Oncology handbook


Do not use aminogycosides or furosemide in a patient who recently received cisplatin unless there is no alternative



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Do not use aminogycosides or furosemide in a patient who recently received cisplatin unless there is no alternative.
Pancreatitis:

Asparaginase, Methotrexate


Peripheral neuropathy:

Vincristine, cis-Platin, Vinblastine, Etoposide (VP16), Taxanes


Pulmonary fibrosis:

Bleomycin, Cyclophosphamide (high dose), Bulsulfan, CCNU, BCNU


Renal tubular damage:

Cis-Platin (especially wasting of magnesium, potassium, calcium), Ifosfamide (especially wasting of bicarb, phosphorus, potassium, glucose [Fanconi’s syndrome])


Seizures:

Vincristine, Ifosfamide, intrathecal (IT) or high dose IV Methotrexate, IT Ara-C


Seizures after IT MTX can occur up to several weeks later, and is probably related to folate depletion, increased homocysteine and increased excitatory neurotransmitters. IV leucovorin can reverse the folate deficiency and po dextromethorphan can decrease the neurotransmitters.
SIADH (transient):

Vincristine, Cyclophosphamide, Ifosfamide


Tissue necrosis with extravasation:

Vincristine, Adriamycin, Daunomycin, Actinomycin




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