Electron Ionization (EI) Induced Mass Spectral Analysis of Substituted Phenylacetamides


Scheme 3: Mass spectral fragmentation pattern of phenyl substituted N-Phenylacetylmorpholine amides. CONCLUSION



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electron-ionization-ei-induced-mass-spectral-analysis-of-substitutedphenylacetamides

Scheme 3: Mass spectral fragmentation pattern of phenyl substituted N-Phenylacetylmorpholine amides.
CONCLUSION
In summary, the mass spectral fragmentation patterns of these amies were found to be unique and depends on the 
substitution on both the phenyl ring and amines. These fragmentation patterns are useful for unambiguous identification 
of these amides after their GC MS analysis.
ACKNOWLEDGEMENTS
The authors thank Head, Syntheic Chemistry Division and Director, Defence Reserach and Development Establishment 
(DRDE), Gwalior for his keen support and encouragement.
REFERENCES
[1]
Galewicz-Walesa K, Pachuta-Stec A (2003) The synthesis and properties of n-substituted amides of 1- (5-methylthio-1, 2, 
4-triazol-3-yl) -cyclohexane-2-carboxylic acid. Medical Academy in Lublin 9: 118-125.
[2]
Siddiqui N, Alam MS, Ahsan W (2008) Synthesis, anticonvulsant and toxicity evaluation of 2-(1H-indol-3-yl)acetyl-N-
(substituted phenyl)hydrazine carbothioamides and their related heterocyclic derivatives. Acta Pharm 58: 445-454.
[3]
Moise M, Sunel V, Profire L, Popa M, Lionte C (2008) Synthesis and antimicrobial activity of some new (sulfon-aminophenyl)-
amide derivatives of N-(4-nitrobenzoyl)-phenylglycine and N-(4-nitrobenzoyl)-phenylalanine. Farmacia 41: 283-290.
N
O
O
H
HN
O
-87
C
H
132
C
O
-CHO
-29
103
C
N
O
O
114
C
N
O
O
H
N
O
86
-CO
-28
105
Base Peak
CH
2
Me
Me
Me
219
H
N
70
-16
-28
42


Gupta et al
Der Chemica Sinica, 2017, 8(1):218-222

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