Do not use aminogycosides or furosemide in a patient who recently received cisplatin unless there is no alternative.
Pancreatitis:
Asparaginase, Methotrexate
Peripheral neuropathy:
Vincristine, cis-Platin, Vinblastine, Etoposide (VP16), Taxanes
Pulmonary fibrosis:
Bleomycin, Cyclophosphamide (high dose), Bulsulfan, CCNU, BCNU
Renal tubular damage:
Cis-Platin (especially wasting of magnesium, potassium, calcium), Ifosfamide (especially wasting of bicarb, phosphorus, potassium, glucose [Fanconi’s syndrome])
Seizures:
Vincristine, Ifosfamide, intrathecal (IT) or high dose IV Methotrexate, IT Ara-C
Seizures after IT MTX can occur up to several weeks later, and is probably related to folate depletion, increased homocysteine and increased excitatory neurotransmitters. IV leucovorin can reverse the folate deficiency and po dextromethorphan can decrease the neurotransmitters.
SIADH (transient):
Vincristine, Cyclophosphamide, Ifosfamide
Tissue necrosis with extravasation:
Vincristine, Adriamycin, Daunomycin, Actinomycin
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