POSTOPERATIVE ANALGESIA WITH NEFOPAM AND NON-STEROIDAL ANTI-INFLAMMATORY
DRUGS IN PATIENTS AFTER SURGERY FOR TUMORS OF HEAD AND NECK
Balandin V.V., Gorobets E.S.
Blokhin Russian Research Center of Oncology, Moscow, Russia
correspondence to:
Gorobets E.S.
e-mail:
egorobets@mail.ru
Abstract:
Materials and Methods: 83 adult patients included in the study were divided into two
groups.Patients of the group-1(n– 49) had medium level of pain after cancer head and neck surgery. Patients
of the group-2 (n– 34) had severe pain. Three first postoperative days their post-operative multimodal
analgesia started with tenoxycam 20 mg i.m. after induction of anesthesia, then every 24 hour (58 patients).
25 patients got ketoprofen 100 mg i.m. every 8-12 hours instead of tenoxycam. All patients had nefopam 30
mg i.m. 30 min prior the end of surgery procedure, and every 8 hours afterwards. 7 patients of the group-1
had more than 4 pain scores (day 1), 4 patients - at the day 2. They received tramadol or
paracetamoladditionally. 7 patients (group-2) also had up to 5 pain scores on the day 1, 5 patients had 4 pain
scores on the day 2, and 3 patients 4 pain scores on the day 3. All that patients received additional analgesia
with tramadol or trimeperidine once a day. 8.4% of patients suffered from adverse reactions (tachycardia,
PONV, and sweating). Conclusion: this method of multimodal postoperative analgesia is very simple and
fairly efficient.
Key words:
nefopam, tenoxycam, ketoprofen, multimodal postoperative analgesia, head and neck cancer
surgery
AN-1401-043
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