Microsoft Word Materiallar Full

SPECTROSCOPIC INVESTIGATED INTERACTION BETWEEN SILVER 

NANOCOMPOSITES BASED OF GUMMIARABIC AND DOXORUBICIN FOR DRUG 

DELIVERING 

Samira MAMMEDOVA, Shamo TAPDIQOV, Nizami ZEYNALOV  

Institute of Catalysis and Inorganic Chemistry named after aсad. M.F.Nagiyev ANAS 

 

 

[e-mail] 

 

Polymeric nanoparticles may represent the most effective nanocarriers for prolonged drug delivery. The early in vitro 

and in vivo development of polymeric nanoparticles loaded with drugs using polyalkylcyanoacrylate-based nanoparticles 

releasing doxorubicin led to multiple reports using polymer-based materials for drug delivery. It is known that Ag and Au 

nanoparticles as drug delivery systems enable unique approaches for cancer and other deadly diseases treatment [1].  

Polymer–drug conjugates are one of the most investigated types of. Polymer–drug conjugates are formed through side-

chain grafting of drugs to polymer chains, allowing them to deliver high doses of chemotherapeutic drugs. Polymeric 

nanoparticles may represent the most effective nanocarriers for prolonged drug delivery [2]. 

Research in used gummiarabic (GA) which separated from gum Arabica (Acacia Senegal, Mη=107). The Ag 

nanoparticles  synthesis (vacuum condition) in 2% deionization water solution of GA add 5 sm3 0.04 mol/L AgNO3 and 

influence with ultra-violety rays (3÷60 min.). Then, nanocomposite precipitate with ethanol or acetone. The size and phases 

of Ag nanoparticles determination with Advance D8 (Bruker). It was determined that the size of nanoparticles changed 

32÷48 nm. The study of complex possibility between gummiarabic and doxorubicine investigation with UV-Vis 1800 

(Shimadzu) and IR-Furye spectrophotometers method.  

The synthesis of nanocomposite-doxorubicin complex take followen method: To add 1 sm3 doxorubicin (C=0,17 

mmol/L) solution into 2 sm3 polysacharides-Ag composites (C=5×10-3 mg/sm3) solution and mixture 60 min. Then 

exploration UV-Vis spectr in pH=1÷10 medium. Doxorubicin is commonly used to treat some leukemias and Hodgkin's 

lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma, multiple myeloma, 

and others. Show that formation nanoparticles-doxorubicin complex mainly occurs the 190→208 nm wavelengths on 

polysacharade`s >C=O functional groups. Also the four main absorbing strips of doxorubicin – 234, 253, 288 and 495 nm 

undergo chemists shift (∆λ=12-15 nm). It was shown that increases to pH=7-8 the size of Ag-doxorubicin particles 

decreases and pH=9-10 the size of particles begin to increases again. The 410 nm absorption strips of Ag undergo 409÷418 

nm interval and the 3400, 1620, 1460, 1380, 1060 sm-1 absorption lines of GA slightly altered. Also, the influence of the 

polymer, antibiotics concentration and the size of Ag nanoparticles to formation of complex. It was determined that the 

complex of Ag-polysacharide-doxorubicin generation between >C=O, -CH2OH, -COOH, -COH, >C+ OH of 

polysacharides and –NH2, –OH, –NH3+ groups of doxorubicin with hydrogen bonds, electrostatic and van der-Waals 

interaction with UV-Vis and IR-Furye spectrophotometric method.  

The nanocomposite keep their physical properties and structure and for this reason  GA-Ag solids and colloidal solution 

to use effective carries for the transport of doxorubicin.