Description

anticoagulation. 
Delayed Onset of HIT and HITT 
Heparin-induced Thrombocytopenia and Heparin-induced Thrombocytopenia and Thrombosis can 
occur up to several weeks after the discontinuation of heparin therapy. Patients presenting with 
thrombocytopenia or thrombosis after discontinuation of heparin should be evaluated for HIT and 
HITT. 
Use In Neonates 
This product contains the preservative benzyl alcohol and is not recommended for use in neonates. 
There have been reports of fatal ‘gasping syndrome’ in neonates (children less than one month of age) 
following the administration of intravenous solutions containing the preservative benzyl alcohol. 
Symptoms include a striking onset of gasping respiration, hypotension, bradycardia, and 
cardiovascular collapse. 
Preservative-Free Heparin Lock Flush Solution, USP should be used for maintaining the patency of 
intravenous injection devices in neonates. 

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NDA 17-037/S-158 
Page 17 
PRECAUTIONS 
General 
In infants, the cumulative amounts of heparin and benzyl alcohol received from the frequent 
administration of Heparin Lock Flush Solution during a 24-hour period must be considered. Where 
preservative-free heparin lock flush solution is indicated, HEP-LOCK
U/P is available. 
Precautions must be exercised when drugs that are incompatible with heparin are administered through 
an indwelling intravenous catheter containing Heparin Lock Flush Solution. (See DOSAGE AND 
ADMINISTRATION, Maintenance Of Patency Of Intravenous Devices.) 
Thrombocytopenia, Heparin-induced Thrombocytopenia (HIT) and Heparin-induced 
Thrombocytopenia and Thrombosis (HITT) 
See WARNINGS. 
Increased Risk To Older Patients, Especially Women 
A higher incidence of bleeding has been reported in patients, particularly women, over 60 years of age.