C.
Oldaker, K. Maditz and J.C. Tou. West Virginia Univ.
C201
794.12 Electrochemical characterization of superoxide
radical chemistry and scavenging by natural products.
G. Lee,
S. Belli, F. Caruso and M. Rossi. Vassar Col.
C203
794.14 Zhx2 and the balance between cardiovascular
and hepatic health.
K.T. Creasy , E. Clinkenbeard and B.T.
Spear. Univ. of Kentucky.
C204
794.15 Catabolism of 4-hydroxy-2(E)-nonenal (HNE)
via omega oxidation in perfused rat livers.
J.M. Berthiaume, Q.
Li, S. Sadhukhan, F. Henry, G.P. Tochtrop, H. Brunengraber
and G. Zhang. Case Western Reserve Univ.
C205
794.16 Preliminary investigation of the nutritional
qualities, phytochemical properties and antioxidant activities of
aqueous extract of mistletoe leaves (Tapinanthus bangwensis)
grown on orange trees.
M. Omojufehinsi, S.C. Nwoke, N.A.
Imaga, A.O. Magbagdeola,, A.O. Ebuehi and U.A. Okafor.
Univ. of Lagos, Nigeria and Albany State Univ.
C206
794.17 Metabolic disorder in a mouse model on an
American diet: proteomic analysis of cardiovascular disease.
S.A. Whelan, M.E. Mccomb, J.L. Spencer, C.F. Heckendorf,
M.M. Bachschmid, D.A. Siwik, W. Colucci, R.A. Cohen and
C.E. Costello. Boston Univ. Sch. of Med.
C207
794.18 A conserved structural determinant located at
the interdomain region of mammalian IRE1
a. Z. Xue, Y. He, K.
Ye, Z. Gu, Y. Mao and L. Qi. Cornell Univ.
C208
794.19 The role of CSF1 in hepatocellular carcinoma-
recruited macrophages.
G. Dougherty, M.B. Duncan, C.E.
Rohlman, A. Rehman and P. Thakur. Albion Col., MI and
Georgia Hlth. Sci. Univ.
MONDAY BIOCHEMISTRY
246
795. METABOLISM AND NEURODEGENERATION
Poster
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C209
795.1
The serum homocysteine and lipid levels
at patients with ischemic stroke and vascular dementia.
N. Serdarevic. Clin. Ctr. Univ. of Sarajevo, Bosnia and
Herzegovina.
C210
795.2
Glia maturation factor activate mast cells
and induce chemokine CCL2 release: implication for
neurodegenerative diseases.
D. Kempuraj and A. Zaheer.
Univ. of Iowa and VA Hlth. Care Syst.
C211
795.3
Soluble oligomers of amyloid
b cause oxidative
stress and alter redox/methylation-linked gene transcription by
disrupting EAAT3-mediated cysteine uptake.
N. Hodgson, M.
Trivedi and R. Deth. Northeastern Univ.
C212
795.4
The brain-specific BNIP-2 homology protein
Caytaxin acts as a scaffold to transport ATP citrate lyase on
kinesin and induce neurite outgrowth.
J. Sun and B.C. Low.
Natl. Univ. of Singapore.
C213
795.5
The role of SEL1L in neurodegeneration.
W-H.
Chang , C. Krumm, A.B. Francisco and Q. Long. Cornell
Univ.
C214
795.6
Sphingolipid metabolism modulates motor
neuron degeneration in Drosophila.
I. Sahoo, S. Hebbar, K.A.
Osborne, D. Schwudke and R.S. Kraut. Sch. of Biol. Sci.,
Nanyang Technol. Univ., Singapore and Natl. Ctr. for Biol. Sci.,
Bangalore, India.
C215
795.7
Green ice in my freezer! Is our drinking
water safe? A qualitative and quantitative study of copper
contaminants in NYC public water supply.
A. Patruno and B.
Sampoli Benitez. Marymount Manhattan Col.
