Class: Benzodiazepine (related to lorazepam (Ativan)); controlled substance Mechanism of Action

Midazolam (Versed)
Class: Benzodiazepine (related to lorazepam (Ativan)); controlled substance
Mechanism of Action: suppresses the central nervous system by reversibly interacting with gamma-amino butyric acid (GABA) receptors in the central nervous system which then exhibits sedative, anxiolytic, amnesic and hypnotic activities
Routes of Administration: IV, IM, IO, intranasal
Uses: sedation and active seizures
Doses:

DEMCA Protocol	Indications	Dose	Maximum Dose
Pediatric Bradycardia	Sedation for transcutaneous pacing	0.05 mg/kg IV/IO titrated slowly; may repeat once in 5 minutes	0.1 mg/kg
Pediatric Seizures	Active seizures	0.05 mg/kg IV/IO , 0.1 mg/kg IM; up to a maximum of individual dose 5 mg)	May repeat ONCE up to maximum individual dose
Obstetrical Emergencies	Pregnant women with continued active seizures after magnesium administration	2 – 5 mg (0.05 mg/kg) IV/IO/IM	5 mg per dose

Side Effects: respiratory depression
How Supplied: 5 mg/1 mL vials
Special Documentation: narcotic sheet must be filled out when midazolam is used and witness must sign off when waste occurs