AN-1303-025
EXPRESS DIAGNOSTICS OF ENDOTOXAEMIA DURING POSTOPERATIVE PERIOD IN CARDIAC
SURGICAL PATIENTS
Yaroustovsky M.B., Samsonova N.N., Rogalskaya E.A., Klimovich L.G., Plyush M.G., Abramyan M.V.,
Krotenko N.P., Niyazmatov A.A.
Bakulev Scientifi c Center for Cardiovascular Surgery of the Russian Academy of Medical Sciences,
121552, Moscow, Russia
Medical technologies development and recent approaches in management of patients with septic
complications during the early postoperative period present new obstacles to the laboratory service.
Endotoxin is a main agent in the systemic inflammatory cascade and plays important role in sepsis
pathogenesis. Recent express methods of diagnostics allow determining blood activity of endotoxin during
30-50 min. 55 ICU patients with clinical and laboratory signs of systemic inflammatory response syndrome
(SIRS) after cardiac surgery were studied in the single-center prospective research. Endotoxaemia was
diagnosed by express tests. Level of endotoxaemia was assessed before and after sorption in 15 patients
receiving complex intensive care with selective lipopolysaccharide (LPS) adsorption. Endotoxaemia level
assessment allows to define indications for different programs of intensive care in time and to assess its effi
ciency. Test systems for assessment endotoxin level based on the principle of interaction antigen - antibody
(EAA and МАЧ
-endotox spp.) is a most effi cient for express diagnostics of endotoxaemia.
Key words: sepsis, endotoxin, express diagnostics of endotoxaemia
AN-1303-030
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