Anesthesiologists are involved: Anesthesiologists are involved

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• The Gut is one of the earliest organs affected by hypoperfusion and may be the prime trigger of MOSF.

• Intestinal cell death causes a breakdown the barrier function of the gut that results in increased translocation of bacteria to the liver and lung, thereby potentiate ARDS.

• The liver has a complex microcirculation and has been demonstrated to suffer reperfusion injury during recovery from shock.

• Failure of the synthetic functions of the liver after shock are almost always lethal

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• Skeletal muscles:

• tolerates ischemia better than other organs

• The large mass of skeletal muscle, though, makes it important in the generation of lactate and free radicals from ischemic cells.

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