My ambition is to become a successful business manager. When you are talking about something very important that you want to achieve, use aim or ambition : ‘Her ambition is to represent her country in the Olympic Games.’ ‘Our ultimate aim is to find a cure for the disease.’ 3
I have always had a strong desire of becoming somebody.
I have always had a strong desire to become somebody. a desire to do sth (NOT of doing ): ‘She has no desire to travel and prefers to stay at home.’ despite 1
Despite the train was empty, he came and sat in front of me.
Although the train was empty, he came and sat in front of me. Despite the train being empty, he came and sat in front of me. Despite and in spite of are prepositions (NOT conjunctions). Unlike although (a conjunction), they cannot introduce a clause that has a finite verb (‘was’). Compare: ‘In spite of/Despite owning two cars, he can’t drive.’ ‘Although he owns two cars, he can’t drive.’ 2
Despite of my qualifications, I couldn’t get a job.
Despite my qualifications, I couldn’t get a job. In spite of my qualifications, I couldn’t get a job. despite sth (WITHOUT of): ‘Despite the heat, she wouldn’t take her coat off.’ in spite of sth (WITH of): ‘In spite of the heat, she wouldn’t take her coat off.’ destroy 1
This unpleasant man with his endless complaints destroyed my journey.
This unpleasant man with his endless complaints spoilt my journey. When you mean ‘remove the pleasure or enjoyment from’, use