Aura 2016 Supplementary data

Table S4.8 Mycobacterium tuberculosis resistance to first-line antimycobacterial agents, 2005–14

Isolates and resistance patterns	2005	2006	2007	2008	2009	2010	2011	2012	2013	2014
Total TB cases notified to NNDSS^a	1075	1208	1130	1220	1307	1364	1389	1316	1263	1339
Total number of laboratory isolates^b	706	775	782	913	966	1023	1059	984	936	1027
Fully susceptible	638	660	685	801	823	903	941	852	814	898
Resistant to isoniazid only^c	42	74	59	57	94	67	65	73	67	65
Resistant to rifampicin only^c	2	1	3	2	6	3	1	3	3	7
Resistant to isoniazid and rifampicin (susceptible to ethambutol and pyrazinamide)	6	11	11	12	15	13	18	14	10	7
Resistant to isoniazid, rifampicin and ethambutol (susceptible to pyrazinamide)	4	2	1	6	1	1	2	2	4	1
Resistant to isoniazid, rifampicin and pyrazinamide (susceptible to ethambutol)	1	0	7	3	8	16	2	1	2	3
Resistant to isoniazid, rifampicin, ethambutol and pyrazinamide	1	3	0	1	0	1	5	3	7	6
Total MDR strains (resistant to at least isoniazid and rifampicin; sum of above 4 rows)	12	16	19	22	24	31	27	20	23	17
Percentage of all laboratory isolates that are MDR-TB	1.7	2.1	2.4	2.4	2.5	3.0	2.5	2.0	2.5	1.7
XDR-TB (resistant to at least isoniazid and rifampicin, plus fluoroquinolone and an injectable agent)	0	0	0	0	0	2	0	0	0	1

MDR-TB = multidrug-resistant tuberculosis; NNDSS = National Notifiable Diseases Surveillance System; TB = tuberculosis; XDR-TB = extremely drug-resistant tuberculosis

a Clinically diagnosed cases of tuberculosis are reported to NNDSS.

b Some laboratory isolates may have been tested against agents other than first-line agents.

c Notified cases may have reported resistance to antimicrobials other than first-line agents.

Note: Drug susceptibility test data was not provided by Western Australia for 2005, 2006 and 2007; or the Australian Capital Territory for 2005.

Source: NNDSS snapshot (23 June 2015) 373 and 374