C216
795.8
Protein thiol-based probing of the cellular and
metabolic origins of brain oxidative stress.
E.S. Stredny, P.F.
Gillespie, C.C. Templeton and T.D. Foley. Univ. of Scranton.
796. AGING AND METABOLISM
Poster
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C217
796.1
Inhibition of Isw2-mediated chromatin
remodeling by calorie restriction extends lifespan by potentiating
stress response.
W. Dang and S. Berger. Baylor Col. of Med.
and Univ. of Pennsylvania.
C218
796.2
Defying protein isomerization in aging: baker’s
yeast limit a common protein damage with novel mechanisms.
A.N. Patananan and S.G. Clarke. UCLA.
797. CHEMICAL AND SYSTEMS BIOLOGY
Poster
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Presentation time: 12:25
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C219
797.1
Characterization of the intestinal tract
neuroendocrine cells in normal and regenerating Holothuria
glaberrima.
S. Qi Huang and J.E. García-Arrarás. Univ. of
Puerto Rico Rio Piedras Campus.
C220
797.2
The nature of sequence and structure
divergence in the haloalkanoate dehalogenase superfamily.
C. Pandya, S.D. Brown, D. Dunaway-Mariano, P.C. Babbitt,
Y. Xia and K.N. Allen. Boston Univ., UCSF and Univ. of New
Mexico.
C221
797.3
Phylogenetic analysis of nuclear, ribosomal,
mitochondrial, and chloroplastic DNA in Chlorella and related
green algae species.
B. Keller, T. Jensen, S. Larson, N. Patel,
K. Wichers, V. Freeman, R. Stubbendieck, A. Barnes and C.
Bailey. Univ. of Nebraska-Lincoln.
C222
797.4
Crosslinking mass spectrometry with novel aryl-
dialdehyde reagents reveal extended conformational dynamics
of RNA polymeraseII.
M.J. Trnka and A.L. Burlingame. UCSF.
798. FUNCTION AND EVOLUTION OF METABOLIC
NETWORKS
Poster
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Presentation time: 12:25
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C223
798.1
Human melanoma metabolic network analysis
with combined,
13
C NMR/bioreactor technique: testing the
Warburg effect.
A. Shestov, A. Mancuso, J.W. Locasale and
J.D. Glickson. Cornell Univ. and Univ. of Pennsylvania.
799. MANIPULATING METABOLIC NETWORKS
Poster
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C224
799.1
A neutron can make the difference: the
15
N
stable isotope effect on metabolic pathways.
M. Filiou, C.
Webhofer, M. Nussbaumer, R. Landgraf, G. Maccarrone and
C.W. Turck. Max Planck Inst. of Psychiatry, Munich.
800. BIOSYNTHESIS OF COMPLEX MOLECULES
Poster
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C225
800.1
TLC-based assay of ganglioside synthesis.
M.N. Czarnowski, A.C. Ettinger and K.H. Moore. Oakland
Univ., MI.
BIOCHEMISTRY MONDAY
247
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801. CHEMICAL BIOLOGY OF CELL DEATH
Poster
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C226
801.1
Signal amplification is critical for the induction
of unfolded protein response-mediated apoptosis.
D.K.
Banerjee, A. Banerjee, J.A. Martinez, M.O. Longas, K.
Baksi, A. Kotapadi, K.P.V.R.K. Prasad and J. Santiago. Univ.
of Puerto Rico Sch. of Med., Purdue Univ. Calumet and Univ.
Central del Caribe, PR.
C227
801.2
DNA binding and antiproliferative activity of
copper (II) complexes of quinolone-thiazole derivatives with
applications as a chemotherapeutic agent.
D.R. Foreman,
H.X. Lin, K.M. Fox, J.M. Tanski and L.A. Tyler. Union Col. and
Vassar Col.
C228
801.3
Synthesis, characterization and anticancer
activities of new Cu(II) complexes.
