– Occurs in setting of cancer (especially mucinous adenocarcinoma) or other systemic wasting illness
– May embolize
– Grossly, small or large fibrin masses, without organisms, present at lines of closure on the aortic or mitral valves
– Microscopically, fibrin and entrapped red blood cells, no inflammation
♦ Libman-Sacks disease (verrucous endocarditis):
– Seen in systemic lupus erythematosus (SLE)
– Multiple small leaflet vegetations, usually on non_x0002_flow side (ventricular surface) of mitral and/or tricuspid valves
– Microscopically, fibrin intermixed with cellular debris and scattered inflammatory cells
Micropreparation
Rheumatic acute warty endocarditis.
Hematoxylin and eosin staining:
a - thrombotic overlays (warts) on the surface of the mitral valve,
devoid of endothelial cover;
b - lymphohistiocytic infiltrates in the valve leaflet;
c - full-blooded vessels
Focus of necrosis, valve leaflets
without sting and imposition
fresh blood clots, without
signs of an organization with
limited number of colonies Microorganisms.
• At the base of the clots of the valves
Clapon Gusto; infiltrated neutrophilic leukocytes.
• myocardial vessels, microbial emboli
• Around the embolus infiltrated
leukocytes.