Debridement

2

3

High Osmolarity

Wound bed

Dermis

Subcutis

Low pH Level

W

ound Healing

W

ound Br

eakdown

0

1

2

3

4

5

6

7

8

9

10

11

12

13

14

Active Leptospermum 

Honey pH: 3.5– 4.5

Neutral

---

clinical iSSue

Topical products containing papain, used for removal of 

necrotic tissue, control of inflammation, reduction of wound 

odor, and rehydration of the skin, are no longer approved 

for use in the United States.

17 

 With the loss of papain-urea 

based debridement agents, there was a need to find a safe 

and cost-effective alternative for debridement of non-viable 

tissue and for wound bed preparation.

24

incluSiOn criteria

Five patients were asked to participate in an open label 

pilot study. Selection criteria were limited to lower extremity 

ulcers with a minimum of 50% devitalized tissue.  Active 

Leptospermum Honey (ALH) has experienced increased 

attention in the literature as an effective agent to promote 

autolytic debridement.

9, 25

  Many patients in the outpatient 

setting are not candidates for surgical debridement. 

OutcOMe

To determine the efficacy of this product for debridement 

of devitalized tissue as an adjunct to a successful wound 

treatment program.