Generic Name (U-100, except where noted) Brand Name Manufacturer Form Delivery Cloudy or Clear Onset Peak Duration



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Generic Name 

(U-100, except where 

noted)

Brand Name

Manufacturer

Form

Delivery

Cloudy or Clear

Onset

Peak

Duration

Rapid Acting

insulin aspart

NovoLog


Novo Nordisk

analog


syringe; prefilled, 

300-unit disposable 

pen; reusable pen 

with 300-unit 

cartridges; pump

clear


10 to 20 min.

30 to 90 min.

3 to 5 hours

insulin human

Afrezza

Sanofi 


human

inhaler with 4- and 

8-unit cartridges

N/A (inhaled powder) 10 to 20 min.

12 to 15 min.

3 hours


insulin glulisine

Apidra


Sanofi

analog


syringe; prefilled, 

300-unit disposable 

pen; pump

clear


10 to 20 min.

30 to 90 min.

3 to 5 hours

insulin lispro

Humalog

*

Eli Lilly

analog

syringe, prefilled 



disposable pen, 

reusable pen with 

cartridges, pump

clear


10 to 20 min.

30 to 90 min.

3 to 5 hours

Regular


Regular

Humulin R



+

Eli Lilly

human

syringe


clear

30 to 60 min.

2 to 4 hours

5 to 8 hours

Regular

Novolin R



Novo Nordisk

human


syringe

clear


30 to 60 min.

2 to 4 hours

5 to 8 hours

Intermediate Acting

NPH

Humulin N



Eli Lilly

human


syringe; prefilled, 

300-unit disposable 

pen

cloudy


1 to 3 hours

8 hours


12 to 16 hours

NPH


Novolin N, ReliOn 

(Walmart)

Novo Nordisk

human


syringe

cloudy


1 to 3 hours

8 hours


12 to 16 hours

Long Acting

insulin detemir

Levemir


Novo Nordisk

analog


syringe; prefilled, 

300-unit disposable 

pen

clear


1 hour

No peak


20 to 26 hours

insulin glargine

Lantus

Sanofi


analog

syringe; prefilled, 

300-unit disposable 

pen


clear

1 hour


No peak

20 to 26 hours

Ultra Long Acting

insulin glargine U-300 Toujeo

Sanofi

analog


prefilled, 300-unit 

disposable pen

clear

6 hours


No peak

36 hours


Mixtures

50% lispro prota-

mine/50% insulin 

lispro


Humalog Mix 50/50

Eli Lilly

analog

syringe; prefilled, 



300-unit disposable 

pen


cloudy

10 to 15 min.

Varies

10 to 16 hours



75% lispro protamine 

(NPL)/25% insulin 

lispro

Humalog Mix 75/25



Eli Lilly

analog


syringe; prefilled, 

300-unit disposable 

pen

cloudy


10 to 15 min.

Varies


10 to 16 hours

70% aspart prota-

mine/30% insulin 

aspart


NovoLog Mix 70/30

± Novo Nordisk

analog


syringe; prefilled, 

300-unit disposable 

pen

cloudy


5 to 15 min.

Varies


10 to 16 hours

70% NPH/30% 

Regular

Humulin 70/30



Eli Lilly

human


syringe; prefilled, 

300-unit disposable 

pen

cloudy


30 to 60 min.

Varies


10 to 16 hours

70% NPH/30% 

Regular

Novolin 70/30



±

ReliOn (Walmart)

Novo Nordisk

human


syringe

cloudy


30 to 60 min.

Varies


10 to 16 hours

Less Commonly Used Insulins

regular U-500

Humulin R U-500



 

+^

Eli Lilly

human

syringe


clear

30 min.


8 hours

Up to 24 hours

insulin lispro U-200

Humalog U-200



*^

Eli Lilly

analog

prefilled, 600-unit 



disposable pen

clear


15

30 to 90 min.

3 to 5 hours

Key


* 

Note difference between Humalog and Humalog U-200. 



Note difference between Humulin R and Humulin R U-500. 



± 

Note difference between Novolin 70/30 (70% NPH/30% Regular) and NovoLog Mix 

70/30 (70% aspart protamine/30% aspart). 

^

 

U-100, U-200, U-300, and U-500 are different concentrations of insulin. Higher concentrations are typically used in very insulin-resistant people.



Insulins Available in the United States

M ARCH/APRIL 201 5



 

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