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Distribution ↑adipose/↓lean, water Binding/Localization



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tarix02.01.2022
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Distribution

  • ↑adipose/↓lean, water
  • Binding/Localization

    • ↓albumin
  • Biotransformation

  • Elimination

    • ↓GFR












    Less stringent control reasonable in those with a long history of diabetes, limited life expectancy, or comorbid conditions

    • Less stringent control reasonable in those with a long history of diabetes, limited life expectancy, or comorbid conditions



    Hematologic

    • Hematologic

    • Endocrine agents

    • Cardiovascular agents

    • Central Nervous System Agents

    • Anti-infective









    Influenced by the way risk information is presented to the patient

    • Influenced by the way risk information is presented to the patient

    • Multimorbidity patients face more preference-based and complex decisions

    • Eliciting preferences may make clinical management more time-consuming




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