Kuru Fatal Familial Insomnia (ffi)

• Kuru

• Fatal Familial Insomnia (FFI)

• Creutzfeldt-Jakob disease (CJD)

Phospholipase A2 Inhibitors prevent prion replication.

• Phospholipase A2 Inhibitors prevent prion replication.

• Platelet-activating Factor Antagonists also inhibits prion replication.

• Bate et al.,2004

• Drugs which share a N-benzylidene-benzohydrazide core structure.

• Trimethylamine N-oxide (TMAO), can prevent formation of PrPSc.