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these inherited cancers. And then there are those called “sporadic” that represent 95% of all
clinical cancers and are caused by a variety of widely differing carcinogens present in the
environment (chemical, physical and biological agents). In order to explain the development
of sporadic cancers two main theories have been proposed and a third is increasingly gaining
adepts (see below). Given their clinical importance and the magnitude of their incidence, our
analysis will mainly concentrate on explanations on how known causative agents generate the
sporadic variety of cancers.
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