Poster presentation
265
A SIMPLE AND CONVENIENT METHOD FOR
ARYLSULFONYLATION OF 2,5-DIMETHYLBENZIMIDAZOLE
K. Abdireymov, B. J. Elmuradov
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of
sciences of the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent
Benzimidazoles and their derivatives have a wide spectrum of biological activity. For
example, among heterocyclic compounds containing a benzimidazole skeleton, there are
a number of effective drugs that are recommended for use in agriculture (
albendazole,
carbendazim, benomyl
) and medicine (
dibazole
). Therefore,
conducting targeted
research on the synthesis and study of the biological activity of substituted
benzimidazoles is of both theoretical and practical interest [1-3].
In
this work, we curried out interaction of 2,5-dimethylbenzimidazole (
1
) with
substituted arylsulfonyl chlorides. The aim of this work to study “
structure-biological
activity
” relationship of the synthesized arylsulfonyl derivatives of benzimidazoles:
Arylsulfonylation of 2,5-dimethylbenzimidazole (
1
) with substituted arylsulfonyl
chlorides curried out in the presence of triethylamine at room temperature for 4 hours.
As results we have
synthesized corresponding N
1
-arylsulfonyl-2,5-dimethyl-
benzimidazoles (
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