The Gut is one of the earliest organs affected by hypoperfusion and may be the prime trigger of MOSF.
Intestinal cell death causes a breakdown the barrier function of the gut that results in increased translocation of bacteria to the liver and lung, thereby potentiate ARDS.
The liver has a complex microcirculation and has been demonstrated to suffer reperfusion injury during recovery from shock.
Failure of the synthetic functions of the liver after shock are almost always lethal
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Skeletal muscles:
tolerates ischemia better than other organs
The large mass of skeletal muscle, though, makes it important in the generation of lactate and free radicals from ischemic cells.
