Organizing co mmittee

2-4
). 
References 
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13-17. 

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Poster presentation 
271 
SYNTHESIS DERIVATIVES OF 5-FLUOROURACIL 
 
Sh.E. Ochilov
1
, G.S. Shakirzyanova 
2
, R.S. Esanov 
2
, A.D. Matchanov 
2 
 
1) The National University of Uzbekistan named after Mirzo Ulugbek, Ташкент, 4, 
University street, Tashkent, 100174, Uzbekistan 
2) Institute of Bioorganic Chemistry named after acad.A.S. Sadykov of the Academy of 
Sciences of the Republic of Uzbekistan 83, M.Ulugbek str.,Tashkent,100125, Uzbekistan 
Nowadays, a lot of new effective drugs for treating cancer is being increased. One of 
the well-known medicine is Fluorouracil (5-FU) - important clinically useful anticancer 
drug, were sold under the Adrucil. Fluorouracil is an effective antitumor agent, but at 
the same time, it has a strong toxicity and poor tumor affinity. Firstly, 5-Fluorouracil 
was synthesized in 1957. Combination chemotherapy including 5-FU has been used 
extensively in the treatment of a wide range of solid tumors, but its negative effects, 
such as mucositis, nausea, vomiting and cardiotoxicity have often been observed [1]. 
Specially for solving these problems, we tried to synthesis different derivatives of the 5-
FU, according to the method [2-3]: 
Scheme 
 
At the beginning of our experiment, 5-Fu was reacted with formaline (37% solution) 
till the mixture of 
N1
-hydroxymethylene-5-fluorouracil, 
N3
-hydroxymethylene-5-
fluorouracil and 
N
1
, N
3-dihydroxymethylene-5-fluorouracil (