H.X. Lin, D.R. Foreman,
K.M. Fox, J.M. Tanski and L.A. Tyler. Union Col. and Vassar
Col.
802. EXPERIMENTAL AND COMPUTATIONAL
APPROACHES TO SYSTEMS
Poster
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C229
802.1
Computational model for monitoring of the
membrane potential with the fluorescent probe DiSC3(5).
V.V.
Lemeshko and J.A. Alvarez. Natl. Univ. of Colombia, Sede
Medellin.
803. MEMBRANE PROTEINS AS DRUG TARGETS
Poster
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C230
803.1
TTP4000, a soluble fusion protein inhibitor of
receptor for advanced glycation end products is an effective
therapy in animal models of Alzheimer’s disease.
B. Zhou, R.
Rothlein, J. Shen, C. Valcarce, J. Selmer, M. Hanhan, M.S.
Kindy, A.M.M. Mjalli and M.J. Kostura. TransTech Pharma
Inc., High Point, NC and Med. Univ. of South Carolina.
C231
803.2
Characterization of a glycoprotein of TTP4000 –
a soluble decoy rage antagonist.
J.L.R. Freeman, B. Zhou,
J.L. Meuth, N. Abu-Hashem, A.M.M. Mjalli and M.J. Kostura.
TransTech Pharma Inc., High Point, NC.
C232
803.3
Characterizing unique interaction domains
in sterol biosynthetic complexes for the control of fungal
pathogens.
K. Linscott, J. Chappell and T. Niehaus. Univ. of
Kentucky and Univ. of Florida.
C233
803.4
The fusion protein of Hendra virus contains a
leucine-isoleucine zipper in the transmembrane domain that
is important for association.
S. Webb, A. Popa and R. Dutch.
Univ. of Kentucky and Yale Univ. Sch. of Med.
C234
803.5
Single clone expression cloning and protein
microarray platforms for novel extracellular receptor-ligand
identification.
I. Tom, G. Quinones, A. Estevez, M. Paluch, K.
Bowman, Y. Franke, K. Billeci, P. Hass, J. Tang, N. Lewin-
Koh, D. Eaton, J-P. Stephan and L. Gonzalez. Genentech.
C235
803.6
The motion control of the iron-sulfur-protein in
complex III.
L. Esser, F. Zhou, C-A. Yu and D. Xia. NCI, NIH
and Univ. of Oklahoma Stillwater.
C236
803.7
Disabeled-2 modulates platelet-cancer
cell interactions through its sulfatide binding domain.
K.J.
Andreano, X. Fu, D. Capelluto and C. Finkielstein. VPI and
State Univ.
C237
803.8
Membrane repair protein Mitsugumin 53 as
a potential therapeutic for the treatment of traumatic brain
injury.
J.G. Moloughney, J. Alloush, O. Le-Hoang and N.L.
Weisleder. UMDNJ, Piscataway and The Ohio State Univ.
C238
803.9
Synthesis and structure-activity relationship
of new cationic lipid derivatives.
B. Caroyez, C. Lonez, J-M.
Ruysschaert, I. Jabin and M. Vandenbranden. Univ. Libre of
Brussels.
C239
803.10 The molecular mechanism of inhibition of newly
identified inhibitors of human MDR1 P-glycoprotein.
P.D. Vogel,
F.K. Brewer, C.A. Follit, I.R. Rossi and J.G. Wise. Southern
Methodist Univ.
C240
803.11 In silico and in vitro drug screening for novel
inhibitors of human MDR1 P-glycoprotein.
F.K. Brewer, C.A.
Follit, I.R. Rossi, V.J. Rossi, P.D. Vogel and J.G. Wise.
Southern Methodist Univ.
C241
803.12 Development of antagonists for the protease
activated receptor-2.
J. Hoffman, A. Flynn, D.V. Tillu, C.L.
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