Organizing co mmittee

SYNTHESIS OF NOVEL N
1
-ARYLSULFONYL-2-ETHYL-5-
METHYL-BENZIMIDAZOLES 
 
K. Abdireymov, B.J. Elmuradov
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of 
Sciences Republic of Uzbekistan, 100170, Tashkent, M. Ulugbek st., 77 
In the last decades, the broad research in the application of benzimidazole derivatives 
made it important for mankind. Many scientists have worked on benzimidazole 
derivatives and they found that this compound has a diverse role in the field of 
medicinal chemistry. Some benzimidazole derivatives are currently in the market as a 
drug candidate against various diseases. Moreover, the benzimidazole derivatives 
exhibit pharmacological activities such as anti-tuberculosis, anti-malarial, antihistamine, 
antimicrobial, antiviral, antidiabetic, anticancer, anti-fungal, anti-inflammatory, 
analgesic, anti-HIV, etc. [1-3]. 
Therefore, currying out targeted research on the synthesis and study of the biological 
activity of arylsulfonyl-benzimidazoles is very interest. 
In present work is described results of reactions of 2-ethyl-5-methylbenzimidazole 
(
1
) with substituted arylsulfonyl chlorides. The aim of this work was synthesis of 
potentially biological active arylsulfonyl derivatives of benzimidazoles (
2-8
): 
Arylsulfonylation of 2-ethyl-5-methylbenzimidazole (
1
) with substituted arylsulfonyl 
chlorides curried out in the presence of triethylamine at room temperature for 4 hours. 
As results we have synthesized corresponding N
1
-arylsulfonyl-2-ethyl-5-methyl-
benzimidazoles (
2-8
) in good yields. Structure of the synthesized compounds (
2-8
) was 
confirmed by results of
1
H, 
13
C NMR spectroscopy.