Anesthesiologists are involved: Anesthesiologists are involved



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tarix02.01.2022
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leukotrienes, endothelin,

  • complement

  • interleukins

  • tumor necrosisfactor

  • and others



  • This why a patient may die of multiple organ failure after traumatic hemorrhage, even when bleeding has been controlled and the patient resuscitated to normal vital signs and perfusion.

    • This why a patient may die of multiple organ failure after traumatic hemorrhage, even when bleeding has been controlled and the patient resuscitated to normal vital signs and perfusion.





    • The CNS is the prime trigger of the neuroendocrine response to shock, which maintains perfusion to the heart, kidney, and brain at the expense of other tissues.

    • Regional glucose uptake in the brain changes during shock.

    • Reflex activity and cortical electrical activity are both depressed during hypotension; these changes are reversible with mild hypoperfusion but become permanent with prolonged ischemia.




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