Oncologic Emergencies Dr Karenza Alexis

Breakdown of nucleic acid, catabolism of hypoxanthine and xanthine leads to elevated uric acid

Potassium and phosphate are present at high levels in cytoplasm

LDH also released but not considered part of syndrome

Tumor Lysis Syndrome

• Risk Factors, Signs or Symptoms

• Increased LDH, uric acid, creatinine
• Bulky, rapidly proliferating tumors treated with chemotherapy
• Most often occurs with treatment of leukemias or high grade lymphomas
• Cardiac arrythmias if hyperkalemia or hypocalcemia
• Tetany if hypocalcemia
• Renal failure if hyperphosphatemia and hyperuricemia