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Therapeutic Anticoagulant Effect With Full-Dose Heparin



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Therapeutic Anticoagulant Effect With Full-Dose Heparin 
Although dosage must be adjusted for the individual patient according to the results of suitable 
laboratory tests, the following dosage schedules may be used as guidelines: 
METHOD OF 
ADMINISTRATION 
FREQUENCY 
RECOMMENDED DOSE
[based on 150 lb (68 kg) patient] 
Deep Subcutaneous
(Intrafat) Injection 
Initial dose 
5000 units by IV injection, followed 
by 10,000 to 20,000 units of a 
concentrated solution, subcutaneously 
A different site should be used for 
each injection to prevent the 
development of massive 
hematoma 
Every 8 hours 
or 
8000 to 10,000 units of a 
concentrated solution 
Every 12 hours 
15,000 to 20,000 units of a 
concentrated solution 
Intermittent Intravenous Injection 
Initial dose 
10,000 units, either undiluted or in 50 
to 100 mL of 0.9
% Sodium Chloride 
Injection, USP 
Every 4 to 6 hours 
5000 to 10,000 units, either undiluted 
or in 50 to 100 mL of 0.9
% Sodium 
Chloride Injection, USP 
Intravenous Infusion 
Initial dose 
5000 units by IV injection 
Continuous 
20,000 to 40,000 units/24 hours in 
1000 mL of 0.9
% Sodium Chloride 
Injection, USP (or in any compatible 
solution) for infusion 
 
Pediatric Use 
Follow recommendations of appropriate pediatric reference texts. In general, the following dosage 
schedule may be used as a guideline: 
Initial Dose 
50 units/kg (IV, drip) 
Maintenance Dose 
100 units/kg (IV, drip) every 4 hours, or 20,000 units/m
2
/24 hours continuously 
Geriatric Use 
Patients over 60 years of age may require lower doses of heparin. 
Surgery of the Heart and Blood Vessels 
Patients undergoing total body perfusion for open-heart surgery should receive an initial dose of not 
less than 150 units of heparin sodium per kilogram of body weight. Frequently, a dose of 300 units per 
kilogram is used for procedures estimated to last less than 60 minutes, or 400 units per kilogram for 
those estimated to last longer than 60 minutes. 


NDA 17-037/S-158 
Page 11 

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