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Poster presentation 
269 
DIRECTION OF ALKYLATION REACTIONS OF
2-METHYL-5-CHLOROBENZIMIDAZOLE 
 
B. B. Juraev, I. S. Ortikov, B. J. Elmuradov
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
Nowadays, benzimidazole derivatives play important role in medicine. They have 
many pharmacological activities such as antimicrobial, antiviral, antidiabetic and 
anticancer activity [1]. Benzimidazoles are remarkably effective compounds, extensive 
biochemical and pharmacological studies have confirmed that these molecules are 
effective against various strains of microorganisms [2]. Some of the synthesized 
compounds, for example 
Benomyl, Rabeprazol, Telmisartan
are used as fungicide, anti-
ulcer and anti-hypertensive agents [3]. 
In the present work we continued alkylation of 2-methyl-5-chlorobenzimidazole (
1
). 
To do that we carried out interaction of 2-methyl-5-chlorobenzimidazole (
1
) with 
n
-
amylchloride and 
i
-amylbromide:
Reactions carried out at boiling temperature of ethanol in the presence of NaOH for 
7-10 hours. As results, we have synthesized N-alkyl-5-chloro-2-methyl-derivatives 
(
2
a,b; 
3
a,b).
The structure of the obtained isomeric dialkyl products was confirmed by 
1
H and 
13
C 
NMR spectroscopy methods. 
 
References 
1. C.W. Evans, C. Atkins, A. Pathak, B.E. Gilbert, J.W. Noah, 
Antivir. Res
. 121 
(2015) 31-38.
2.
A.J.M. Horvat, M. Petrovic, S. Babic, D.M. Pavlovic, D. Asperger, S. Pelko, A.D. 
Mance, M.K. Macan, 
Trends. Anal. Chem.
31 (2012) 61-84. 
3.
R.H.B. Chunduri, G.S. Dannana, 
J. Pharm. Anal.
6 (2016) 190-198.

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Poster presentation 
270